Heart Block Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Impaired conduction of cardiac impulse occurring anywhere along the conduction pathway. (Human Phenotype Ontology, HP_0012722)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D006327
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Genes

121 genes/proteins associated with the disease Heart Block from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
LMNA lamin A/C 2.88009
SCN10A sodium channel, voltage gated, type X alpha subunit 2.88009
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.32628
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.32279
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.30235
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.21687
FOS FBJ murine osteosarcoma viral oncogene homolog 2.14419
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.14005
TNF tumor necrosis factor 2.12761
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.99179
BCL2 B-cell CLL/lymphoma 2 1.98224
IL6 interleukin 6 1.97288
CAT catalase 1.89153
ADRB1 adrenoceptor beta 1 1.88819
NOS2 nitric oxide synthase 2, inducible 1.88159
REN renin 1.87842
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.8648
IL1B interleukin 1, beta 1.85782
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.80529
MAPK3 mitogen-activated protein kinase 3 1.77705
MAPK1 mitogen-activated protein kinase 1 1.76655
BAX BCL2-associated X protein 1.7652
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.73089
CCL2 chemokine (C-C motif) ligand 2 1.72034
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.70595
POMC proopiomelanocortin 1.65731
ADRB2 adrenoceptor beta 2, surface 1.61967
VEGFA vascular endothelial growth factor A 1.58889
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.57853
NPPA natriuretic peptide A 1.57402
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.53941
IL10 interleukin 10 1.53159
PRL prolactin 1.51936
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.50172
CXCL8 chemokine (C-X-C motif) ligand 8 1.49941
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.4794
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.45089
TP53 tumor protein p53 1.43564
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.41911
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.39869
CRH corticotropin releasing hormone 1.39646
BDNF brain-derived neurotrophic factor 1.39142
C10ORF10 chromosome 10 open reading frame 10 1.38807
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.38412
EGR1 early growth response 1 1.38327
IFNG interferon, gamma 1.38128
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.37987
NUPR1 nuclear protein, transcriptional regulator, 1 1.36905
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.36876
BCL2L1 BCL2-like 1 1.36791
SOD1 superoxide dismutase 1, soluble 1.36562
GSTP1 glutathione S-transferase pi 1 1.35705
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.34372
TAC1 tachykinin, precursor 1 1.3414
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.34082
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.33761
AVP arginine vasopressin 1.32964
PARP1 poly (ADP-ribose) polymerase 1 1.32577
ADRB3 adrenoceptor beta 3 1.29502
CALCA calcitonin-related polypeptide alpha 1.29471
HPN hepsin 1.2941
NPPB natriuretic peptide B 1.28364
FABP1 fatty acid binding protein 1, liver 1.28364
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.28333
FAS Fas cell surface death receptor 1.28241
CREB1 cAMP responsive element binding protein 1 1.28088
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.28058
INHBE inhibin, beta E 1.28058
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.27471
GJA1 gap junction protein, alpha 1, 43kDa 1.26421
JUN jun proto-oncogene 1.25338
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.2475
FNDC4 fibronectin type III domain containing 4 1.24181
EGFR epidermal growth factor receptor 1.23392
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.23265
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.23074
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.22501
MAPK8 mitogen-activated protein kinase 8 1.2137
TAGLN transgelin 1.21304
GNAS GNAS complex locus 1.21076
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.20558
DRD2 dopamine receptor D2 1.19868
TGFB1 transforming growth factor, beta 1 1.19737
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.19672
S100A9 S100 calcium binding protein A9 1.19477
HMOX1 heme oxygenase 1 1.1862
PENK proenkephalin 1.173
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.17067
GAL galanin/GMAP prepropeptide 1.16833
EDN1 endothelin 1 1.16401
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.15899
MPO myeloperoxidase 1.15763
CCND1 cyclin D1 1.15391
ADRA2A adrenoceptor alpha 2A 1.15357
CLU clusterin 1.1437
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.1437
NPY neuropeptide Y 1.13655
DRD1 dopamine receptor D1 1.13279
NOS3 nitric oxide synthase 3 (endothelial cell) 1.13041
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.12082
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.11775
TH tyrosine hydroxylase 1.11466
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.10631
CREM cAMP responsive element modulator 1.10493
C3 complement component 3 1.10388
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.09998
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.09366
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.08762
NOS1 nitric oxide synthase 1 (neuronal) 1.07057
IL1A interleukin 1, alpha 1.06552
IL2 interleukin 2 1.06188
INS insulin 1.05423
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.052
SOD2 superoxide dismutase 2, mitochondrial 1.05052
IGF1 insulin-like growth factor 1 (somatomedin C) 1.04684
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.04276
NGF nerve growth factor (beta polypeptide) 1.04201
DDIT3 DNA-damage-inducible transcript 3 1.03827
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.03345
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.02559
IL4 interleukin 4 1.01966