Hematologic Diseases Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

313 genes associated with the Hematologic Diseases phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD13 abhydrolase domain containing 13
ACOXL acyl-CoA oxidase-like
AICDA activation-induced cytidine deaminase
ALS2CR12 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12
ANKRD49 ankyrin repeat domain 49
ANO1 anoctamin 1, calcium activated chloride channel
BAX BCL2-associated X protein
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BCL7A B-cell CLL/lymphoma 7A
BCL7C B-cell CLL/lymphoma 7C
BIVM basic, immunoglobulin-like variable motif containing
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C11ORF74 chromosome 11 open reading frame 74
C16ORF70 chromosome 16 open reading frame 70
C19ORF68 chromosome 19 open reading frame 68
C1ORF52 chromosome 1 open reading frame 52
C3 complement component 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP1P2 caspase 1, apoptosis-related cysteine peptidase pseudogene 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCDC105 coiled-coil domain containing 105
CCDC109B coiled-coil domain containing 109B
CCND1 cyclin D1
CD27 CD27 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD3EAP CD3e molecule, epsilon associated protein
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD5 CD5 molecule
CD70 CD70 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CELA2B chymotrypsin-like elastase family, member 2B
CENPM centromere protein M
CFLAR CASP8 and FADD-like apoptosis regulator
CHMP7 charged multivesicular body protein 7
CHUK conserved helix-loop-helix ubiquitous kinase
CLASRP CLK4-associating serine/arginine rich protein
CLCN1 chloride channel, voltage-sensitive 1
CLDN6 claudin 6
CLDN9 claudin 9
CLPTM1 cleft lip and palate associated transmembrane protein 1
CSF3 colony stimulating factor 3 (granulocyte)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DAAM2 dishevelled associated activator of morphogenesis 2
DCK deoxycytidine kinase
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DHDH dihydrodiol dehydrogenase (dimeric)
DKK4 dickkopf WNT signaling pathway inhibitor 4
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DNAJC8P1 DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPYD dihydropyrimidine dehydrogenase
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ESPN espin
F5 coagulation factor V (proaccelerin, labile factor)
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGFR4 fibroblast growth factor receptor 4
FRY furry homolog (Drosophila)
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GH1 growth hormone 1
GJA10 gap junction protein, alpha 10, 62kDa
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPR162 G protein-coupled receptor 162
GPX1 glutathione peroxidase 1
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GYS1 glycogen synthase 1 (muscle)
HBA1 hemoglobin, alpha 1
HFE hemochromatosis
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMHA1 histocompatibility (minor) HA-1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ICAM5 intercellular adhesion molecule 5, telencephalin
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL15 interleukin 15
IL18 interleukin 18
IL19 interleukin 19
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RL2 interleukin 1 receptor-like 2
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL9 interleukin 9
INSL3 insulin-like 3 (Leydig cell)
IRF4 interferon regulatory factor 4
IRGQ immunity-related GTPase family, Q
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
JAK3 Janus kinase 3
KDSR 3-ketodihydrosphingosine reductase
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLC1 kinesin light chain 1
KMT2D lysine (K)-specific methyltransferase 2D
LAG3 lymphocyte-activation gene 3
LCT lactase
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LINC00467 long intergenic non-protein coding RNA 467
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC389641 uncharacterized LOC389641
LOC390998 ribosomal protein L10 pseudogene
LST1 leukocyte specific transcript 1
LTA lymphotoxin alpha
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MANBA mannosidase, beta A, lysosomal
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDN1 MDN1, midasin homolog (yeast)
METTL21EP methyltransferase like 21E, pseudogene
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIIP migration and invasion inhibitory protein
MPL MPL proto-oncogene, thrombopoietin receptor
MPO myeloperoxidase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MRPL4 mitochondrial ribosomal protein L4
MRPS33P1 mitochondrial ribosomal protein S33 pseudogene 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L1 NEDD4 binding protein 2-like 1
NBN nibrin
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NFRKB nuclear factor related to kappaB binding protein
NOD2 nucleotide-binding oligomerization domain containing 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NQO1 NAD(P)H dehydrogenase, quinone 1
P3H3 prolyl 3-hydroxylase 3
PABPN1 poly(A) binding protein, nuclear 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PFN4 profilin family, member 4
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G12A phospholipase A2, group XIIA
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP1R3E protein phosphatase 1, regulatory subunit 3E
PRDM10 PR domain containing 10
PRIMPOL primase and polymerase (DNA-directed)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSD pleckstrin and Sec7 domain containing
PTMS parathymosin
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PUS10 pseudouridylate synthase 10
RAB15 RAB15, member RAS oncogene family
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD54L RAD54-like (S. cerevisiae)
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RCOR3 REST corepressor 3
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFC1 replication factor C (activator 1) 1, 145kDa
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RHOA ras homolog family member A
RHOBTB2 Rho-related BTB domain containing 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RMDN3 regulator of microtubule dynamics 3
RNF175 ring finger protein 175
RPL13P2 ribosomal protein L13 pseudogene 2
RPS19 ribosomal protein S19
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDF4 stromal cell derived factor 4
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SERPINB8P1 serpin peptidase inhibitor, clade B8 (ovalbumin) pseudogene 1
SF3B6 splicing factor 3b, subunit 6, 14kDa
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIPA1 signal-induced proliferation-associated 1
SLC25A48 solute carrier family 25, member 48
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
SRP14P1 signal recognition particle 14kDa (homologous Alu RNA binding protein) pseudogene 1
TANK TRAF family member-associated NFKB activator
TAPBPL TAP binding protein-like
TBC1D27 TBC1 domain family, member 27
TCTE1 t-complex-associated-testis-expressed 1
TEX12 testis expressed 12
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
THOC6 THO complex 6
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TMEM139 transmembrane protein 139
TMEM151B transmembrane protein 151B
TMEM45B transmembrane protein 45B
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TP53I3 tumor protein p53 inducible protein 3
TPMT thiopurine S-methyltransferase
TPX2 TPX2, microtubule-associated
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPM5 transient receptor potential cation channel, subfamily M, member 5
TUBB4A tubulin, beta 4A class IVa
TYMS thymidylate synthetase
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
WDR66 WD repeat domain 66
WRN Werner syndrome, RecQ helicase-like
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZFYVE21 zinc finger, FYVE domain containing 21
ZNF575 zinc finger protein 575
ZNF830 zinc finger protein 830