IBTK Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description inhibitor of Bruton agammaglobulinemia tyrosine kinase|Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] (NCBI Entrez Gene Database, 25998)
External Link http://www.ncbi.nlm.nih.gov/gene/25998
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26 interacting proteins for IBTK from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CD2BP2 CD2 (cytoplasmic tail) binding protein 2
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CUL3 cullin 3
EIF4A2 eukaryotic translation initiation factor 4A2
IGSF8 immunoglobulin superfamily, member 8
ITK IL2-inducible T-cell kinase
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LYN LYN proto-oncogene, Src family tyrosine kinase
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKD1 protein kinase D1
RGS2 regulator of G-protein signaling 2
SNRPN small nuclear ribonucleoprotein polypeptide N
SYK spleen tyrosine kinase
UBC ubiquitin C