IC-86621-7543 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the IC-86621-7543 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADRBK1 adrenergic, beta, receptor kinase 1
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ATG3 autophagy related 3
BBS7 Bardet-Biedl syndrome 7
C14ORF79 chromosome 14 open reading frame 79
C19ORF73 chromosome 19 open reading frame 73
C2ORF54 chromosome 2 open reading frame 54
C3 complement component 3
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDH18 cadherin 18, type 2
CDK3 cyclin-dependent kinase 3
CNOT4 CCR4-NOT transcription complex, subunit 4
CSHL1 chorionic somatomammotropin hormone-like 1
CUL7 cullin 7
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DMC1 DNA meiotic recombinase 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DZIP3 DAZ interacting zinc finger protein 3
EMC1 ER membrane protein complex subunit 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FAM134B family with sequence similarity 134, member B
FBXO11 F-box protein 11
FRK fyn-related Src family tyrosine kinase
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNS glucosamine (N-acetyl)-6-sulfatase
GPR153 G protein-coupled receptor 153
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GSTM1 glutathione S-transferase mu 1
HCAR3 hydroxycarboxylic acid receptor 3
HN1L hematological and neurological expressed 1-like
HP1BP3 heterochromatin protein 1, binding protein 3
IFITM1 interferon induced transmembrane protein 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ISG20 interferon stimulated exonuclease gene 20kDa
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF5C kinesin family member 5C
KLF3 Kruppel-like factor 3 (basic)
KLHL28 kelch-like family member 28
KRIT1 KRIT1, ankyrin repeat containing
KRT17 keratin 17, type I
LMF1 lipase maturation factor 1
LMO4 LIM domain only 4
LOC730101 uncharacterized LOC730101
LPXN leupaxin
LRP12 low density lipoprotein receptor-related protein 12
LRP5L low density lipoprotein receptor-related protein 5-like
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MCM3AP minichromosome maintenance complex component 3 associated protein
METTL3 methyltransferase like 3
MFAP2 microfibrillar-associated protein 2
MFAP3L microfibrillar-associated protein 3-like
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO1F myosin IF
PASK PAS domain containing serine/threonine kinase
PGK1 phosphoglycerate kinase 1
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PKP3 plakophilin 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPT2 palmitoyl-protein thioesterase 2
PSG1 pregnancy specific beta-1-glycoprotein 1
PTBP3 polypyrimidine tract binding protein 3
PTK6 protein tyrosine kinase 6
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RARG retinoic acid receptor, gamma
RBL2 retinoblastoma-like 2
RBM19 RNA binding motif protein 19
RIBC2 RIB43A domain with coiled-coils 2
RIPK2 receptor-interacting serine-threonine kinase 2
RPS14 ribosomal protein S14
RUFY3 RUN and FYVE domain containing 3
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SIX1 SIX homeobox 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
SMG6 SMG6 nonsense mediated mRNA decay factor
SPATA5L1 spermatogenesis associated 5-like 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STARD13 StAR-related lipid transfer (START) domain containing 13
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SZT2 seizure threshold 2 homolog (mouse)
TM2D1 TM2 domain containing 1
TMC7 transmembrane channel-like 7
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UBB ubiquitin B
ZFX zinc finger protein, X-linked
ZNF45 zinc finger protein 45
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACVR2B activin A receptor, type IIB
ADAP2 ArfGAP with dual PH domains 2
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAX BCL2-associated X protein
CALML5 calmodulin-like 5
CAMK1 calcium/calmodulin-dependent protein kinase I
CHRM3 cholinergic receptor, muscarinic 3
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLSPN claspin
CLSTN2 calsyntenin 2
CNGB3 cyclic nucleotide gated channel beta 3
CNTD2 cyclin N-terminal domain containing 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DBF4B DBF4 zinc finger B
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DTWD1 DTW domain containing 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ELP6 elongator acetyltransferase complex subunit 6
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV7 ets variant 7
FAM86C1 family with sequence similarity 86, member C1
FBXL2 F-box and leucine-rich repeat protein 2
FKRP fukutin related protein
FOXN2 forkhead box N2
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR182 G protein-coupled receptor 182
HDAC11 histone deacetylase 11
HIST1H1D histone cluster 1, H1d
HIST1H4C histone cluster 1, H4c
HSPA1L heat shock 70kDa protein 1-like
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IFI6 interferon, alpha-inducible protein 6
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCTD20 potassium channel tetramerization domain containing 20
KDM8 lysine (K)-specific demethylase 8
KIF16B kinesin family member 16B
KLHL25 kelch-like family member 25
KLK5 kallikrein-related peptidase 5
KRI1 KRI1 homolog (S. cerevisiae)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFGE8 milk fat globule-EGF factor 8 protein
MITF microphthalmia-associated transcription factor
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NKRF NFKB repressing factor
NME5 NME/NM23 family member 5
OTUD3 OTU deubiquitinase 3
PADI1 peptidyl arginine deiminase, type I
PARG poly (ADP-ribose) glycohydrolase
PAX9 paired box 9
PCBP4 poly(rC) binding protein 4
PCOLCE2 procollagen C-endopeptidase enhancer 2
PLAC1 placenta-specific 1
PLCD1 phospholipase C, delta 1
PLXNB3 plexin B3
PORCN porcupine homolog (Drosophila)
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PTTG3P pituitary tumor-transforming 3, pseudogene
RASAL1 RAS protein activator like 1 (GAP1 like)
RHOBTB2 Rho-related BTB domain containing 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF208 ring finger protein 208
RNF43 ring finger protein 43
RPAP1 RNA polymerase II associated protein 1
SCARA3 scavenger receptor class A, member 3
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC46A3 solute carrier family 46, member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SNIP1 Smad nuclear interacting protein 1
SPARCL1 SPARC-like 1 (hevin)
SPINK4 serine peptidase inhibitor, Kazal type 4
STIM1 stromal interaction molecule 1
SYCP2 synaptonemal complex protein 2
TAOK1 TAO kinase 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFBR3 transforming growth factor, beta receptor III
TIGD6 tigger transposable element derived 6
TMEM183A transmembrane protein 183A
TMEM53 transmembrane protein 53
TNNI3 troponin I type 3 (cardiac)
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTC30A tetratricopeptide repeat domain 30A
TUBA3C tubulin, alpha 3c
UBXN6 UBX domain protein 6
ULBP2 UL16 binding protein 2
VGF VGF nerve growth factor inducible
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB22 zinc finger and BTB domain containing 22
ZNF350 zinc finger protein 350
ZNF358 zinc finger protein 358
ZNF362 zinc finger protein 362