IC-86621-7548 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the IC-86621-7548 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAP1 ArfGAP with dual PH domains 1
ADCY6 adenylate cyclase 6
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AKAP13 A kinase (PRKA) anchor protein 13
ANKRD26 ankyrin repeat domain 26
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAIAP3 BAI1-associated protein 3
C1ORF116 chromosome 1 open reading frame 116
C9ORF156 chromosome 9 open reading frame 156
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC68 coiled-coil domain containing 68
CCPG1 cell cycle progression 1
CDK12 cyclin-dependent kinase 12
CLDN8 claudin 8
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLU clusterin
COPE coatomer protein complex, subunit epsilon
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPNE7 copine VII
CROCC ciliary rootlet coiled-coil, rootletin
CRY2 cryptochrome circadian clock 2
CTH cystathionine gamma-lyase
CTNND2 catenin (cadherin-associated protein), delta 2
CTNS cystinosin, lysosomal cystine transporter
DVL2 dishevelled segment polarity protein 2
DXO decapping exoribonuclease
ELOVL2 ELOVL fatty acid elongase 2
EXD3 exonuclease 3'-5' domain containing 3
F11R F11 receptor
FBN2 fibrillin 2
FOXN3 forkhead box N3
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GLS2 glutaminase 2 (liver, mitochondrial)
GPR19 G protein-coupled receptor 19
HEMK1 HemK methyltransferase family member 1
HLX H2.0-like homeobox
HMHA1 histocompatibility (minor) HA-1
HN1L hematological and neurological expressed 1-like
HOXB5 homeobox B5
ICOSLG inducible T-cell co-stimulator ligand
INADL InaD-like (Drosophila)
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITPKA inositol-trisphosphate 3-kinase A
KDM6B lysine (K)-specific demethylase 6B
KLF12 Kruppel-like factor 12
LAMA4 laminin, alpha 4
LOC81691 exonuclease NEF-sp
LZTR1 leucine-zipper-like transcription regulator 1
MBD1 methyl-CpG binding domain protein 1
MCM9 minichromosome maintenance complex component 9
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MINK1 misshapen-like kinase 1
MTERF4 mitochondrial transcription termination factor 4
MUC3A mucin 3A, cell surface associated
MYH15 myosin, heavy chain 15
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP205 nucleoporin 205kDa
OGFR opioid growth factor receptor
OPTN optineurin
PHC3 polyhomeotic homolog 3 (Drosophila)
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLD1 phospholipase D1, phosphatidylcholine-specific
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB28 RAB28, member RAS oncogene family
RABGAP1 RAB GTPase activating protein 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
SAMD9 sterile alpha motif domain containing 9
SCG5 secretogranin V
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNX13 sorting nexin 13
STK24 serine/threonine kinase 24
STK4 serine/threonine kinase 4
STX2 syntaxin 2
SUGCT succinyl-CoA:glutarate-CoA transferase
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TAOK2 TAO kinase 2
TBCD tubulin folding cofactor D
TK2 thymidine kinase 2, mitochondrial
TMEM53 transmembrane protein 53
TRIM3 tripartite motif containing 3
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
USP22 ubiquitin specific peptidase 22
ZBTB39 zinc finger and BTB domain containing 39
ZBTB7A zinc finger and BTB domain containing 7A
ZNF253 zinc finger protein 253
ZNF358 zinc finger protein 358
ZNF671 zinc finger protein 671
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACADSB acyl-CoA dehydrogenase, short/branched chain
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARID5A AT rich interactive domain 5A (MRF1-like)
BMP4 bone morphogenetic protein 4
BNC1 basonuclin 1
BTBD18 BTB (POZ) domain containing 18
C1ORF27 chromosome 1 open reading frame 27
C20ORF195 chromosome 20 open reading frame 195
C7ORF43 chromosome 7 open reading frame 43
C9ORF40 chromosome 9 open reading frame 40
CARD9 caspase recruitment domain family, member 9
CCL22 chemokine (C-C motif) ligand 22
CDK18 cyclin-dependent kinase 18
CGREF1 cell growth regulator with EF-hand domain 1
CHM choroideremia (Rab escort protein 1)
CLCA1 chloride channel accessory 1
CLDN1 claudin 1
CLEC3B C-type lectin domain family 3, member B
CLTCL1 clathrin, heavy chain-like 1
COBL cordon-bleu WH2 repeat protein
CORO1A coronin, actin binding protein, 1A
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDN dendrin
EML4 echinoderm microtubule associated protein like 4
EPHX2 epoxide hydrolase 2, cytoplasmic
EPS8L3 EPS8-like 3
F3 coagulation factor III (thromboplastin, tissue factor)
FAM188A family with sequence similarity 188, member A
FILIP1L filamin A interacting protein 1-like
FMO4 flavin containing monooxygenase 4
GAS2 growth arrest-specific 2
GAS8 growth arrest-specific 8
GPR3 G protein-coupled receptor 3
GPR6 G protein-coupled receptor 6
HIST1H2AJ histone cluster 1, H2aj
HIST1H3I histone cluster 1, H3i
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IFI44L interferon-induced protein 44-like
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNA14 interferon, alpha 14
IL12RB2 interleukin 12 receptor, beta 2
INF2 inverted formin, FH2 and WH2 domain containing
IREB2 iron-responsive element binding protein 2
ITGA8 integrin, alpha 8
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LINC00115 long intergenic non-protein coding RNA 115
LMO7 LIM domain 7
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
MATN3 matrilin 3
METTL16 methyltransferase like 16
MICALL2 MICAL-like 2
MNX1 motor neuron and pancreas homeobox 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEK11 NIMA-related kinase 11
NID2 nidogen 2 (osteonidogen)
NPFFR1 neuropeptide FF receptor 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDE12 phosphodiesterase 12
PID1 phosphotyrosine interaction domain containing 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POU5F1B POU class 5 homeobox 1B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1-IT1 RUNX1 intronic transcript 1
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SDC3 syndecan 3
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SERTAD3 SERTA domain containing 3
SETD8 SET domain containing (lysine methyltransferase) 8
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SREK1IP1 SREK1-interacting protein 1
SULT4A1 sulfotransferase family 4A, member 1
SYCP2 synaptonemal complex protein 2
TENM1 teneurin transmembrane protein 1
TICAM1 toll-like receptor adaptor molecule 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM25 tripartite motif containing 25
UGT8 UDP glycosyltransferase 8
WASF1 WAS protein family, member 1
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZMAT5 zinc finger, matrin-type 5
ZNF197 zinc finger protein 197
ZNF219 zinc finger protein 219
ZNF442 zinc finger protein 442
ZNF552 zinc finger protein 552
ZNF74 zinc finger protein 74
ZNF816 zinc finger protein 816