H-89-6873 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the H-89-6873 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACACA acetyl-CoA carboxylase alpha
ADGB androglobin
ALPPL2 alkaline phosphatase, placental-like 2
APOL6 apolipoprotein L, 6
ARMC8 armadillo repeat containing 8
ASB7 ankyrin repeat and SOCS box containing 7
ATXN2L ataxin 2-like
AURKC aurora kinase C
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CDK20 cyclin-dependent kinase 20
CDV3 CDV3 homolog (mouse)
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
F3 coagulation factor III (thromboplastin, tissue factor)
FABP6 fatty acid binding protein 6, ileal
FAM214B family with sequence similarity 214, member B
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GAN gigaxonin
GFOD2 glucose-fructose oxidoreductase domain containing 2
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLRA2 glycine receptor, alpha 2
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPATCH2L G patch domain containing 2-like
GRSF1 G-rich RNA sequence binding factor 1
GRTP1 growth hormone regulated TBC protein 1
GSK3A glycogen synthase kinase 3 alpha
HEMK1 HemK methyltransferase family member 1
HIST1H1T histone cluster 1, H1t
IGL immunoglobulin lambda locus
IL1RAP interleukin 1 receptor accessory protein
INCENP inner centromere protein antigens 135/155kDa
ITGB5 integrin, beta 5
KCNIP1 Kv channel interacting protein 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA1107 KIAA1107
KRT38 keratin 38, type I
KRT6B keratin 6B, type II
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LINC00094 long intergenic non-protein coding RNA 94
LPPR4 lipid phosphate phosphatase-related protein type 4
MAP2K6 mitogen-activated protein kinase kinase 6
MATN1 matrilin 1, cartilage matrix protein
MCFD2 multiple coagulation factor deficiency 2
MYL10 myosin, light chain 10, regulatory
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCAPH2 non-SMC condensin II complex, subunit H2
NCKAP1L NCK-associated protein 1-like
NEK3 NIMA-related kinase 3
NID2 nidogen 2 (osteonidogen)
NKX3-2 NK3 homeobox 2
NLGN4X neuroligin 4, X-linked
NOVA1 neuro-oncological ventral antigen 1
NRXN3 neurexin 3
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
PBX2 pre-B-cell leukemia homeobox 2
PCGF3 polycomb group ring finger 3
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRO2012 uncharacterized protein PRO2012
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RETN resistin
RHEB Ras homolog enriched in brain
RIMS2 regulating synaptic membrane exocytosis 2
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RUSC2 RUN and SH3 domain containing 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SETDB1 SET domain, bifurcated 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SRD5A3 steroid 5 alpha-reductase 3
ST20 suppressor of tumorigenicity 20
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBXA2R thromboxane A2 receptor
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRH thyrotropin-releasing hormone
UBA7 ubiquitin-like modifier activating enzyme 7
UNC93B1 unc-93 homolog B1 (C. elegans)
VWA5A von Willebrand factor A domain containing 5A
WSB1 WD repeat and SOCS box containing 1
YBX2 Y box binding protein 2
ZBTB17 zinc finger and BTB domain containing 17
ZBTB22 zinc finger and BTB domain containing 22
ZNF277 zinc finger protein 277
ZNF710 zinc finger protein 710
ZNF74 zinc finger protein 74
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTN4 actinin, alpha 4
ANP32A-IT1 ANP32A intronic transcript 1
BFSP1 beaded filament structural protein 1, filensin
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BRCA2 breast cancer 2, early onset
C11ORF63 chromosome 11 open reading frame 63
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC106 coiled-coil domain containing 106
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEP295 centrosomal protein 295kDa
CISH cytokine inducible SH2-containing protein
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COG7 component of oligomeric golgi complex 7
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CUZD1 CUB and zona pellucida-like domains 1
CXORF56 chromosome X open reading frame 56
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DENND5B DENN/MADD domain containing 5B
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EPHX2 epoxide hydrolase 2, cytoplasmic
ERI3 ERI1 exoribonuclease family member 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM155A family with sequence similarity 155, member A
FGF13 fibroblast growth factor 13
FLCN folliculin
GMEB1 glucocorticoid modulatory element binding protein 1
GREB1L growth regulation by estrogen in breast cancer-like
H2AFJ H2A histone family, member J
HAUS6 HAUS augmin-like complex, subunit 6
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BJ histone cluster 1, H2bj
HIST1H3G histone cluster 1, H3g
IFI6 interferon, alpha-inducible protein 6
IFT22 intraflagellar transport 22
IL20RA interleukin 20 receptor, alpha
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIAA0319L KIAA0319-like
KIFC3 kinesin family member C3
LIG3 ligase III, DNA, ATP-dependent
LRP5L low density lipoprotein receptor-related protein 5-like
MAGEF1 melanoma antigen family F1
METTL8 methyltransferase like 8
NAT6 N-acetyltransferase 6 (GCN5-related)
NOD1 nucleotide-binding oligomerization domain containing 1
NUP62CL nucleoporin 62kDa C-terminal like
NXPH3 neurexophilin 3
PAIP2B poly(A) binding protein interacting protein 2B
PAQR4 progestin and adipoQ receptor family member IV
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
POLL polymerase (DNA directed), lambda
POU3F2 POU class 3 homeobox 2
RAB4B RAB4B, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RBBP5 retinoblastoma binding protein 5
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNF126P1 ring finger protein 126 pseudogene 1
RNF31 ring finger protein 31
SERTAD3 SERTA domain containing 3
SETBP1 SET binding protein 1
SETD6 SET domain containing 6
SETD8 SET domain containing (lysine methyltransferase) 8
SIRT2 sirtuin 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMA4 glucuronidase, beta pseudogene
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPATA7 spermatogenesis associated 7
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK16 serine/threonine kinase 16
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TCTN1 tectonic family member 1
TENM1 teneurin transmembrane protein 1
TH tyrosine hydroxylase
THBS3 thrombospondin 3
TINAGL1 tubulointerstitial nephritis antigen-like 1
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTPAL tocopherol (alpha) transfer protein-like
TXLNG taxilin gamma
VASH1 vasohibin 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR46 WD repeat domain 46
WNT10B wingless-type MMTV integration site family, member 10B
ZBTB39 zinc finger and BTB domain containing 39
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF446 zinc finger protein 446
ZNF529 zinc finger protein 529
ZNF571 zinc finger protein 571
ZNF667 zinc finger protein 667
ZNF749 zinc finger protein 749