Hearing Loss Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced ability to perceive auditory stimuli (Mammalian Phenotype Ontology, MP_0006325)
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Genes

135 genes associated with the Hearing Loss phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AOX1 aldehyde oxidase 1
APOE apolipoprotein E
CASP1 caspase 1, apoptosis-related cysteine peptidase
CDA cytidine deaminase
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLCN6 chloride channel, voltage-sensitive 6
CLDN14 claudin 14
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
COMT catechol-O-methyltransferase
CRYL1 crystallin, lambda 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1
DFNA5 deafness, autosomal dominant 5
DFNB13 deafness, autosomal recessive 13
DFNB59 deafness, autosomal recessive 59
DHFR dihydrofolate reductase
DPYD dihydropyrimidine dehydrogenase
EDN1 endothelin 1
EPHA2 EPH receptor A2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ESPN espin
ESRRG estrogen-related receptor gamma
FLG filaggrin
FMO1 flavin containing monooxygenase 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FMO3 flavin containing monooxygenase 3
FMO4 flavin containing monooxygenase 4
FMO5 flavin containing monooxygenase 5
FMO6P flavin containing monooxygenase 6 pseudogene
GJA1 gap junction protein, alpha 1, 43kDa
GJB2 gap junction protein, beta 2, 26kDa
GJB3 gap junction protein, beta 3, 31kDa
GJB4 gap junction protein, beta 4, 30.3kDa
GJB6 gap junction protein, beta 6, 30kDa
GJC1 gap junction protein, gamma 1, 45kDa
GJC3 gap junction protein, gamma 3, 30.2kDa
GRM7 glutamate receptor, metabotropic 7
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTM4 glutathione S-transferase mu 4
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HLA-B major histocompatibility complex, class I, B
HNMT histamine N-methyltransferase
HOXA2 homeobox A2
IQGAP2 IQ motif containing GTPase activating protein 2
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4
LRP2 low density lipoprotein receptor-related protein 2
METAP1 methionyl aminopeptidase 1
MICA MHC class I polypeptide-related sequence A
MIR96 microRNA 96
MT-TH tRNA
MT-TK tRNA
MT-TL1 tRNA
MT-TL2 tRNA
MT-TQ tRNA
MT-TS1 tRNA
MT-TS2 tRNA
MT-TV tRNA
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYO1A myosin IA
MYO6 myosin VI
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
OTOF otoferlin
PCDH15 protocadherin-related 15
PPARG peroxisome proliferator-activated receptor gamma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
SGOL2 shugoshin-like 2 (S. pombe)
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC26A5 solute carrier family 26 (anion exchanger), member 5
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOD2 superoxide dismutase 2, mitochondrial
SOS1 son of sevenless homolog 1 (Drosophila)
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TECTA tectorin alpha
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TMC1 transmembrane channel-like 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPMT thiopurine S-methyltransferase
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A2P UDP glucuronosyltransferase 1 family, polypeptide A2 pseudogene
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
UGT8 UDP glycosyltransferase 8
USH2A Usher syndrome 2A (autosomal recessive, mild)
WFS1 Wolfram syndrome 1 (wolframin)
XDH xanthine dehydrogenase
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C