Gly-His-Lys-6575 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the Gly-His-Lys-6575 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ADK adenosine kinase
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
ATF2 activating transcription factor 2
ATP9A ATPase, class II, type 9A
BCL9 B-cell CLL/lymphoma 9
BICD1 bicaudal D homolog 1 (Drosophila)
BRWD1 bromodomain and WD repeat domain containing 1
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCNG2 cyclin G2
CCNO cyclin O
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDYL chromodomain protein, Y-like
CENPA centromere protein A
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLGN calmegin
COCH cochlin
CRABP1 cellular retinoic acid binding protein 1
CREB1 cAMP responsive element binding protein 1
CTNS cystinosin, lysosomal cystine transporter
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
DOCK1 dedicator of cytokinesis 1
DST dystonin
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
FAM86C1 family with sequence similarity 86, member C1
FAS Fas cell surface death receptor
FBXO42 F-box protein 42
FGFR1OP FGFR1 oncogene partner
FOXD1 forkhead box D1
FZD3 frizzled class receptor 3
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GCDH glutaryl-CoA dehydrogenase
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HAUS5 HAUS augmin-like complex, subunit 5
HDGFRP3 hepatoma-derived growth factor, related protein 3
ICK intestinal cell (MAK-like) kinase
IFT140 intraflagellar transport 140
INO80B INO80 complex subunit B
KATNBL1 katanin p80 subunit B-like 1
KDM4C lysine (K)-specific demethylase 4C
KIAA0125 KIAA0125
KLHL20 kelch-like family member 20
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHX2 LIM homeobox 2
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
LYST lysosomal trafficking regulator
MAPKBP1 mitogen-activated protein kinase binding protein 1
MED16 mediator complex subunit 16
MKRN2 makorin ring finger protein 2
MXD4 MAX dimerization protein 4
NCK1 NCK adaptor protein 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NEK1 NIMA-related kinase 1
NFYC nuclear transcription factor Y, gamma
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NPR2 natriuretic peptide receptor 2
NPY1R neuropeptide Y receptor Y1
PARVA parvin, alpha
PCGF2 polycomb group ring finger 2
PDE4DIP phosphodiesterase 4D interacting protein
PEX19 peroxisomal biogenesis factor 19
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
POFUT1 protein O-fucosyltransferase 1
POT1 protection of telomeres 1
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
REEP1 receptor accessory protein 1
RPP25 ribonuclease P/MRP 25kDa subunit
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
SCARB2 scavenger receptor class B, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SIGMAR1 sigma non-opioid intracellular receptor 1
SIRT3 sirtuin 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SNX3 sorting nexin 3
SOCS6 suppressor of cytokine signaling 6
STMN1 stathmin 1
STX2 syntaxin 2
STX5 syntaxin 5
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like
SYNRG synergin, gamma
TBC1D31 TBC1 domain family, member 31
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
THAP1 THAP domain containing, apoptosis associated protein 1
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)
TRIM66 tripartite motif containing 66
TUBA3C tubulin, alpha 3c
ZBTB22 zinc finger and BTB domain containing 22
ZFYVE26 zinc finger, FYVE domain containing 26
ZNF107 zinc finger protein 107
ZNF492 zinc finger protein 492
ZNF654 zinc finger protein 654

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ALG12 ALG12, alpha-1,6-mannosyltransferase
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARPIN actin-related protein 2/3 complex inhibitor
ATG7 autophagy related 7
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C11ORF30 chromosome 11 open reading frame 30
C11ORF80 chromosome 11 open reading frame 80
CAPG capping protein (actin filament), gelsolin-like
CCS copper chaperone for superoxide dismutase
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCN2 chloride channel, voltage-sensitive 2
COPZ2 coatomer protein complex, subunit zeta 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTSF cathepsin F
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DPY19L1P1 DPY19L1 pseudogene 1
EDC3 enhancer of mRNA decapping 3
FAM160B2 family with sequence similarity 160, member B2
FAM46C family with sequence similarity 46, member C
FBXL15 F-box and leucine-rich repeat protein 15
FBXO31 F-box protein 31
FMO4 flavin containing monooxygenase 4
FSTL3 follistatin-like 3 (secreted glycoprotein)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRTP1 growth hormone regulated TBC protein 1
HDAC7 histone deacetylase 7
HIST1H1D histone cluster 1, H1d
HIST1H3B histone cluster 1, H3b
IRF6 interferon regulatory factor 6
ISYNA1 inositol-3-phosphate synthase 1
KIAA1324 KIAA1324
KRT31 keratin 31, type I
LAMP3 lysosomal-associated membrane protein 3
LDB1 LIM domain binding 1
LGALS4 lectin, galactoside-binding, soluble, 4
LHX6 LIM homeobox 6
LINC00115 long intergenic non-protein coding RNA 115
LMCD1 LIM and cysteine-rich domains 1
LMNB1 lamin B1
LOC100287590 uncharacterized LOC100287590
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRP5 low density lipoprotein receptor-related protein 5
MAPK3 mitogen-activated protein kinase 3
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MRPL44 mitochondrial ribosomal protein L44
MVD mevalonate (diphospho) decarboxylase
MYO1F myosin IF
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5DC3 5'-nucleotidase domain containing 3
PADI1 peptidyl arginine deiminase, type I
PARP12 poly (ADP-ribose) polymerase family, member 12
PDLIM2 PDZ and LIM domain 2 (mystique)
PEX26 peroxisomal biogenesis factor 26
PGPEP1 pyroglutamyl-peptidase I
PLTP phospholipid transfer protein
POMT2 protein-O-mannosyltransferase 2
PPAP2C phosphatidic acid phosphatase type 2C
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRU protein tyrosine phosphatase, receptor type, U
QTRT1 queuine tRNA-ribosyltransferase 1
RANGRF RAN guanine nucleotide release factor
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RFPL3 ret finger protein-like 3
RNF121 ring finger protein 121
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SAA3P serum amyloid A3 pseudogene
SCYL2 SCY1-like 2 (S. cerevisiae)
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
STK16 serine/threonine kinase 16
TBC1D17 TBC1 domain family, member 17
TCTN1 tectonic family member 1
TMEM120B transmembrane protein 120B
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM68 tripartite motif containing 68
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBOX5 U-box domain containing 5
UBQLN4 ubiquilin 4
UBTD1 ubiquitin domain containing 1
UNC119 unc-119 homolog (C. elegans)
USP19 ubiquitin specific peptidase 19
USP20 ubiquitin specific peptidase 20
WBSCR16 Williams-Beuren syndrome chromosome region 16
XAB2 XPA binding protein 2
XK X-linked Kx blood group
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF205 zinc finger protein 205
ZNF551 zinc finger protein 551
ZNF816 zinc finger protein 816