Hyperlipidemias Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

163 genes associated with the Hyperlipidemias phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
3.8-1.2 HLA complex group 26 (non-protein coding) pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
ACAT1 acetyl-CoA acetyltransferase 1
ACAT2 acetyl-CoA acetyltransferase 2
ACE angiotensin I converting enzyme
ACP1 acid phosphatase 1, soluble
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
ALOX5 arachidonate 5-lipoxygenase
AMPD1 adenosine monophosphate deaminase 1
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APTX aprataxin
AQP4 aquaporin 4
AS3MT arsenite methyltransferase
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CAV3 caveolin 3
CDC73 cell division cycle 73
CDCP1 CUB domain containing protein 1
CDH13 cadherin 13
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEL carboxyl ester lipase
CETP cholesteryl ester transfer protein, plasma
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CPT1A carnitine palmitoyltransferase 1A (liver)
CPT1B carnitine palmitoyltransferase 1B (muscle)
CPT2 carnitine palmitoyltransferase 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP3A51P cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DENND1A DENN/MADD domain containing 1A
DISC1 disrupted in schizophrenia 1
DMD dystrophin
DMPK dystrophia myotonica-protein kinase
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FABP2 fatty acid binding protein 2, intestinal
FAS Fas cell surface death receptor
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXC2 forkhead box C2
GAA glucosidase, alpha; acid
GAL galanin/GMAP prepropeptide
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNF4A hepatocyte nuclear factor 4, alpha
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IL10 interleukin 10
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCTD10 potassium channel tetramerization domain containing 10
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LEPR leptin receptor
LHCGR luteinizing hormone/choriogonadotropin receptor
LIPC lipase, hepatic
LMNA lamin A/C
LPL lipoprotein lipase
LRP2 low density lipoprotein receptor-related protein 2
LTA lymphotoxin alpha
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type
MMP3 matrix metallopeptidase 3
MTAP methylthioadenosine phosphorylase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTTP microsomal triglyceride transfer protein
MVK mevalonate kinase
MYLIP myosin regulatory light chain interacting protein
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1L1 NPC1-like 1
NPY neuropeptide Y
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OSBPL9 oxysterol binding protein-like 9
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PLAGL1 pleiomorphic adenoma gene-like 1
PLTP phospholipid transfer protein
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PRDM16 PR domain containing 16
PRSS1 protease, serine, 1 (trypsin 1)
PYGM phosphorylase, glycogen, muscle
RBP4 retinol binding protein 4, plasma
REN renin
RET ret proto-oncogene
RGS2 regulator of G-protein signaling 2
RMDN1 regulator of microtubule dynamics 1
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
SCAP SREBF chaperone
SCARB1 scavenger receptor class B, member 1
SDC1 syndecan 1
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SOAT1 sterol O-acyltransferase 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SULF2 sulfatase 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
THADA thyroid adenoma associated
TNF tumor necrosis factor
UBL5 ubiquitin-like 5
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNK4 WNK lysine deficient protein kinase 4