KRAS.LUNG_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/KRAS.LUNG_UP.V1_UP
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Genes

281 genes differentially expressed following the KRAS.LUNG_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADAM8 ADAM metallopeptidase domain 8
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALLC allantoicase
ANGPTL4 angiopoietin-like 4
ANO1 anoctamin 1, calcium activated chloride channel
ASGR2 asialoglycoprotein receptor 2
ATG10 autophagy related 10
AURKC aurora kinase C
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2A1 BCL2-related protein A1
BTC betacellulin
C17ORF53 chromosome 17 open reading frame 53
C3AR1 complement component 3a receptor 1
CCL20 chemokine (C-C motif) ligand 20
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2
CD1A CD1a molecule
CD247 CD247 molecule
CD48 CD48 molecule
CD80 CD80 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CELA2B chymotrypsin-like elastase family, member 2B
CFAP69 cilia and flagella associated protein 69
CLEC4A C-type lectin domain family 4, member A
CLSTN3 calsyntenin 3
CRYAA crystallin, alpha A
CSF3 colony stimulating factor 3 (granulocyte)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
CYTIP cytohesin 1 interacting protein
DCBLD2 discoidin, CUB and LCCL domain containing 2
DEFA5 defensin, alpha 5, Paneth cell-specific
DOCK2 dedicator of cytokinesis 2
DOCK4 dedicator of cytokinesis 4
EGFL7 EGF-like-domain, multiple 7
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EVI2A ecotropic viral integration site 2A
FABP3 fatty acid binding protein 3, muscle and heart
FBXO4 F-box protein 4
FNDC8 fibronectin type III domain containing 8
FRMD1 FERM domain containing 1
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
G0S2 G0/G1 switch 2
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
GPR3 G protein-coupled receptor 3
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIP2 glutamate receptor interacting protein 2
HBEGF heparin-binding EGF-like growth factor
HOXD11 homeobox D11
HPN hepsin
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFNA8 interferon, alpha 8
IGSF1 immunoglobulin superfamily, member 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13RA2 interleukin 13 receptor, alpha 2
IL1RL1 interleukin 1 receptor-like 1
IL23A interleukin 23, alpha subunit p19
INHBA inhibin, beta A
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JAK3 Janus kinase 3
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KIAA1549L KIAA1549-like
KIF5C kinesin family member 5C
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LAG3 lymphocyte-activation gene 3
LDB3 LIM domain binding 3
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LINC00472 long intergenic non-protein coding RNA 472
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAGEA6 melanoma antigen family A6
MMP1 matrix metallopeptidase 1
MMP20 matrix metallopeptidase 20
MT3 metallothionein 3
MYH2 myosin, heavy chain 2, skeletal muscle, adult
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAV3 neuron navigator 3
NDNF neuron-derived neurotrophic factor
NDOR1 NADPH dependent diflavin oxidoreductase 1
NELL2 NEL-like 2 (chicken)
NES nestin
NGF nerve growth factor (beta polypeptide)
NKX2-5 NK2 homeobox 5
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NRP1 neuropilin 1
NTM neurotrimin
OGDHL oxoglutarate dehydrogenase-like
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PAX4 paired box 4
PCDH17 protocadherin 17
PDCD1LG2 programmed cell death 1 ligand 2
POLM polymerase (DNA directed), mu
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRG3 proteoglycan 3
PRKG2 protein kinase, cGMP-dependent, type II
PTPRR protein tyrosine phosphatase, receptor type, R
RBP4 retinol binding protein 4, plasma
RELN reelin
RETN resistin
RGS4 regulator of G-protein signaling 4
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SARM1 sterile alpha and TIR motif containing 1
SCG5 secretogranin V
SDCCAG8 serologically defined colon cancer antigen 8
SEMG2 semenogelin II
SH2D2A SH2 domain containing 2A
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLCO5A1 solute carrier organic anion transporter family, member 5A1
SMPX small muscle protein, X-linked
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TAS2R1 taste receptor, type 2, member 1
TBX3 T-box 3
TEX13A testis expressed 13A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TNNT2 troponin T type 2 (cardiac)
TSPAN1 tetraspanin 1
TSPY1 testis specific protein, Y-linked 1
TTC22 tetratricopeptide repeat domain 22
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
WNT7A wingless-type MMTV integration site family, member 7A
ZBTB44 zinc finger and BTB domain containing 44
ZBTB48 zinc finger and BTB domain containing 48
ZNF639 zinc finger protein 639
ZNF749 zinc finger protein 749
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ACHE acetylcholinesterase (Yt blood group)
ACPP acid phosphatase, prostate
ADD2 adducin 2 (beta)
ADORA3 adenosine A3 receptor
AKAP4 A kinase (PRKA) anchor protein 4
AKAP6 A kinase (PRKA) anchor protein 6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
ATAT1 alpha tubulin acetyltransferase 1
BBC3 BCL2 binding component 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C11ORF80 chromosome 11 open reading frame 80
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CALML3 calmodulin-like 3
CALML5 calmodulin-like 5
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC132 coiled-coil domain containing 132
CCR2 chemokine (C-C motif) receptor 2
CD22 CD22 molecule
CD248 CD248 molecule, endosialin
CDH12 cadherin 12, type 2 (N-cadherin 2)
CDH16 cadherin 16, KSP-cadherin
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFAP74 cilia and flagella associated protein 74
CHRM5 cholinergic receptor, muscarinic 5
CLCA4 chloride channel accessory 4
COBL cordon-bleu WH2 repeat protein
COL19A1 collagen, type XIX, alpha 1
COL2A1 collagen, type II, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CXCL14 chemokine (C-X-C motif) ligand 14
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
EMID1 EMI domain containing 1
EPHB3 EPH receptor B3
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FMO2 flavin containing monooxygenase 2 (non-functional)
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8
GAS1 growth arrest-specific 1
GDNF glial cell derived neurotrophic factor
GLYAT glycine-N-acyltransferase
GPNMB glycoprotein (transmembrane) nmb
GPR45 G protein-coupled receptor 45
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IHH indian hedgehog
IL10RA interleukin 10 receptor, alpha
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IVL involucrin
KLK11 kallikrein-related peptidase 11
KLK12 kallikrein-related peptidase 12
KLK7 kallikrein-related peptidase 7
KLK8 kallikrein-related peptidase 8
KRT1 keratin 1, type II
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT4 keratin 4, type II
LGALS7 lectin, galactoside-binding, soluble, 7
LMO1 LIM domain only 1 (rhombotin 1)
LOC440895 two pore channel 3 pseudogene
LOC57399 uncharacterized gastric protein ZA52P
LY6D lymphocyte antigen 6 complex, locus D
LYPD3 LY6/PLAUR domain containing 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MC5R melanocortin 5 receptor
MEGF8 multiple EGF-like-domains 8
METTL7A methyltransferase like 7A
MORC1 MORC family CW-type zinc finger 1
MXRA8 matrix-remodelling associated 8
NGFR nerve growth factor receptor
NPY4R neuropeptide Y receptor Y4
NYNRIN NYN domain and retroviral integrase containing
OLFML2A olfactomedin-like 2A
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PALM paralemmin
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G10 phospholipase A2, group X
PLCH2 phospholipase C, eta 2
POSTN periostin, osteoblast specific factor
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PRODH proline dehydrogenase (oxidase) 1
PROM1 prominin 1
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTPRU protein tyrosine phosphatase, receptor type, U
RAB40AL RAB40A, member RAS oncogene family-like
RAG1 recombination activating gene 1
RDH16 retinol dehydrogenase 16 (all-trans)
RHCG Rh family, C glycoprotein
RTP4 receptor (chemosensory) transporter protein 4
RYR1 ryanodine receptor 1 (skeletal)
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
SAYSD1 SAYSVFN motif domain containing 1
SCARF1 scavenger receptor class F, member 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCN10A sodium channel, voltage gated, type X alpha subunit
SCRG1 stimulator of chondrogenesis 1
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH3BP1 SH3-domain binding protein 1
SH3GL3 SH3-domain GRB2-like 3
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SOX30 SRY (sex determining region Y)-box 30
SPRR3 small proline-rich protein 3
SPTBN2 spectrin, beta, non-erythrocytic 2
SRD5A3 steroid 5 alpha-reductase 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TF transferrin
TGM1 transglutaminase 1
THAP9 THAP domain containing 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRGV7 T cell receptor gamma variable 7 (pseudogene)
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIM48 tripartite motif containing 48
TSC22D4 TSC22 domain family, member 4
UPK3B uroplakin 3B
VAV3 vav 3 guanine nucleotide exchange factor
VPREB1 pre-B lymphocyte 1
WNT16 wingless-type MMTV integration site family, member 16
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF750 zinc finger protein 750
ZNF862 zinc finger protein 862