Glaucoma, Open-Angle Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

194 genes associated with the Glaucoma, Open-Angle phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
ADCY4 adenylate cyclase 4
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AFAP1 actin filament associated protein 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
ASB10 ankyrin repeat and SOCS box containing 10
ATOH7 atonal homolog 7 (Drosophila)
BCL2L2 BCL2-like 2
BMP4 bone morphogenetic protein 4
C12ORF56 chromosome 12 open reading frame 56
CARD10 caspase recruitment domain family, member 10
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CDC7 cell division cycle 7
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2B-AS1 CDKN2B antisense RNA 1
CHEK2 checkpoint kinase 2
CLU clusterin
CMA1 chymase 1, mast cell
CNTN4 contactin 4
CNTNAP4 contactin associated protein-like 4
COCH cochlin
COL8A1 collagen, type VIII, alpha 1
COL8A2 collagen, type VIII, alpha 2
COX3
CYBA cytochrome b-245, alpha polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DAD1 defender against cell death 1
DCLK1 doublecortin-like kinase 1
DMXL1 Dmx-like 1
DNM2 dynamin 2
DTWD2 DTW domain containing 2
EDN1 endothelin 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
ELOVL5 ELOVL fatty acid elongase 5
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FAR2 fatty acyl CoA reductase 2
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FKBP4 FK506 binding protein 4, 59kDa
FKBP5 FK506 binding protein 5
FNDC3B fibronectin type III domain containing 3B
FOXC1 forkhead box C1
FREM3 FRAS1 related extracellular matrix 3
GALC galactosylceramidase
GAS7 growth arrest-specific 7
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GLC1B glaucoma 1, open angle, B (adult-onset)
GLCCI1 glucocorticoid induced 1
GMDS GDP-mannose 4,6-dehydratase
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPX4 glutathione peroxidase 4
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HABP2 hyaluronan binding protein 2
HAP1 huntingtin-associated protein 1
HAS2 hyaluronan synthase 2
HFE hemochromatosis
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HSPA1A heat shock 70kDa protein 1A
HSPA1L heat shock 70kDa protein 1-like
HYAL3 hyaluronoglucosaminidase 3
ICA1 islet cell autoantigen 1, 69kDa
IGF2 insulin-like growth factor 2
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
IRF9 interferon regulatory factor 9
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LMX1B LIM homeobox transcription factor 1, beta
LOXL1 lysyl oxidase-like 1
LTBP2 latent transforming growth factor beta binding protein 2
LTBP3 latent transforming growth factor beta binding protein 3
MBL2 mannose-binding lectin (protein C) 2, soluble
MFAP2 microfibrillar-associated protein 2
MFN1 mitofusin 1
MFN2 mitofusin 2
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MT-ATP6 ATP synthase F0 subunit 6
MT-ND4 NADH dehydrogenase, subunit 4 (complex I)
MT-ND5 NADH dehydrogenase, subunit 5 (complex I)
MT-ND6 NADH dehydrogenase, subunit 6 (complex I)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUTYH mutY homolog
MYL9 myosin, light chain 9, regulatory
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
ND1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG2 neuregulin 2
NRL neural retina leucine zipper
NTF4 neurotrophin 4
NTM neurotrimin
OGG1 8-oxoguanine DNA glycosylase
OLFM2 olfactomedin 2
OPA1 optic atrophy 1 (autosomal dominant)
OPTC opticin
OPTN optineurin
OXA1L oxidase (cytochrome c) assembly 1-like
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PARL presenilin associated, rhomboid-like
PAX2 paired box 2
PHF12 PHD finger protein 12
PLXDC2 plexin domain containing 2
PMM2 phosphomannomutase 2
PON1 paraoxonase 1
PON2 paraoxonase 2
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PTGFR prostaglandin F receptor (FP)
RASSF3 Ras association (RalGDS/AF-6) domain family member 3
RDX radixin
REN renin
RERE arginine-glutamic acid dipeptide (RE) repeats
RFTN1 raftlin, lipid raft linker 1
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1
RPN2 ribophorin II
SALL1 spalt-like transcription factor 1
SALL2 spalt-like transcription factor 2
SCYL1 SCY1-like 1 (S. cerevisiae)
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIX1 SIX homeobox 1
SIX6 SIX homeobox 6
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNX16 sorting nexin 16
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRBD1 S1 RNA binding domain 1
SRSF3 serine/arginine-rich splicing factor 3
SRSF5 serine/arginine-rich splicing factor 5
SRSF9 serine/arginine-rich splicing factor 9
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBK1 TANK-binding kinase 1
TCEAL1 transcription elongation factor A (SII)-like 1
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR3 transforming growth factor, beta receptor III
TGM2 transglutaminase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TMCO1 transmembrane and coiled-coil domains 1
TMTC2 transmembrane and tetratricopeptide repeat containing 2
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TRPM5 transient receptor potential cation channel, subfamily M, member 5
TTPA tocopherol (alpha) transfer protein
TULP3 tubby like protein 3
VAMP5 vesicle-associated membrane protein 5
VAMP8 vesicle-associated membrane protein 8
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
WDR36 WD repeat domain 36
XPOT exportin, tRNA
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZNF219 zinc finger protein 219
ZNF469 zinc finger protein 469
ZP4 zona pellucida glycoprotein 4