Gly-His-Lys-6570 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Gly-His-Lys-6570 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTB actin, beta
AP1AR adaptor-related protein complex 1 associated regulatory protein
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
BMPR1A bone morphogenetic protein receptor, type IA
C16ORF59 chromosome 16 open reading frame 59
C6ORF62 chromosome 6 open reading frame 62
CALU calumenin
CDK2 cyclin-dependent kinase 2
CLIP1 CAP-GLY domain containing linker protein 1
COMMD10 COMM domain containing 10
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DBT dihydrolipoamide branched chain transacylase E2
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
F2RL1 coagulation factor II (thrombin) receptor-like 1
F8 coagulation factor VIII, procoagulant component
FH fumarate hydratase
FUS FUS RNA binding protein
FZD8 frizzled class receptor 8
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GALK2 galactokinase 2
GANAB glucosidase, alpha; neutral AB
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GDE1 glycerophosphodiester phosphodiesterase 1
GDI2 GDP dissociation inhibitor 2
GLS glutaminase
GLUD2 glutamate dehydrogenase 2
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPHN gephyrin
GRPR gastrin-releasing peptide receptor
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2AFX H2A histone family, member X
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KLHDC3 kelch domain containing 3
LRRC61 leucine rich repeat containing 61
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGEF1 melanoma antigen family F1
MAP4 microtubule-associated protein 4
MAT2A methionine adenosyltransferase II, alpha
MBTPS1 membrane-bound transcription factor peptidase, site 1
MED6 mediator complex subunit 6
MPZL1 myelin protein zero-like 1
MSH6 mutS homolog 6
NMD3 NMD3 ribosome export adaptor
NOTCH2 notch 2
NOV nephroblastoma overexpressed
OCRL oculocerebrorenal syndrome of Lowe
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAPOLA poly(A) polymerase alpha
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLAU plasminogen activator, urokinase
PLEC plectin
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POMT2 protein-O-mannosyltransferase 2
PPIF peptidylprolyl isomerase F
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRNP prion protein
PRPF4 pre-mRNA processing factor 4
PRR3 proline rich 3
PSAT1 phosphoserine aminotransferase 1
PSEN1 presenilin 1
RAB3B RAB3B, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RBBP4 retinoblastoma binding protein 4
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNF24 ring finger protein 24
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RUNX1-IT1 RUNX1 intronic transcript 1
SEC23A Sec23 homolog A (S. cerevisiae)
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SH2D4A SH2 domain containing 4A
SKA1 spindle and kinetochore associated complex subunit 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPAG9 sperm associated antigen 9
STIP1 stress-induced phosphoprotein 1
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SYPL1 synaptophysin-like 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAGLN2 transgelin 2
TLK2 tousled-like kinase 2
TMEM230 transmembrane protein 230
TSC2 tuberous sclerosis 2
TSKU tsukushi, small leucine rich proteoglycan
TSPAN4 tetraspanin 4
UBE2N ubiquitin-conjugating enzyme E2N
UBE4B ubiquitination factor E4B
UHRF1BP1L UHRF1 binding protein 1-like
USP34 ubiquitin specific peptidase 34
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF148 zinc finger protein 148
ZNF227 zinc finger protein 227

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
BATF3 basic leucine zipper transcription factor, ATF-like 3
BBC3 BCL2 binding component 3
C11ORF63 chromosome 11 open reading frame 63
C19ORF40 chromosome 19 open reading frame 40
C1QTNF3 C1q and tumor necrosis factor related protein 3
C9ORF114 chromosome 9 open reading frame 114
CDADC1 cytidine and dCMP deaminase domain containing 1
CHKB choline kinase beta
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLSPN claspin
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COBL cordon-bleu WH2 repeat protein
CST4 cystatin S
CXCR2 chemokine (C-X-C motif) receptor 2
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DMBT1 deleted in malignant brain tumors 1
DSPP dentin sialophosphoprotein
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCHO1 FCH domain only 1
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GRTP1 growth hormone regulated TBC protein 1
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H4C histone cluster 1, H4c
HOXC4 homeobox C4
HYI hydroxypyruvate isomerase (putative)
IGFLR1 IGF-like family receptor 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL37 interleukin 37
ITPKC inositol-trisphosphate 3-kinase C
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KLHL25 kelch-like family member 25
KPTN kaptin (actin binding protein)
LRRK1 leucine-rich repeat kinase 1
MBTD1 mbt domain containing 1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MILR1 mast cell immunoglobulin-like receptor 1
MMRN2 multimerin 2
MNX1 motor neuron and pancreas homeobox 1
MYO15A myosin XVA
NDE1 nudE neurodevelopment protein 1
NDP Norrie disease (pseudoglioma)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPAL2 NIPA-like domain containing 2
NOTCH4 notch 4
NPIPB15 nuclear pore complex interacting protein family, member B15
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARM1 prostate androgen-regulated mucin-like protein 1
PBLD phenazine biosynthesis-like protein domain containing
PCDH12 protocadherin 12
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE12 phosphodiesterase 12
PMCH pro-melanin-concentrating hormone
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PODNL1 podocan-like 1
POLL polymerase (DNA directed), lambda
PSG4 pregnancy specific beta-1-glycoprotein 4
RAB36 RAB36, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCD5 stearoyl-CoA desaturase 5
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SH2D2A SH2 domain containing 2A
SIRT2 sirtuin 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLITRK5 SLIT and NTRK-like family, member 5
SMR3A submaxillary gland androgen regulated protein 3A
SPRR2B small proline-rich protein 2B
SPTBN2 spectrin, beta, non-erythrocytic 2
STARD5 StAR-related lipid transfer (START) domain containing 5
STX17 syntaxin 17
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THAP7 THAP domain containing 7
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRAF2 TNF receptor-associated factor 2
UBQLN4 ubiquilin 4
UNC13A unc-13 homolog A (C. elegans)
XYLT2 xylosyltransferase II
ZBTB22 zinc finger and BTB domain containing 22
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF205 zinc finger protein 205
ZNF528 zinc finger protein 528
ZNF639 zinc finger protein 639
ZNF668 zinc finger protein 668