Hyperplasia Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormal increase in the number of cells in an organ or a tissue with consequent enlargement.|An abnormal increase in the number of (otherwise normal) cells in an organ or a tissue with consequent enlargement. (Experimental Factor Ontology, EFO_0000536)
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Genes

52 genes associated with the Hyperplasia phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACVRL1 activin A receptor type II-like 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APC adenomatous polyposis coli
AR androgen receptor
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CASC1 cancer susceptibility candidate 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
DIRAS3 DIRAS family, GTP-binding RAS-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC2 excision repair cross-complementation group 2
ERCC5 excision repair cross-complementation group 5
ESR1 estrogen receptor 1
GH1 growth hormone 1
HDAC3 histone deacetylase 3
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
JAK2 Janus kinase 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
LEP leptin
LRMP lymphoid-restricted membrane protein
MGMT O-6-methylguanine-DNA methyltransferase
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NOD2 nucleotide-binding oligomerization domain containing 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PTEN phosphatase and tensin homolog
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RET ret proto-oncogene
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
STK11 serine/threonine kinase 11
TGFB1 transforming growth factor, beta 1
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TYMS thymidylate synthetase