GW-8510-7080 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the GW-8510-7080 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACACA acetyl-CoA carboxylase alpha
ADAM23 ADAM metallopeptidase domain 23
AK2 adenylate kinase 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMT aminomethyltransferase
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APC adenomatous polyposis coli
APLP1 amyloid beta (A4) precursor-like protein 1
APP amyloid beta (A4) precursor protein
AQP3 aquaporin 3 (Gill blood group)
ATF6B activating transcription factor 6 beta
ATXN2L ataxin 2-like
BMP5 bone morphogenetic protein 5
BMP7 bone morphogenetic protein 7
CASZ1 castor zinc finger 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD46 CD46 molecule, complement regulatory protein
CD59 CD59 molecule, complement regulatory protein
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CLCN7 chloride channel, voltage-sensitive 7
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DRD2 dopamine receptor D2
EFCAB2 EF-hand calcium binding domain 2
EGFL7 EGF-like-domain, multiple 7
EIF5A eukaryotic translation initiation factor 5A
ELF4 E74-like factor 4 (ets domain transcription factor)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FECH ferrochelatase
FUBP1 far upstream element (FUSE) binding protein 1
FUS FUS RNA binding protein
GALC galactosylceramidase
GLRX3 glutaredoxin 3
GOLIM4 golgi integral membrane protein 4
GPR137 G protein-coupled receptor 137
GPX1 glutathione peroxidase 1
GPX2 glutathione peroxidase 2
HABP4 hyaluronan binding protein 4
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H4D histone cluster 1, H4d
HSF2 heat shock transcription factor 2
HTT huntingtin
IER3 immediate early response 3
INF2 inverted formin, FH2 and WH2 domain containing
INPP5K inositol polyphosphate-5-phosphatase K
IRAK1 interleukin-1 receptor-associated kinase 1
IRF5 interferon regulatory factor 5
ITGB5 integrin, beta 5
KIAA0368 KIAA0368
LAD1 ladinin 1
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LMF2 lipase maturation factor 2
LMNA lamin A/C
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MOSPD3 motile sperm domain containing 3
MT1G metallothionein 1G
MYL5 myosin, light chain 5, regulatory
NADK NAD kinase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEB nebulin
NECAB3 N-terminal EF-hand calcium binding protein 3
NPM3 nucleophosmin/nucleoplasmin 3
PADI1 peptidyl arginine deiminase, type I
PCBP2 poly(rC) binding protein 2
PCGF2 polycomb group ring finger 2
PDLIM7 PDZ and LIM domain 7 (enigma)
PLA2G10 phospholipase A2, group X
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRAF2 PRA1 domain family, member 2
PTTG3P pituitary tumor-transforming 3, pseudogene
RAB2A RAB2A, member RAS oncogene family
RAD50 RAD50 homolog (S. cerevisiae)
RANGRF RAN guanine nucleotide release factor
RHOBTB3 Rho-related BTB domain containing 3
ROM1 retinal outer segment membrane protein 1
RPLP2 ribosomal protein, large, P2
RSL1D1 ribosomal L1 domain containing 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3BP2 SH3-domain binding protein 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
TFPI2 tissue factor pathway inhibitor 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TP53I11 tumor protein p53 inducible protein 11
TRIM14 tripartite motif containing 14
TRIM5 tripartite motif containing 5
UBE2G2 ubiquitin-conjugating enzyme E2G 2
URI1 URI1, prefoldin-like chaperone
WDTC1 WD and tetratricopeptide repeats 1
ZFR zinc finger RNA binding protein
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD49 ankyrin repeat domain 49
ARHGAP12 Rho GTPase activating protein 12
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4A ADP-ribosylation factor-like 4A
ARMCX5 armadillo repeat containing, X-linked 5
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BAMBI BMP and activin membrane-bound inhibitor
BLM Bloom syndrome, RecQ helicase-like
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C14ORF169 chromosome 14 open reading frame 169
C1ORF106 chromosome 1 open reading frame 106
C2ORF42 chromosome 2 open reading frame 42
CASP8AP2 caspase 8 associated protein 2
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDT1 chromatin licensing and DNA replication factor 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPE centromere protein E, 312kDa
CHD1 chromodomain helicase DNA binding protein 1
CSRNP2 cysteine-serine-rich nuclear protein 2
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOLK dolichol kinase
E2F6 E2F transcription factor 6
EFNA1 ephrin-A1
EGR3 early growth response 3
ERCC6L excision repair cross-complementation group 6-like
FADD Fas (TNFRSF6)-associated via death domain
FAM50B family with sequence similarity 50, member B
FAM53C family with sequence similarity 53, member C
FANCF Fanconi anemia, complementation group F
FBXL14 F-box and leucine-rich repeat protein 14
FBXO34 F-box protein 34
FBXO5 F-box protein 5
FOXD1 forkhead box D1
FOXK2 forkhead box K2
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HILPDA hypoxia inducible lipid droplet-associated
HJURP Holliday junction recognition protein
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
JMJD1C jumonji domain containing 1C
KIAA0922 KIAA0922
KRCC1 lysine-rich coiled-coil 1
LOC100272216 uncharacterized LOC100272216
MED7 mediator complex subunit 7
METTL18 methyltransferase like 18
MGA MGA, MAX dimerization protein
MKL2 MKL/myocardin-like 2
NDC80 NDC80 kinetochore complex component
NPY1R neuropeptide Y receptor Y1
OSR2 odd-skipped related transciption factor 2
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PALB2 partner and localizer of BRCA2
PCF11 PCF11 cleavage and polyadenylation factor subunit
PLK2 polo-like kinase 2
PNRC1 proline-rich nuclear receptor coactivator 1
PNRC2 proline-rich nuclear receptor coactivator 2
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRR15L proline rich 15-like
PTCD1 pentatricopeptide repeat domain 1
RANBP6 RAN binding protein 6
RBM7 RNA binding motif protein 7
RIOK2 RIO kinase 2
RNF113A ring finger protein 113A
RNMTL1 RNA methyltransferase like 1
RPP38 ribonuclease P/MRP 38kDa subunit
SALL2 spalt-like transcription factor 2
SIRT1 sirtuin 1
SLC38A2 solute carrier family 38, member 2
SMG8 SMG8 nonsense mediated mRNA decay factor
SPATA2L spermatogenesis associated 2-like
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBCC tubulin folding cofactor C
TBK1 TANK-binding kinase 1
TGIF1 TGFB-induced factor homeobox 1
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIM32 tripartite motif containing 32
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TROAP trophinin associated protein
TRPS1 trichorhinophalangeal syndrome I
TSPYL5 TSPY-like 5
TTK TTK protein kinase
URGCP upregulator of cell proliferation
VANGL1 VANGL planar cell polarity protein 1
ZBED5 zinc finger, BED-type containing 5
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC8 zinc finger, CCHC domain containing 8
ZHX2 zinc fingers and homeoboxes 2
ZNF217 zinc finger protein 217
ZNF232 zinc finger protein 232
ZNF443 zinc finger protein 443
ZNF629 zinc finger protein 629
ZNF84 zinc finger protein 84
ZSCAN16 zinc finger and SCAN domain containing 16