GW-8510-7067 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the GW-8510-7067 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APLP1 amyloid beta (A4) precursor-like protein 1
APP amyloid beta (A4) precursor protein
ARC activity-regulated cytoskeleton-associated protein
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ASIC1 acid sensing (proton gated) ion channel 1
B9D1 B9 protein domain 1
BLZF1 basic leucine zipper nuclear factor 1
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CCNT2 cyclin T2
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLDN1 claudin 1
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
EML3 echinoderm microtubule associated protein like 3
ERCC1 excision repair cross-complementation group 1
FAXDC2 fatty acid hydroxylase domain containing 2
FCMR Fc fragment of IgM receptor
FER1L4 fer-1-like family member 4, pseudogene (functional)
FH fumarate hydratase
FOS FBJ murine osteosarcoma viral oncogene homolog
FUBP1 far upstream element (FUSE) binding protein 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GADD45B growth arrest and DNA-damage-inducible, beta
GTPBP4 GTP binding protein 4
HIST1H2AE histone cluster 1, H2ae
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB2 homeobox B2
IL6 interleukin 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0368 KIAA0368
KLF2 Kruppel-like factor 2
KRIT1 KRIT1, ankyrin repeat containing
KRT4 keratin 4, type II
LIMK1 LIM domain kinase 1
LOC157562 uncharacterized LOC157562
LPP LIM domain containing preferred translocation partner in lipoma
MAOA monoamine oxidase A
MAPK3 mitogen-activated protein kinase 3
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MED6 mediator complex subunit 6
METTL5 methyltransferase like 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCF4 neutrophil cytosolic factor 4, 40kDa
NCS1 neuronal calcium sensor 1
NGDN neuroguidin, EIF4E binding protein
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODF2 outer dense fiber of sperm tails 2
PAQR6 progestin and adipoQ receptor family member VI
PARVB parvin, beta
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLXNA3 plexin A3
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QKI QKI, KH domain containing, RNA binding
RBM3 RNA binding motif (RNP1, RRM) protein 3
RHOB ras homolog family member B
RNF126P1 ring finger protein 126 pseudogene 1
RPL14 ribosomal protein L14
RPS9 ribosomal protein S9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SCML2 sex comb on midleg-like 2 (Drosophila)
SEC63 SEC63 homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIK1 salt-inducible kinase 1
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SNORA21 small nucleolar RNA, H/ACA box 21
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAGLN3 transgelin 3
TCP11L1 t-complex 11, testis-specific-like 1
TCTN1 tectonic family member 1
TCTN2 tectonic family member 2
TGFB2 transforming growth factor, beta 2
TH tyrosine hydroxylase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM2 tropomyosin 2 (beta)
TTC12 tetratricopeptide repeat domain 12
URI1 URI1, prefoldin-like chaperone
VIPR2 vasoactive intestinal peptide receptor 2

decreased expression

Symbol Name
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANKRD49 ankyrin repeat domain 49
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4A ADP-ribosylation factor-like 4A
BAG3 BCL2-associated athanogene 3
BCAR3 breast cancer anti-estrogen resistance 3
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF169 chromosome 14 open reading frame 169
C1ORF106 chromosome 1 open reading frame 106
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDKN2AIP CDKN2A interacting protein
CHD1 chromodomain helicase DNA binding protein 1
CHD8 chromodomain helicase DNA binding protein 8
CLK4 CDC-like kinase 4
CLP1 cleavage and polyadenylation factor I subunit 1
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTCF CCCTC-binding factor (zinc finger protein)
DBF4 DBF4 zinc finger
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPF2 D4, zinc and double PHD fingers family 2
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
DUSP6 dual specificity phosphatase 6
E2F6 E2F transcription factor 6
E2F8 E2F transcription factor 8
ERCC6L excision repair cross-complementation group 6-like
FADD Fas (TNFRSF6)-associated via death domain
FBXO34 F-box protein 34
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FZD8 frizzled class receptor 8
GCC1 GRIP and coiled-coil domain containing 1
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPR87 G protein-coupled receptor 87
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
GUSBP3 glucuronidase, beta pseudogene 3
HAS2 hyaluronan synthase 2
HAUS3 HAUS augmin-like complex, subunit 3
HILPDA hypoxia inducible lipid droplet-associated
HJURP Holliday junction recognition protein
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS1 insulin receptor substrate 1
JMJD1C jumonji domain containing 1C
KEAP1 kelch-like ECH-associated protein 1
KIF23 kinesin family member 23
KLHL21 kelch-like family member 21
LEMD3 LEM domain containing 3
LIPT1 lipoyltransferase 1
LOC100272216 uncharacterized LOC100272216
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MED7 mediator complex subunit 7
MFSD5 major facilitator superfamily domain containing 5
MGA MGA, MAX dimerization protein
NDC80 NDC80 kinetochore complex component
NFE2L2 nuclear factor, erythroid 2-like 2
NRBF2 nuclear receptor binding factor 2
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PEX11B peroxisomal biogenesis factor 11 beta
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PNRC2 proline-rich nuclear receptor coactivator 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PTRH2 peptidyl-tRNA hydrolase 2
RANBP6 RAN binding protein 6
RBM7 RNA binding motif protein 7
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNF111 ring finger protein 111
RNF113A ring finger protein 113A
RNMTL1 RNA methyltransferase like 1
RSBN1 round spermatid basic protein 1
SCO2 SCO2 cytochrome c oxidase assembly protein
SIRT1 sirtuin 1
SIRT7 sirtuin 7
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX9 SRY (sex determining region Y)-box 9
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBCC tubulin folding cofactor C
TEFM transcription elongation factor, mitochondrial
THAP11 THAP domain containing 11
TOB1 transducer of ERBB2, 1
TRIB3 tribbles pseudokinase 3
TRIM13 tripartite motif containing 13
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TSPYL5 TSPY-like 5
TTK TTK protein kinase
XBP1 X-box binding protein 1
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZBED5 zinc finger, BED-type containing 5
ZC3H4 zinc finger CCCH-type containing 4
ZNF217 zinc finger protein 217
ZNF248 zinc finger protein 248
ZNF443 zinc finger protein 443
ZNF7 zinc finger protein 7