Hemolytic-Uremic Syndrome Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Xref MGI. (Human Disease Ontology, DOID_12554)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D006463
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Genes

290 genes/proteins associated with the disease Hemolytic-Uremic Syndrome from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
IL1B interleukin 1, beta 2.88009
ALB albumin 2.88009
IL1A interleukin 1, alpha 2.88009
TNF tumor necrosis factor 2.88009
IL6 interleukin 6 2.88009
NQO1 NAD(P)H dehydrogenase, quinone 1 2.88009
EPO erythropoietin 2.88009
VCAM1 vascular cell adhesion molecule 1 2.02033
CXCL8 chemokine (C-X-C motif) ligand 8 2.00151
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.98697
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.95964
CCL2 chemokine (C-C motif) ligand 2 1.82586
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.79808
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.77511
MPO myeloperoxidase 1.76985
ICAM1 intercellular adhesion molecule 1 1.75738
VEGFA vascular endothelial growth factor A 1.7552
IL4 interleukin 4 1.74521
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.73414
TGFB1 transforming growth factor, beta 1 1.7107
BCL2 B-cell CLL/lymphoma 2 1.70119
BCL2L1 BCL2-like 1 1.69701
FASLG Fas ligand (TNF superfamily, member 6) 1.69597
F3 coagulation factor III (thromboplastin, tissue factor) 1.6947
MCL1 myeloid cell leukemia 1 1.69211
FOS FBJ murine osteosarcoma viral oncogene homolog 1.69146
BAX BCL2-associated X protein 1.68253
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.66555
NOS3 nitric oxide synthase 3 (endothelial cell) 1.66468
PARP1 poly (ADP-ribose) polymerase 1 1.66403
IFNG interferon, gamma 1.6381
THBS1 thrombospondin 1 1.63541
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.62199
FAS Fas cell surface death receptor 1.61967
CAT catalase 1.61851
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.61529
EDN1 endothelin 1 1.60688
DDIT3 DNA-damage-inducible transcript 3 1.59195
XBP1 X-box binding protein 1 1.59054
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.58514
ATF4 activating transcription factor 4 1.58232
EGFR epidermal growth factor receptor 1.57665
F2 coagulation factor II (thrombin) 1.55059
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.54669
TP53 tumor protein p53 1.54475
HMOX1 heme oxygenase 1 1.54402
CDK2 cyclin-dependent kinase 2 1.54208
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.53772
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.53357
NOS2 nitric oxide synthase 2, inducible 1.52914
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.52566
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.5181
MMP1 matrix metallopeptidase 1 1.51456
CTGF connective tissue growth factor 1.51456
CCND1 cyclin D1 1.50801
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.50498
SOD2 superoxide dismutase 2, mitochondrial 1.50273
BIRC5 baculoviral IAP repeat containing 5 1.48684
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.47889
MMP9 matrix metallopeptidase 9 1.47686
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.47219
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.46568
CP ceruloplasmin (ferroxidase) 1.44763
KLF6 Kruppel-like factor 6 1.43401
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.43347
EGR1 early growth response 1 1.42967
CD40LG CD40 ligand 1.42777
JUN jun proto-oncogene 1.42347
TYMP thymidine phosphorylase 1.42183
BDNF brain-derived neurotrophic factor 1.42101
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.41775
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.41505
HSPB8 heat shock 22kDa protein 8 1.41008
GSK3B glycogen synthase kinase 3 beta 1.39757
TOP2A topoisomerase (DNA) II alpha 170kDa 1.39646
BAD BCL2-associated agonist of cell death 1.39507
BIRC2 baculoviral IAP repeat containing 2 1.39451
CCNB2 cyclin B2 1.38527
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.37902
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.37817
TRIM2 tripartite motif containing 2 1.37532
GADD45A growth arrest and DNA-damage-inducible, alpha 1.37303
SELE selectin E 1.36905
MAPK8 mitogen-activated protein kinase 8 1.36591
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.35877
ERBB2 erb-b2 receptor tyrosine kinase 2 1.35877
CCNB1 cyclin B1 1.35676
BTG2 BTG family, member 2 1.35386
CXCL10 chemokine (C-X-C motif) ligand 10 1.35242
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.35041
BID BH3 interacting domain death agonist 1.34401
CD44 CD44 molecule (Indian blood group) 1.34401
CDC6 cell division cycle 6 1.34256
MAPK3 mitogen-activated protein kinase 3 1.34111
MMP3 matrix metallopeptidase 3 1.33909
FOSL1 FOS-like antigen 1 1.33583
AURKA aurora kinase A 1.3311
PRKCD protein kinase C, delta 1.32786
PLAU plasminogen activator, urokinase 1.32339
BIRC3 baculoviral IAP repeat containing 3 1.30512
CDK1 cyclin-dependent kinase 1 1.29966
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 1.29287
PPARA peroxisome proliferator-activated receptor alpha 1.29164
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.28027
MACF1 microtubule-actin crosslinking factor 1 1.27813
SPP1 secreted phosphoprotein 1 1.2772
GDF15 growth differentiation factor 15 1.27657
CYBA cytochrome b-245, alpha polypeptide 1.27471
SESN1 sestrin 1 1.2744
VWF von Willebrand factor 1.27162
PPARG peroxisome proliferator-activated receptor gamma 1.26856
FKBP1B FK506 binding protein 1B, 12.6 kDa 1.26825
CLU clusterin 1.26732
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.26144
CFLAR CASP8 and FADD-like apoptosis regulator 1.26144
SRXN1 sulfiredoxin 1 1.25807
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.25214
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.25059
FOSL2 FOS-like antigen 2 1.24966
DUSP1 dual specificity phosphatase 1 1.24935
FANCG Fanconi anemia, complementation group G 1.24496
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.24433
MAPK1 mitogen-activated protein kinase 1 1.24307
COL1A1 collagen, type I, alpha 1 1.24307
SAT1 spermidine/spermine N1-acetyltransferase 1 1.2415
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.2415
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.2393
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.2393
AREG amphiregulin 1.23868
NUPR1 nuclear protein, transcriptional regulator, 1 1.2368
RB1 retinoblastoma 1 1.23648
LCN2 lipocalin 2 1.22664
SP1 Sp1 transcription factor 1.22501
SOD1 superoxide dismutase 1, soluble 1.22404
EGF epidermal growth factor 1.22112
CCL3 chemokine (C-C motif) ligand 3 1.21984
CCNG2 cyclin G2 1.21887
C3 complement component 3 1.21855
GSTP1 glutathione S-transferase pi 1 1.21631
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.21631
S100A4 S100 calcium binding protein A4 1.21173
GCLM glutamate-cysteine ligase, modifier subunit 1.21173
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.20687
ATF3 activating transcription factor 3 1.20262
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.20262
MAPK14 mitogen-activated protein kinase 14 1.2013
IFRD1 interferon-related developmental regulator 1 1.1977
DPYD dihydropyrimidine dehydrogenase 1.19312
LMNA lamin A/C 1.19312
ACKR3 atypical chemokine receptor 3 1.19213
IGF1 insulin-like growth factor 1 (somatomedin C) 1.19047
SLC16A6 solute carrier family 16, member 6 1.18849
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.17993
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.17794
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.17333
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.17168
S100A9 S100 calcium binding protein A9 1.16335
PRNP prion protein 1.16335
CXCL2 chemokine (C-X-C motif) ligand 2 1.1607
MKI67 marker of proliferation Ki-67 1.16001
HBEGF heparin-binding EGF-like growth factor 1.15526
S100A11 S100 calcium binding protein A11 1.15458
PHLDA3 pleckstrin homology-like domain, family A, member 3 1.15122
PTEN phosphatase and tensin homolog 1.14919
PLAT plasminogen activator, tissue 1.14919
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.14919
IL5 interleukin 5 1.14919
MR1 major histocompatibility complex, class I-related 1.14781
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.14541
NPPA natriuretic peptide A 1.13963
TFRC transferrin receptor 1.13449
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.13381
TGFA transforming growth factor, alpha 1.13211
TERT telomerase reverse transcriptase 1.13041
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.12805
PRC1 protein regulator of cytokinesis 1 1.12737
KIF23 kinesin family member 23 1.12703
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.12495
FGF7 fibroblast growth factor 7 1.12426
LTA lymphotoxin alpha 1.12426
HMMR hyaluronan-mediated motility receptor (RHAMM) 1.11843
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 1.11571
PDIA4 protein disulfide isomerase family A, member 4 1.1129
HSPA1A heat shock 70kDa protein 1A 1.1122
IL1RN interleukin 1 receptor antagonist 1.11081
HSPA1B heat shock 70kDa protein 1B 1.10907
BRCA1 breast cancer 1, early onset 1.10907
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.10769
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 1.10769
IL10 interleukin 10 1.10631
MYOF myoferlin 1.10562
APP amyloid beta (A4) precursor protein 1.10493
PCNA proliferating cell nuclear antigen 1.10388
EIF4E eukaryotic translation initiation factor 4E 1.10246
MME membrane metallo-endopeptidase 1.10211
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 1.10069
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1.09963
GPNMB glycoprotein (transmembrane) nmb 1.09681
CDC25A cell division cycle 25A 1.09681
ESM1 endothelial cell-specific molecule 1 1.09611
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.09401
E2F1 E2F transcription factor 1 1.09226
CCNA2 cyclin A2 1.0919
INHBE inhibin, beta E 1.0894
CTSB cathepsin B 1.08868
MGMT O-6-methylguanine-DNA methyltransferase 1.08726
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.0869
IL2 interleukin 2 1.08655
CD274 CD274 molecule 1.08655
GJB1 gap junction protein, beta 1, 32kDa 1.08655
CSF1 colony stimulating factor 1 (macrophage) 1.08407
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 1.08407
NCF2 neutrophil cytosolic factor 2 1.08407
MARCKS myristoylated alanine-rich protein kinase C substrate 1.08407
PMP22 peripheral myelin protein 22 1.08407
NFE2L2 nuclear factor, erythroid 2-like 2 1.08301
TRIB2 tribbles pseudokinase 2 1.08196
BAG3 BCL2-associated athanogene 3 1.08161
PSAT1 phosphoserine aminotransferase 1 1.08161
TF transferrin 1.07911
FN1 fibronectin 1 1.07625
DDIT4 DNA-damage-inducible transcript 4 1.07589
HDAC4 histone deacetylase 4 1.0734
RANBP1 RAN binding protein 1 1.0734
TPI1 triosephosphate isomerase 1 1.07199
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.06952
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.06734
PLK1 polo-like kinase 1 1.06734
ABHD4 abhydrolase domain containing 4 1.06479
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.06479
MXI1 MAX interactor 1, dimerization protein 1.06479
DIABLO diablo, IAP-binding mitochondrial protein 1.06261
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.06225
CRIP2 cysteine-rich protein 2 1.0608
LIF leukemia inhibitory factor 1.05535
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.05461
G0S2 G0/G1 switch 2 1.05312
IL2RA interleukin 2 receptor, alpha 1.05312
BCAR3 breast cancer anti-estrogen resistance 3 1.05237
TYMS thymidylate synthetase 1.05163
NOS1 nitric oxide synthase 1 (neuronal) 1.05015
RNF113A ring finger protein 113A 1.04978
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 1.04868
RPS27L ribosomal protein S27-like 1.04868
MMP2 matrix metallopeptidase 2 1.04868
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.04647
TP53I3 tumor protein p53 inducible protein 3 1.04501
SPON1 spondin 1, extracellular matrix protein 1.04465
NRP1 neuropilin 1 1.04427
MCM2 minichromosome maintenance complex component 2 1.04427
UBE2C ubiquitin-conjugating enzyme E2C 1.04427
TP53INP1 tumor protein p53 inducible nuclear protein 1 1.04088
BLM Bloom syndrome, RecQ helicase-like 1.04088
MAGEA6 melanoma antigen family A6 1.03976
MAGEA12 melanoma antigen family A12 1.03976
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.03901
CCL11 chemokine (C-C motif) ligand 11 1.03789
LEP leptin 1.03789
BAMBI BMP and activin membrane-bound inhibitor 1.03715
EPOR erythropoietin receptor 1.03678
MBP myelin basic protein 1.03345
SSTR2 somatostatin receptor 2 1.03345
TIMP1 TIMP metallopeptidase inhibitor 1 1.03159
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.03122
F2R coagulation factor II (thrombin) receptor 1.03122
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.03122
GSTT1 glutathione S-transferase theta 1 1.03009
AQP1 aquaporin 1 (Colton blood group) 1.02896
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 1.02896
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 1.02596
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 1.02596
MAP2K1 mitogen-activated protein kinase kinase 1 1.02447
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.02336
BTG3 BTG family, member 3 1.02225
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.02077
FOXO3 forkhead box O3 1.02077
HSPA8 heat shock 70kDa protein 8 1.0204
TOB1 transducer of ERBB2, 1 1.01852
RND2 Rho family GTPase 2 1.01739
SYBU syntabulin (syntaxin-interacting) 1.01739
JUNB jun B proto-oncogene 1.01663
NINJ1 ninjurin 1 1.01512
CD36 CD36 molecule (thrombospondin receptor) 1.01512
NOX1 NADPH oxidase 1 1.01249
PON1 paraoxonase 1 1.01249
H2AFX H2A histone family, member X 1.01249
IL18 interleukin 18 1.01249
SDF2L1 stromal cell-derived factor 2-like 1 1.01212
SMIM14 small integral membrane protein 14 1.01137
MOK MOK protein kinase 1.01062