Intracranial Aneurysm Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

79 genes associated with the Intracranial Aneurysm phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACVR1 activin A receptor, type I
ACVRL1 activin A receptor type II-like 1
AGMO alkylglycerol monooxygenase
APOA1 apolipoprotein A-I
APOE apolipoprotein E
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
CBS cystathionine-beta-synthase
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2B-AS1 CDKN2B antisense RNA 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
DHFR dihydrofolate reductase
EDNRA endothelin receptor type A
ELN elastin
ENG endoglin
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
FBN2 fibrillin 2
FGF1 fibroblast growth factor 1 (acidic)
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GSTO1 glutathione S-transferase omega 1
HDAC9 histone deacetylase 9
HMOX1 heme oxygenase 1
HPN hepsin
HSPG2 heparan sulfate proteoglycan 2
IL12A interleukin 12A
IL12B interleukin 12B
IL6 interleukin 6
IQSEC1 IQ motif and Sec7 domain 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JDP2 Jun dimerization protein 2
KLK1 kallikrein 1
KLK4 kallikrein-related peptidase 4
KLK8 kallikrein-related peptidase 8
LIMK1 LIM domain kinase 1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LOXL2 lysyl oxidase-like 2
LOXL3 lysyl oxidase-like 3
LOXL4 lysyl oxidase-like 4
LPA lipoprotein, Lp(a)
LTBP4 latent transforming growth factor beta binding protein 4
MIR34B microRNA 34b
MIR34C microRNA 34c
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
PRDM6 PR domain containing 6
RFC1 replication factor C (activator 1) 1, 145kDa
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOX17 SRY (sex determining region Y)-box 17
STARD13 StAR-related lipid transfer (START) domain containing 13
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCN2 transcobalamin II
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TP53 tumor protein p53
VCAN versican
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase