Hydroxyurea Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. (Chemical Entities of Biological Interest Ontology, CHEBI_44423)
External Link http://ctdbase.org/detail.go?type=chem&acc=D006918
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Genes

65 genes/proteins interacting with the chemical Hydroxyurea from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ALDOA aldolase A, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
ATR ATR serine/threonine kinase
BCL2L1 BCL2-like 1
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CDK4 cyclin-dependent kinase 4
CDK5RAP1 CDK5 regulatory subunit associated protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK1 checkpoint kinase 1
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CXCR1 chemokine (C-X-C motif) receptor 1
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DYM dymeclin
ECH1 enoyl CoA hydratase 1, peroxisomal
EDN3 endothelin 3
EPO erythropoietin
FANCD2 Fanconi anemia, complementation group D2
FOS FBJ murine osteosarcoma viral oncogene homolog
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GEN1 GEN1 Holliday junction 5' flap endonuclease
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GRB14 growth factor receptor-bound protein 14
HDAC2 histone deacetylase 2
HESX1 HESX homeobox 1
IL13 interleukin 13
KIF3B kinesin family member 3B
L1RE1 LINE1 retrotransposable element 1
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MAGEA1 melanoma antigen family A1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECOM MDS1 and EVI1 complex locus
MIPOL1 mirror-image polydactyly 1
PRUNE prune exopolyphosphatase
RARA retinoic acid receptor, alpha
RBM4 RNA binding motif protein 4
RFX4 regulatory factor X, 4 (influences HLA class II expression)
RRM2 ribonucleotide reductase M2
RUNX1 runt-related transcription factor 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC16A12 solute carrier family 16, member 12
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPINK4 serine peptidase inhibitor, Kazal type 4
TBPL1 TBP-like 1
TMEM69 transmembrane protein 69
TNF tumor necrosis factor
TP53 tumor protein p53
TPP2 tripeptidyl peptidase II
TRADD TNFRSF1A-associated via death domain
UBAC2 UBA domain containing 2
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)