Heart Rate Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description The number of times the HEART VENTRICLES contract per unit of time, usually per minute. (Experimental Factor Ontology, EFO_0004326)
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Genes

155 genes associated with the trait Heart Rate in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.15135
ELMO1 engulfment and cell motility 1 0.979311
SLC35F1 solute carrier family 35, member F1 0.897125
SLC12A9 solute carrier family 12, member 9 0.88185
FADS1 fatty acid desaturase 1 0.836775
C1ORF132 chromosome 1 open reading frame 132 0.820059
CADM2 cell adhesion molecule 2 0.819058
SRRT serrate, RNA effector molecule 0.731179
UFSP1 UFM1-specific peptidase 1 (non-functional) 0.731179
NFIA nuclear factor I/A 0.72315
SLC35F3 solute carrier family 35, member F3 0.67065
HEATR1 HEAT repeat containing 1 0.65974
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.656759
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.635963
ABHD12B abhydrolase domain containing 12B 0.62466
FAM149B1 family with sequence similarity 149, member B1 0.60867
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 0.60684
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 0.601679
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 0.57779
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 0.55712
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding) 0.552134
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 0.545504
TMEM44 transmembrane protein 44 0.527821
ARHGAP10 Rho GTPase activating protein 10 0.527821
PTPRG protein tyrosine phosphatase, receptor type, G 0.518003
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.50084
TEK TEK tyrosine kinase, endothelial 0.500347
TMEM135 transmembrane protein 135 0.491014
PADI3 peptidyl arginine deiminase, type III 0.490595
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.488686
TTN titin 0.443956
TSHZ2 teashirt zinc finger homeobox 2 0.442453
CNTN5 contactin 5 0.409186
CNTNAP2 contactin associated protein-like 2 0.398132
MAML2 mastermind-like 2 (Drosophila) 0.390053
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.38416
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.383267
KIAA1715 KIAA1715 0.382179
RBPMS RNA binding protein with multiple splicing 0.378873
RSL24D1P11 ribosomal L24 domain containing 1 pseudogene 11 0.375382
COL25A1 collagen, type XXV, alpha 1 0.365046
EHD4 EH-domain containing 4 0.325788
OSBP2 oxysterol binding protein 2 0.324793
DCLK1 doublecortin-like kinase 1 0.314199
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.313938
SMAD3 SMAD family member 3 0.312787
FABP7 fatty acid binding protein 7, brain 0.295458
CA10 carbonic anhydrase X 0.289774
EFNA5 ephrin-A5 0.287422
ARRB1 arrestin, beta 1 0.285059
TMEM131 transmembrane protein 131 0.284715
PRKG1 protein kinase, cGMP-dependent, type I 0.275355
MAPK1 mitogen-activated protein kinase 1 0.273339
ZNF385D zinc finger protein 385D 0.266973
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.266907
UBE3A ubiquitin protein ligase E3A 0.262365
DOCK4 dedicator of cytokinesis 4 0.260093
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.256513
CXCL9 chemokine (C-X-C motif) ligand 9 0.254113
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.251114
THSD7B thrombospondin, type I, domain containing 7B 0.250815
C15ORF32 chromosome 15 open reading frame 32 0.244332
CHD6 chromodomain helicase DNA binding protein 6 0.241663
KIAA1549L KIAA1549-like 0.239478
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.238169
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.233833
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.227715
TP73 tumor protein p73 0.225049
WDR86 WD repeat domain 86 0.224911
LGALS4 lectin, galactoside-binding, soluble, 4 0.223727
LDAH lipid droplet associated hydrolase 0.217179
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.214925
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.213881
DST dystonin 0.209512
NCEH1 neutral cholesterol ester hydrolase 1 0.205318
TK1 thymidine kinase 1, soluble 0.201739
PTK2 protein tyrosine kinase 2 0.200897
MAP2 microtubule-associated protein 2 0.196425
ANKRD33B ankyrin repeat domain 33B 0.193374
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.191745
MBD5 methyl-CpG binding domain protein 5 0.19171
XIRP2 xin actin binding repeat containing 2 0.188669
LPCAT4 lysophosphatidylcholine acyltransferase 4 0.185861
ZFPM2 zinc finger protein, FOG family member 2 0.185427
PARP12 poly (ADP-ribose) polymerase family, member 12 0.174863
DPP6 dipeptidyl-peptidase 6 0.163517
VWA3B von Willebrand factor A domain containing 3B 0.158765
WBSCR17 Williams-Beuren syndrome chromosome region 17 0.156311
EBF1 early B-cell factor 1 0.155582
SLC38A8 solute carrier family 38, member 8 0.154334
FBXL17 F-box and leucine-rich repeat protein 17 0.153684
CSMD1 CUB and Sushi multiple domains 1 0.153511
RALYL RALY RNA binding protein-like 0.152669
C1ORF229 chromosome 1 open reading frame 229 0.152109
TENM4 teneurin transmembrane protein 4 0.151839
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.145911
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.145883
MCPH1 microcephalin 1 0.14429
RAD51B RAD51 paralog B 0.143628
LAMA1 laminin, alpha 1 0.143297
KLHL21 kelch-like family member 21 0.141585
MTPN myotrophin 0.141048
LUZP6 leucine zipper protein 6 0.141048
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 0.137705
KLHL1 kelch-like family member 1 0.133358
ALK anaplastic lymphoma receptor tyrosine kinase 0.132327
TGFB2 transforming growth factor, beta 2 0.130848
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.128521
TMEM87B transmembrane protein 87B 0.121147
LINGO2 leucine rich repeat and Ig domain containing 2 0.12108
ARMC3 armadillo repeat containing 3 0.116929
NCOA1 nuclear receptor coactivator 1 0.114347
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.110752
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.106926
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.106237
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.103401
FNDC9 fibronectin type III domain containing 9 0.103401
RAB40C RAB40C, member RAS oncogene family 0.103179
EML6 echinoderm microtubule associated protein like 6 0.10217
ACTA2 actin, alpha 2, smooth muscle, aorta 0.100114
SGCZ sarcoglycan, zeta 0.09861
VPREB1 pre-B lymphocyte 1 0.09478
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.094394
MGAT4C MGAT4 family, member C 0.093808
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.093808
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.093222
FBXO15 F-box protein 15 0.089416
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 0.089011
SSUH2 ssu-2 homolog (C. elegans) 0.086459
LAMB1 laminin, beta 1 0.083735
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.083653
FAS Fas cell surface death receptor 0.079798
TMEM232 transmembrane protein 232 0.074731
BRD2 bromodomain containing 2 0.073951
RNLS renalase, FAD-dependent amine oxidase 0.073479
ANTXR1 anthrax toxin receptor 1 0.072258
MORF4L1 mortality factor 4 like 1 0.071736
ZNF516 zinc finger protein 516 0.070587
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.069031
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.068665
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.068311
CLMN calmin (calponin-like, transmembrane) 0.068247
CPQ carboxypeptidase Q 0.068035
NCALD neurocalcin delta 0.06787
TRIM67 tripartite motif containing 67 0.06746
OPCML opioid binding protein/cell adhesion molecule-like 0.065681
DLG2 discs, large homolog 2 (Drosophila) 0.065327
GRM5 glutamate receptor, metabotropic 5 0.065222
C10ORF55 chromosome 10 open reading frame 55 0.063329
ACYP2 acylphosphatase 2, muscle type 0.062082
TRPM5 transient receptor potential cation channel, subfamily M, member 5 0.062048
FAXC failed axon connections homolog (Drosophila) 0.061705
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.060924
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.060792
CMYA5 cardiomyopathy associated 5 0.060282