Glycosaminoglycan metabolism Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties. (Gene Ontology, GO_0030203)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-1630316
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Genes

121 proteins participating in the Glycosaminoglycan metabolism pathway from the Reactome Pathways dataset.

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACAN aggrecan
AGRN agrin
ARSB arylsulfatase B
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
B3GAT1 beta-1,3-glucuronyltransferase 1
B3GAT2 beta-1,3-glucuronyltransferase 2
B3GAT3 beta-1,3-glucuronyltransferase 3
B3GNT1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
B3GNT7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
BCAN brevican
BGN biglycan
CD44 CD44 molecule (Indian blood group)
CHP1 calcineurin-like EF-hand protein 1
CHPF chondroitin polymerizing factor
CHPF2 chondroitin polymerizing factor 2
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CHST13 carbohydrate (chondroitin 4) sulfotransferase 13
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
CHSY1 chondroitin sulfate synthase 1
CHSY3 chondroitin sulfate synthase 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSPG4 chondroitin sulfate proteoglycan 4
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
DCN decorin
DSE dermatan sulfate epimerase
DSEL dermatan sulfate epimerase-like
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
FMOD fibromodulin
GLB1 galactosidase, beta 1
GLB1L galactosidase, beta 1-like
GLCE glucuronic acid epimerase
GNS glucosamine (N-acetyl)-6-sulfatase
GPC1 glypican 1
GPC2 glypican 2
GPC3 glypican 3
GPC4 glypican 4
GPC5 glypican 5
GPC6 glypican 6
GUSB glucuronidase, beta
GXYLT1 glucoside xylosyltransferase 1
GXYLT2 glucoside xylosyltransferase 2
HAS1 hyaluronan synthase 1
HAS2 hyaluronan synthase 2
HAS3 hyaluronan synthase 3
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPSE heparanase
HPSE2 heparanase 2 (inactive)
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HS6ST2 heparan sulfate 6-O-sulfotransferase 2
HS6ST3 heparan sulfate 6-O-sulfotransferase 3
HSPG2 heparan sulfate proteoglycan 2
HYAL1 hyaluronoglucosaminidase 1
HYAL2 hyaluronoglucosaminidase 2
HYAL3 hyaluronoglucosaminidase 3
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
KERA keratocan
LUM lumican
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
NAGLU N-acetylglucosaminidase, alpha
NCAN neurocan
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
OGN osteoglycin
OMD osteomodulin
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PRELP proline/arginine-rich end leucine-rich repeat protein
SDC1 syndecan 1
SDC2 syndecan 2
SDC3 syndecan 3
SDC4 syndecan 4
SGSH N-sulfoglucosamine sulfohydrolase
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STAB2 stabilin 2
UST uronyl-2-sulfotransferase
VCAN versican