Ischemia Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A vascular disease that is characterized by a restriction in blood supply to tissues. (Human Disease Ontology, DOID_326)
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Genes

73 genes associated with the Ischemia phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACE angiotensin I converting enzyme
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMPD1 adenosine monophosphate deaminase 1
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CMA1 chymase 1, mast cell
CRP C-reactive protein, pentraxin-related
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
EDN1 endothelin 1
EPHX2 epoxide hydrolase 2, cytoplasmic
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FMO1 flavin containing monooxygenase 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FMO3 flavin containing monooxygenase 3
FMO4 flavin containing monooxygenase 4
GJA4 gap junction protein, alpha 4, 37kDa
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
ICAM1 intercellular adhesion molecule 1
IL10 interleukin 10
IL2 interleukin 2
IL21 interleukin 21
IL6 interleukin 6
KIF5A kinesin family member 5A
LPL lipoprotein lipase
LTC4S leukotriene C4 synthase
MBL2 mannose-binding lectin (protein C) 2, soluble
MMP3 matrix metallopeptidase 3
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NOS3 nitric oxide synthase 3 (endothelial cell)
OPRM1 opioid receptor, mu 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PDE4D phosphodiesterase 4D, cAMP-specific
PLAT plasminogen activator, tissue
PON1 paraoxonase 1
PRKCH protein kinase C, eta
PROZ protein Z, vitamin K-dependent plasma glycoprotein
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TCN2 transcobalamin II
TF transferrin
TNF tumor necrosis factor
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1