Hypersensitivity Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods. (Human Disease Ontology, DOID_1205)
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Genes

200 genes associated with the Hypersensitivity phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACP1 acid phosphatase 1, soluble
ADA adenosine deaminase
ADAD1 adenosine deaminase domain containing 1 (testis-specific)
ADAM33 ADAM metallopeptidase domain 33
ADAM8 ADAM metallopeptidase domain 8
ADCY2 adenylate cyclase 2 (brain)
ADGRA1 adhesion G protein-coupled receptor A1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARG1 arginase 1
ARG2 arginase 2
BCAP29 B-cell receptor-associated protein 29
BDNF brain-derived neurotrophic factor
C11ORF30 chromosome 11 open reading frame 30
C3 complement component 3
C5AR1 complement component 5a receptor 1
CCDC26 CCDC26 long non-coding RNA
CCL2 chemokine (C-C motif) ligand 2
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD86 CD86 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2B-AS1 CDKN2B antisense RNA 1
CES2 carboxylesterase 2
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHIT1 chitinase 1 (chitotriosidase)
CLEC2D C-type lectin domain family 2, member D
CMA1 chymase 1, mast cell
COL6A5 collagen, type VI, alpha 5
COLEC11 collectin sub-family member 11
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYSLTR1 cysteinyl leukotriene receptor 1
DNAH5 dynein, axonemal, heavy chain 5
DOCK1 dedicator of cytokinesis 1
DPP10 dipeptidyl-peptidase 10 (non-functional)
EGFR epidermal growth factor receptor
EZR ezrin
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FANK1 fibronectin type III and ankyrin repeat domains 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGF1 fibroblast growth factor 1 (acidic)
FLG filaggrin
FNDC3A fibronectin type III domain containing 3A
FOXA1 forkhead box A1
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GSDMB gasdermin B
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HCP5 HLA complex P5 (non-protein coding)
HDC histidine decarboxylase
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNL3 interferon, lambda 3
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12B interleukin 12B
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL16 interleukin 16
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1B interleukin 1, beta
IL1RL1 interleukin 1 receptor-like 1
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
IL3 interleukin 3
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL9 interleukin 9
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KIF3A kinesin family member 3A
LPA lipoprotein, Lp(a)
LPP LIM domain containing preferred translocation partner in lipoma
LTA lymphotoxin alpha
LTA4H leukotriene A4 hydrolase
LTC4S leukotriene C4 synthase
LY96 lymphocyte antigen 96
MBL2 mannose-binding lectin (protein C) 2, soluble
MCM6 minichromosome maintenance complex component 6
MICA MHC class I polypeptide-related sequence A
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MRPL4 mitochondrial ribosomal protein L4
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX3 NADPH oxidase 3
NPSR1 neuropeptide S receptor 1
NPSR1-AS1 NPSR1 antisense RNA 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
PDE11A phosphodiesterase 11A
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE4B phosphodiesterase 4B, cAMP-specific
PGAP3 post-GPI attachment to proteins 3
PHF11 PHD finger protein 11
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLAU plasminogen activator, urokinase
PLCL1 phospholipase C-like 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRE protein tyrosine phosphatase, receptor type, E
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RORA RAR-related orphan receptor A
RTEL1 regulator of telomere elongation helicase 1
RTEL1-TNFRSF6B RTEL1-TNFRSF6B readthrough (NMD candidate)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB3A2 secretoglobin, family 3A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SETDB2 SET domain, bifurcated 2
SLC25A46 solute carrier family 25, member 46
SMAD3 SMAD family member 3
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNX9 sorting nexin 9
SOCS1 suppressor of cytokine signaling 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPP1 secreted phosphoprotein 1
SPRR2B small proline-rich protein 2B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBX21 T-box 21
TBXA2R thromboxane A2 receptor
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TIMELESS timeless circadian clock
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR9 toll-like receptor 9
TNC tenascin C
TNF tumor necrosis factor
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TTC6 tetratricopeptide repeat domain 6
VIP vasoactive intestinal peptide