Hypertrophy, Left Ventricular Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

137 genes associated with the Hypertrophy, Left Ventricular phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACTC1 actin, alpha, cardiac muscle 1
ADCY6 adenylate cyclase 6
ADD1 adducin 1 (alpha)
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
ALOX15 arachidonate 15-lipoxygenase
ANG angiogenin, ribonuclease, RNase A family, 5
APOB apolipoprotein B
APOE apolipoprotein E
AR androgen receptor
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATR ATR serine/threonine kinase
BDKRB2 bradykinin receptor B2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CMA1 chymase 1, mast cell
CMYA5 cardiomyopathy associated 5
CNBD1 cyclic nucleotide binding domain containing 1
CNTLN centlein, centrosomal protein
CPE carboxypeptidase E
CPT1A carnitine palmitoyltransferase 1A (liver)
CPT1B carnitine palmitoyltransferase 1B (muscle)
CPT2 carnitine palmitoyltransferase 2
CRNKL1 crooked neck pre-mRNA splicing factor 1
CRP C-reactive protein, pentraxin-related
CTF1 cardiotrophin 1
CTGF connective tissue growth factor
CYBA cytochrome b-245, alpha polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
EDN1 endothelin 1
EDNRA endothelin receptor type A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
GC group-specific component (vitamin D binding protein)
GDF15 growth differentiation factor 15
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GLA galactosidase, alpha
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GRK4 G protein-coupled receptor kinase 4
HFE hemochromatosis
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL15 interleukin 15
IL6 interleukin 6
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KIRREL3-AS3 KIRREL3 antisense RNA 3
KLK1 kallikrein 1
LAMP2 lysosomal-associated membrane protein 2
LEPR leptin receptor
LPL lipoprotein lipase
MEF2A myocyte enhancer factor 2A
MIR22 microRNA 22
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MSTN myostatin
MT-TL1 tRNA
MT-TT tRNA
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYBPC3 myosin binding protein C, cardiac
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYOCD myocardin
NCAM1 neural cell adhesion molecule 1
ND1
NMB neuromedin B
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPR1 natriuretic peptide receptor 1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY5R neuropeptide Y receptor Y5
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
POLG polymerase (DNA directed), gamma
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RYR1 ryanodine receptor 1 (skeletal)
SCN5A sodium channel, voltage gated, type V alpha subunit
SCN7A sodium channel, voltage gated, type VII alpha subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP2 secreted frizzled-related protein 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A46 solute carrier family 25, member 46
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOX5 SRY (sex determining region Y)-box 5
SPP1 secreted phosphoprotein 1
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
TH tyrosine hydroxylase
TIMP2 TIMP metallopeptidase inhibitor 2
TLCD2 TLC domain containing 2
TLR4 toll-like receptor 4
TMEM232 transmembrane protein 232
TMTC1 transmembrane and tetratricopeptide repeat containing 1
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TPM1 tropomyosin 1 (alpha)
TTN titin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B