Hip Fractures Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES). (Experimental Factor Ontology, EFO_0003964)
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Genes

52 genes associated with the Hip Fractures phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18
APOE apolipoprotein E
AR androgen receptor
C7ORF76 chromosome 7 open reading frame 76
CNR2 cannabinoid receptor 2 (macrophage)
COL1A1 collagen, type I, alpha 1
COMT catechol-O-methyltransferase
CUBN cubilin (intrinsic factor-cobalamin receptor)
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DCHS2 dachsous cadherin-related 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FRZB frizzled-related protein
GC group-specific component (vitamin D binding protein)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1A interleukin 1, alpha
IL6 interleukin 6
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KL klotho
LCT lactase
LRP2 low density lipoprotein receptor-related protein 2
LRP4 low density lipoprotein receptor-related protein 4
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NOS3 nitric oxide synthase 3 (endothelial cell)
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PPARG peroxisome proliferator-activated receptor gamma
PTH parathyroid hormone
RTP3 receptor (chemosensory) transporter protein 3
SFRP1 secreted frizzled-related protein 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOST sclerostin
SPTBN1 spectrin, beta, non-erythrocytic 1
TGFBR3 transforming growth factor, beta receptor III
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNT10A wingless-type MMTV integration site family, member 10A
WNT10B wingless-type MMTV integration site family, member 10B
WNT16 wingless-type MMTV integration site family, member 16
WNT4 wingless-type MMTV integration site family, member 4
ZBTB40 zinc finger and BTB domain containing 40