Heart Diseases Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

112 genes associated with the Heart Diseases phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACE angiotensin I converting enzyme
ACVRL1 activin A receptor type II-like 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMPD1 adenosine monophosphate deaminase 1
APOC3 apolipoprotein C-III
APOE apolipoprotein E
AR androgen receptor
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRAF B-Raf proto-oncogene, serine/threonine kinase
C6ORF10 chromosome 6 open reading frame 10
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CBR1 carbonyl reductase 1
CBS cystathionine-beta-synthase
CCL5 chemokine (C-C motif) ligand 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CETP cholesteryl ester transfer protein, plasma
CHD7 chromodomain helicase DNA binding protein 7
CHRM2 cholinergic receptor, muscarinic 2
CLCN6 chloride channel, voltage-sensitive 6
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CSMD2 CUB and Sushi multiple domains 2
CYBA cytochrome b-245, alpha polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DLC1 DLC1 Rho GTPase activating protein
ECE1 endothelin converting enzyme 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
EXOC4 exocyst complex component 4
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGF9 fibroblast growth factor 9
FMO2 flavin containing monooxygenase 2 (non-functional)
GAA glucosidase, alpha; acid
GATA4 GATA binding protein 4
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPC5 glypican 5
GPR37L1 G protein-coupled receptor 37 like 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HFE hemochromatosis
HNMT histamine N-methyltransferase
HRAS Harvey rat sarcoma viral oncogene homolog
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IFNG interferon, gamma
IL10 interleukin 10
IL18 interleukin 18
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KL klotho
KRAS Kirsten rat sarcoma viral oncogene homolog
LGALS8 lectin, galactoside-binding, soluble, 8
LIN9 lin-9 DREAM MuvB core complex component
LIPC lipase, hepatic
LPL lipoprotein lipase
LRGUK leucine-rich repeats and guanylate kinase domain containing
LRP2 low density lipoprotein receptor-related protein 2
MICB MHC class I polypeptide-related sequence B
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MT-TL1 tRNA
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPR1 natriuretic peptide receptor 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PCSK5 proprotein convertase subtilisin/kexin type 5
PDE4D phosphodiesterase 4D, cAMP-specific
PON1 paraoxonase 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
SCN5A sodium channel, voltage gated, type V alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SOS1 son of sevenless homolog 1 (Drosophila)
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
STX18 syntaxin 18
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TTR transthyretin
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
VCAM1 vascular cell adhesion molecule 1
VKORC1 vitamin K epoxide reductase complex, subunit 1
VWF von Willebrand factor
ZNF133 zinc finger protein 133
ZNF592 zinc finger protein 592