Kidney Failure Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood. (Human Disease Ontology, DOID_1074)
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Genes

47 genes associated with the Kidney Failure phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACE angiotensin I converting enzyme
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADD1 adducin 1 (alpha)
ADM adrenomedullin
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
APOE apolipoprotein E
CAMK1D calcium/calmodulin-dependent protein kinase ID
CCL2 chemokine (C-C motif) ligand 2
CDC123 cell division cycle 123
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHGA chromogranin A
CLCN5 chloride channel, voltage-sensitive 5
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
FTO fat mass and obesity associated
GHRL ghrelin/obestatin prepropeptide
HFE hemochromatosis
HHEX hematopoietically expressed homeobox
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFNG interferon, gamma
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL10 interleukin 10
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL6 interleukin 6
JAZF1 JAZF zinc finger 1
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NOTCH2 notch 2
SDC2 syndecan 2
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLCO1B3 solute carrier organic anion transporter family, member 1B3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
THADA thyroid adenoma associated
TNF tumor necrosis factor
TSPAN8 tetraspanin 8
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WFS1 Wolfram syndrome 1 (wolframin)