Hemorrhage Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels (Mammalian Phenotype Ontology, MP_0001914)
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Genes

65 genes associated with the Hemorrhage phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
APOE apolipoprotein E
CALU calumenin
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CES1 carboxylesterase 1
COL3A1 collagen, type III, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CRP C-reactive protein, pentraxin-related
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F12 coagulation factor XII (Hageman factor)
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
F9 coagulation factor IX
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
GGCX gamma-glutamyl carboxylase
GNAS GNAS complex locus
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP6 glycoprotein VI (platelet)
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK2 Janus kinase 2
LMAN1 lectin, mannose-binding, 1
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NQO1 NAD(P)H dehydrogenase, quinone 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOD1 superoxide dismutase 1, soluble
SOX17 SRY (sex determining region Y)-box 17
STARD13 StAR-related lipid transfer (START) domain containing 13
STX2 syntaxin 2
STXBP5 syntaxin binding protein 5 (tomosyn)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBD thrombomodulin
TNF tumor necrosis factor
VKORC1 vitamin K epoxide reductase complex, subunit 1
VWF von Willebrand factor
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3