HAND1 Gene Set

Dataset TRANSFAC Curated Transcription Factor Targets
Category genomics
Type transcription factor
Description heart and neural crest derivatives expressed 1|The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9421)
External Link http://www.ncbi.nlm.nih.gov/gene/9421
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Genes

272 target genes of the HAND1 transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

Symbol Name
ABLIM1 actin binding LIM protein 1
ACAD11 acyl-CoA dehydrogenase family, member 11
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM11 ADAM metallopeptidase domain 11
ADCY6 adenylate cyclase 6
AGR3 anterior gradient 3
ALPK2 alpha-kinase 2
AMMECR1L AMMECR1-like
ANGPTL6 angiopoietin-like 6
ANK1 ankyrin 1, erythrocytic
ANKRD17 ankyrin repeat domain 17
ARHGAP6 Rho GTPase activating protein 6
ARMCX1 armadillo repeat containing, X-linked 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
ATXN1 ataxin 1
BAMBI BMP and activin membrane-bound inhibitor
BBS12 Bardet-Biedl syndrome 12
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEST2 bestrophin 2
BHLHE40 basic helix-loop-helix family, member e40
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BTBD3 BTB (POZ) domain containing 3
C10ORF11 chromosome 10 open reading frame 11
C10ORF71 chromosome 10 open reading frame 71
C11ORF48
C12ORF50 chromosome 12 open reading frame 50
C16ORF47 chromosome 16 open reading frame 47
C17ORF102 chromosome 17 open reading frame 102
C1ORF122 chromosome 1 open reading frame 122
C22ORF31 chromosome 22 open reading frame 31
C2CD2L C2CD2-like
C4ORF26 chromosome 4 open reading frame 26
C4ORF32 chromosome 4 open reading frame 32
C5ORF42 chromosome 5 open reading frame 42
C7 complement component 7
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH10 cadherin 10, type 2 (T2-cadherin)
CDK2 cyclin-dependent kinase 2
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CELF3 CUGBP, Elav-like family member 3
CEP44 centrosomal protein 44kDa
CLC Charcot-Leyden crystal galectin
CLVS1 clavesin 1
CNTLN centlein, centrosomal protein
COL12A1 collagen, type XII, alpha 1
COL27A1 collagen, type XXVII, alpha 1
COMMD1 copper metabolism (Murr1) domain containing 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CREB5 cAMP responsive element binding protein 5
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
CTNNA3 catenin (cadherin-associated protein), alpha 3
CXXC5 CXXC finger protein 5
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DCDC5 doublecortin domain containing 5
DCHS2 dachsous cadherin-related 2
DCX doublecortin
DDIT4L DNA-damage-inducible transcript 4-like
DLC1 DLC1 Rho GTPase activating protein
DLX5 distal-less homeobox 5
DMBT1 deleted in malignant brain tumors 1
DMD dystrophin
DMTN dematin actin binding protein
DPYSL2 dihydropyrimidinase-like 2
DUSP5 dual specificity phosphatase 5
DVL3 dishevelled segment polarity protein 3
EBF2 early B-cell factor 2
ECHDC2 enoyl CoA hydratase domain containing 2
EDN1 endothelin 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ELAVL4 ELAV like neuron-specific RNA binding protein 4
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ELMO1 engulfment and cell motility 1
ELP4 elongator acetyltransferase complex subunit 4
EMID1 EMI domain containing 1
EML4 echinoderm microtubule associated protein like 4
ENDOU endonuclease, polyU-specific
EP300 E1A binding protein p300
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM46A family with sequence similarity 46, member A
FAM91A1 family with sequence similarity 91, member A1
FBXL14 F-box and leucine-rich repeat protein 14
FBXL19 F-box and leucine-rich repeat protein 19
FBXO8 F-box protein 8
FBXW4 F-box and WD repeat domain containing 4
FER1L6-AS1 FER1L6 antisense RNA 1
FERD3L Fer3-like bHLH transcription factor
FZD1 frizzled class receptor 1
GDF7 growth differentiation factor 7
GGT6 gamma-glutamyltransferase 6
GLRA1 glycine receptor, alpha 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GOLGA7 golgin A7
GPR173 G protein-coupled receptor 173
GPR19 G protein-coupled receptor 19
GPR37L1 G protein-coupled receptor 37 like 1
GRHL3 grainyhead-like 3 (Drosophila)
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GSK3B glycogen synthase kinase 3 beta
HAS2 hyaluronan synthase 2
HOXA6 homeobox A6
HOXB13 homeobox B13
HOXB6 homeobox B6
HOXC6 homeobox C6
HRH3 histamine receptor H3
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HYPK huntingtin interacting protein K
IL11RA interleukin 11 receptor, alpha
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
ITGA1 integrin, alpha 1
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
JPH1 junctophilin 1
KANSL3 KAT8 regulatory NSL complex subunit 3
KDM3B lysine (K)-specific demethylase 3B
KLF5 Kruppel-like factor 5 (intestinal)
KLHL10 kelch-like family member 10
LAPTM4A lysosomal protein transmembrane 4 alpha
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEMD1 LEM domain containing 1
LGI1 leucine-rich, glioma inactivated 1
LHX1 LIM homeobox 1
LINC01465 long intergenic non-protein coding RNA 1465
LIX1 Lix1 homolog (chicken)
LIX1L Lix1 homolog (chicken) like
LMO2 LIM domain only 2 (rhombotin-like 1)
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
LONRF3 LON peptidase N-terminal domain and ring finger 3
LPL lipoprotein lipase
LRRC75A-AS1 LRRC75A antisense RNA 1
LRRTM4 leucine rich repeat transmembrane neuronal 4
LY86 lymphocyte antigen 86
MAB21L2 mab-21-like 2 (C. elegans)
MAMDC2 MAM domain containing 2
MAPK3 mitogen-activated protein kinase 3
MBNL1 muscleblind-like splicing regulator 1
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
MKL1 megakaryoblastic leukemia (translocation) 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRPS18B mitochondrial ribosomal protein S18B
MTF2 metal response element binding transcription factor 2
MUSK muscle, skeletal, receptor tyrosine kinase
MYH4 myosin, heavy chain 4, skeletal muscle
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYT1 myelin transcription factor 1
NCDN neurochondrin
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NEUROD6 neuronal differentiation 6
NEUROG2 neurogenin 2
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NGEF neuronal guanine nucleotide exchange factor
NKAIN3 Na+/K+ transporting ATPase interacting 3
NKX2-3 NK2 homeobox 3
NOG noggin
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRG1 neuregulin 1
NRK Nik related kinase
NT5C3B 5'-nucleotidase, cytosolic IIIB
NUB1 negative regulator of ubiquitin-like proteins 1
NUBP2 nucleotide binding protein 2
NYX nyctalopin
OFCC1 orofacial cleft 1 candidate 1
OGDHL oxoglutarate dehydrogenase-like
PAK1IP1 PAK1 interacting protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDZD9 PDZ domain containing 9
PELO pelota homolog (Drosophila)
PHF3 PHD finger protein 3
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein
PI16 peptidase inhibitor 16
PIANP PILR alpha associated neural protein
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PMEL premelanosome protein
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POU2F1 POU class 2 homeobox 1
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRKCH protein kinase C, eta
PTCHD1 patched domain containing 1
PTK6 protein tyrosine kinase 6
PTMS parathymosin
PURA purine-rich element binding protein A
PURG purine-rich element binding protein G
PWWP2B PWWP domain containing 2B
RAB10 RAB10, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RAG2 recombination activating gene 2
RBM33 RNA binding motif protein 33
RBMS3 RNA binding motif, single stranded interacting protein 3
RCOR2 REST corepressor 2
RIT2 Ras-like without CAAX 2
RNF112 ring finger protein 112
RNF113A ring finger protein 113A
RNF25 ring finger protein 25
RPS6KL1 ribosomal protein S6 kinase-like 1
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae)
RSPO2 R-spondin 2
RTN2 reticulon 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RWDD1 RWD domain containing 1
S100A10 S100 calcium binding protein A10
SAG S-antigen; retina and pineal gland (arrestin)
SBSPON somatomedin B and thrombospondin, type 1 domain containing
SELL selectin L
SEPT4 septin 4
SERTAD4 SERTA domain containing 4
SLC12A8 solute carrier family 12, member 8
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC38A11 solute carrier family 38, member 11
SLIT3 slit homolog 3 (Drosophila)
SLN sarcolipin
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX5 SRY (sex determining region Y)-box 5
SPOP speckle-type POZ protein
ST13P4 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 4
STAG1 stromal antigen 1
STAT5B signal transducer and activator of transcription 5B
STAU1 staufen double-stranded RNA binding protein 1
STC1 stanniocalcin 1
STK36 serine/threonine kinase 36
STMN1 stathmin 1
STX18 syntaxin 18
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
SYT16 synaptotagmin XVI
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAL2 T-cell acute lymphocytic leukemia 2
TAT tyrosine aminotransferase
TC2N tandem C2 domains, nuclear
TENM1 teneurin transmembrane protein 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGFBR1 transforming growth factor, beta receptor 1
TMCC1 transmembrane and coiled-coil domain family 1
TMEM204 transmembrane protein 204
TMPO thymopoietin
TNKS1BP1 tankyrase 1 binding protein 1, 182kDa
TPGS1 tubulin polyglutamylase complex subunit 1
TSHZ2 teashirt zinc finger homeobox 2
UBA5 ubiquitin-like modifier activating enzyme 5
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2E1 ubiquitin-conjugating enzyme E2E 1
USP49 ubiquitin specific peptidase 49
USP51 ubiquitin specific peptidase 51
UTS2 urotensin 2
VGF VGF nerve growth factor inducible
VIP vasoactive intestinal peptide
VWA5B1 von Willebrand factor A domain containing 5B1
VWF von Willebrand factor
WDR5B WD repeat domain 5B
WNT2B wingless-type MMTV integration site family, member 2B
WNT8B wingless-type MMTV integration site family, member 8B
WNT9A wingless-type MMTV integration site family, member 9A
WRN Werner syndrome, RecQ helicase-like
XCR1 chemokine (C motif) receptor 1
XKRX XK, Kell blood group complex subunit-related, X-linked
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC1 zinc finger, DHHC-type containing 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF462 zinc finger protein 462
ZSWIM8 zinc finger, SWIM-type containing 8