Heart Failure Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description disease cluster belonging to disease group cardiovascular (Genetic Association Database)
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Genes

187 genes associated with the trait Heart Failure in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 0.519354
GAS8 growth arrest-specific 8 0.391508
EGFLAM EGF-like, fibronectin type III and laminin G domains 0.384981
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.33862
TUBGCP3 tubulin, gamma complex associated protein 3 0.32232
RANBP17 RAN binding protein 17 0.320496
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.31566
TRIM33 tripartite motif containing 33 0.268856
CPM carboxypeptidase M 0.266045
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 0.260045
TRA T cell receptor alpha locus 0.250515
CNGB3 cyclic nucleotide gated channel beta 3 0.189224
CNOT2 CCR4-NOT transcription complex, subunit 2 0.188283
SFSWAP splicing factor, suppressor of white-apricot family 0.176091
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.174806
GPR137C G protein-coupled receptor 137C 0.172998
CPNE7 copine VII 0.15266
DBN1 drebrin 1 0.145122
SULF2 sulfatase 2 0.099985
CCNJL cyclin J-like 0.097814
KRT74 keratin 74, type II 0.091138
MALRD1 MAM and LDL receptor class A domain containing 1 0.083073
GPR39 G protein-coupled receptor 39 0.079983
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.078164
FOXN3 forkhead box N3 0.07337
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.067805
SCIN scinderin 0.067716
BMP6 bone morphogenetic protein 6 0.065647
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.063631
VSTM1 V-set and transmembrane domain containing 1 0.062684
TENM2 teneurin transmembrane protein 2 0.0597
TTC6 tetratricopeptide repeat domain 6 0.051159
SERPINA13P serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 13, pseudogene 0.051103
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.04891
PTPRD protein tyrosine phosphatase, receptor type, D 0.04828
SYNJ2 synaptojanin 2 0.046402
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.038958
MTUS2 microtubule associated tumor suppressor candidate 2 0.036809
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.033762
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.033322
FOCAD focadhesin 0.030612
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.030531
CAMTA1 calmodulin binding transcription activator 1 0.030287
KIAA1468 KIAA1468 0.030225
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.02807
KCNU1 potassium channel, subfamily U, member 1 0.027771
LAMC3 laminin, gamma 3 0.025695
STXBP5 syntaxin binding protein 5 (tomosyn) 0.024468
UPB1 ureidopropionase, beta 0.023284
MECOM MDS1 and EVI1 complex locus 0.023233
NCOA7 nuclear receptor coactivator 7 0.022787
GPATCH2 G patch domain containing 2 0.021428
CNTN5 contactin 5 0.021037
ADCY9 adenylate cyclase 9 0.020511
CELF2 CUGBP, Elav-like family member 2 0.020002
DOCK2 dedicator of cytokinesis 2 0.019769
IGL immunoglobulin lambda locus 0.019687
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.019387
C9ORF171 chromosome 9 open reading frame 171 0.019298
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 0.019039
C7 complement component 7 0.01833
ANKRD11 ankyrin repeat domain 11 0.018184
ETAA1 Ewing tumor-associated antigen 1 0.018146
ERLEC1P1 endoplasmic reticulum lectin 1 pseudogene 1 0.017742
FBXL7 F-box and leucine-rich repeat protein 7 0.017572
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.01747
ATE1 arginyltransferase 1 0.017238
TGFBR3 transforming growth factor, beta receptor III 0.017054
TNS1 tensin 1 0.01692
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.016803
GLI3 GLI family zinc finger 3 0.01654
CLU clusterin 0.016447
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.016152
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.015992
POU2AF1 POU class 2 associating factor 1 0.015845
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 0.015833
PTHLH parathyroid hormone-like hormone 0.015784
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.015718
KIRREL3 kin of IRRE like 3 (Drosophila) 0.015419
ARSG arylsulfatase G 0.015096
LRRC69 leucine rich repeat containing 69 0.014776
NTM neurotrimin 0.01477
ANO4 anoctamin 4 0.014583
DOCK8 dedicator of cytokinesis 8 0.014526
C9ORF66 chromosome 9 open reading frame 66 0.014526
STRN3 striatin, calmodulin binding protein 3 0.014438
HCFC2 host cell factor C2 0.013935
ACO1 aconitase 1, soluble 0.013788
ANPEP alanyl (membrane) aminopeptidase 0.013726
E2F3 E2F transcription factor 3 0.013654
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 0.012895
BIVM basic, immunoglobulin-like variable motif containing 0.012789
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.01265
BMPER BMP binding endothelial regulator 0.01255
NLRP4 NLR family, pyrin domain containing 4 0.012484
SPEN spen family transcriptional repressor 0.012106
ATXN1 ataxin 1 0.011682
CFAP61 cilia and flagella associated protein 61 0.011557
CRNKL1 crooked neck pre-mRNA splicing factor 1 0.011557
NALCN sodium leak channel, non selective 0.011536
MYLKP1 myosin light chain kinase pseudogene 1 (functional) 0.011174
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.010966
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.010887
LMNTD1 lamin tail domain containing 1 0.010669
ERICH3 glutamate-rich 3 0.010657
STXBP6 syntaxin binding protein 6 (amisyn) 0.010553
PLCL2 phospholipase C-like 2 0.010336
CABIN1 calcineurin binding protein 1 0.010176
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.010144
DOCK9 dedicator of cytokinesis 9 0.010134
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 0.009948
KDM4C lysine (K)-specific demethylase 4C 0.009872
ADAM19 ADAM metallopeptidase domain 19 0.009837
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.009708
CDH13 cadherin 13 0.009689
SMYD3 SET and MYND domain containing 3 0.009665
NIPAL4 NIPA-like domain containing 4 0.009478
USP22 ubiquitin specific peptidase 22 0.009415
CDK10 cyclin-dependent kinase 10 0.009361
SDK1 sidekick cell adhesion molecule 1 0.009344
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.009283
KIAA1217 KIAA1217 0.009197
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.009111
TRAPPC11 trafficking protein particle complex 11 0.009077
AK5 adenylate kinase 5 0.009063
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.008846
HCP5 HLA complex P5 (non-protein coding) 0.008777
ADGRE1 adhesion G protein-coupled receptor E1 0.008634
LARGE like-glycosyltransferase 0.008494
STAMBPL1 STAM binding protein-like 1 0.008446
PRDM7 PR domain containing 7 0.008348
FGF14 fibroblast growth factor 14 0.008144
ARHGAP15 Rho GTPase activating protein 15 0.008142
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.008137
FHIT fragile histidine triad 0.007878
LINC00476 long intergenic non-protein coding RNA 476 0.007716
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.007631
MPPED2 metallophosphoesterase domain containing 2 0.007589
SERAC1 serine active site containing 1 0.00753
RGS5 regulator of G-protein signaling 5 0.00747
PLXDC2 plexin domain containing 2 0.007434
NXPH2 neurexophilin 2 0.007255
CNTNAP2 contactin associated protein-like 2 0.007191
FRMD6 FERM domain containing 6 0.007051
AHCYL2 adenosylhomocysteinase-like 2 0.007003
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 0.006805
LIFR leukemia inhibitory factor receptor alpha 0.006591
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.006303
LYST lysosomal trafficking regulator 0.006256
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 0.006129
DCLK2 doublecortin-like kinase 2 0.006099
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.006047
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.005892
RASGEF1C RasGEF domain family, member 1C 0.005728
AKAP7 A kinase (PRKA) anchor protein 7 0.005639
TRAPPC9 trafficking protein particle complex 9 0.005434
OSM oncostatin M 0.005342
MOB3B MOB kinase activator 3B 0.005217
GRID2 glutamate receptor, ionotropic, delta 2 0.005188
C1QTNF6 C1q and tumor necrosis factor related protein 6 0.005176
GAP43 growth associated protein 43 0.00513
SRFBP1 serum response factor binding protein 1 0.004964
NLRP9 NLR family, pyrin domain containing 9 0.004876
STK32A serine/threonine kinase 32A 0.004793
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.004765
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.004758
SYCP1 synaptonemal complex protein 1 0.004748
NVL nuclear VCP-like 0.004708
JADE2 jade family PHD finger 2 0.004637
AATK apoptosis-associated tyrosine kinase 0.004636
SDF2L1 stromal cell-derived factor 2-like 1 0.00463
RCL1 RNA terminal phosphate cyclase-like 1 0.00463
DLG2 discs, large homolog 2 (Drosophila) 0.004429
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.004403
SLC35F1 solute carrier family 35, member F1 0.004399
ANK2 ankyrin 2, neuronal 0.004381
CCDC108 coiled-coil domain containing 108 0.004342
IQSEC3 IQ motif and Sec7 domain 3 0.004327
MYO16 myosin XVI 0.004323
FAM135B family with sequence similarity 135, member B 0.004311
MUC16 mucin 16, cell surface associated 0.004147
TBC1D5 TBC1 domain family, member 5 0.004076
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.004068
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.004051
VWA3B von Willebrand factor A domain containing 3B 0.004042
CDH10 cadherin 10, type 2 (T2-cadherin) 0.003837
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.003814