GW-8510-7062 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the GW-8510-7062 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADRBK1 adrenergic, beta, receptor kinase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASB9 ankyrin repeat and SOCS box containing 9
ATP11A ATPase, class VI, type 11A
B9D1 B9 protein domain 1
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
CA4 carbonic anhydrase IV
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCDC88C coiled-coil domain containing 88C
CD320 CD320 molecule
CLCN7 chloride channel, voltage-sensitive 7
COL5A1 collagen, type V, alpha 1
COL6A1 collagen, type VI, alpha 1
COMT catechol-O-methyltransferase
CSF1 colony stimulating factor 1 (macrophage)
CST6 cystatin E/M
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DIO2 deiodinase, iodothyronine, type II
ERAP1 endoplasmic reticulum aminopeptidase 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FER1L4 fer-1-like family member 4, pseudogene (functional)
FSCN1 fascin actin-bundling protein 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLB1L galactosidase, beta 1-like
GM2A GM2 ganglioside activator
GPC1 glypican 1
GPX1 glutathione peroxidase 1
HBS1L HBS1-like translational GTPase
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIST1H2AM histone cluster 1, H2am
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IER3 immediate early response 3
IQSEC2 IQ motif and Sec7 domain 2
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KIAA0368 KIAA0368
KIF1A kinesin family member 1A
KLF6 Kruppel-like factor 6
LAMP1 lysosomal-associated membrane protein 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYRM9 LYR motif containing 9
MAPK11 mitogen-activated protein kinase 11
MCFD2 multiple coagulation factor deficiency 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP25 matrix metallopeptidase 25
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
NF1 neurofibromin 1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OLFML3 olfactomedin-like 3
PARVA parvin, alpha
PDLIM5 PDZ and LIM domain 5
PDLIM7 PDZ and LIM domain 7 (enigma)
PODNL1 podocan-like 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PSG1 pregnancy specific beta-1-glycoprotein 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae)
RPL23 ribosomal protein L23
RPL23AP32 ribosomal protein L23a pseudogene 32
RPLP2 ribosomal protein, large, P2
RPS28 ribosomal protein S28
RSL1D1 ribosomal L1 domain containing 1
S100A11 S100 calcium binding protein A11
S100A6 S100 calcium binding protein A6
SBNO1 strawberry notch homolog 1 (Drosophila)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SRPX sushi-repeat containing protein, X-linked
SSX3 synovial sarcoma, X breakpoint 3
SYMPK symplekin
TCF3 transcription factor 3
TFF3 trefoil factor 3 (intestinal)
TH tyrosine hydroxylase
TLN2 talin 2
TM7SF3 transmembrane 7 superfamily member 3
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TP53I11 tumor protein p53 inducible protein 11
TPSG1 tryptase gamma 1
TUBA3D tubulin, alpha 3d
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEGFB vascular endothelial growth factor B
WDTC1 WD and tetratricopeptide repeats 1
WWOX WW domain containing oxidoreductase
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD49 ankyrin repeat domain 49
ARHGAP12 Rho GTPase activating protein 12
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX5 armadillo repeat containing, X-linked 5
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAMBI BMP and activin membrane-bound inhibitor
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C11ORF57 chromosome 11 open reading frame 57
C14ORF169 chromosome 14 open reading frame 169
C7ORF49 chromosome 7 open reading frame 49
CASP8AP2 caspase 8 associated protein 2
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPE centromere protein E, 312kDa
CHD1 chromodomain helicase DNA binding protein 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLK1 CDC-like kinase 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DCLRE1B DNA cross-link repair 1B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOLK dolichol kinase
E2F6 E2F transcription factor 6
EFNA1 ephrin-A1
EFNA4 ephrin-A4
EGR3 early growth response 3
ERCC6L excision repair cross-complementation group 6-like
FADD Fas (TNFRSF6)-associated via death domain
FANCF Fanconi anemia, complementation group F
FBXO5 F-box protein 5
FEM1C fem-1 homolog c (C. elegans)
FOXD1 forkhead box D1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GCC1 GRIP and coiled-coil domain containing 1
GPATCH1 G patch domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HJURP Holliday junction recognition protein
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ING3 inhibitor of growth family, member 3
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
JMJD1C jumonji domain containing 1C
KIAA0922 KIAA0922
KIAA1551 KIAA1551
KIF16B kinesin family member 16B
KIF20B kinesin family member 20B
KRCC1 lysine-rich coiled-coil 1
LEMD3 LEM domain containing 3
LRIF1 ligand dependent nuclear receptor interacting factor 1
METTL18 methyltransferase like 18
MGA MGA, MAX dimerization protein
MKL2 MKL/myocardin-like 2
MSL2 male-specific lethal 2 homolog (Drosophila)
NDC80 NDC80 kinetochore complex component
NPY1R neuropeptide Y receptor Y1
PALB2 partner and localizer of BRCA2
PLK2 polo-like kinase 2
PNRC1 proline-rich nuclear receptor coactivator 1
PNRC2 proline-rich nuclear receptor coactivator 2
PPAN peter pan homolog (Drosophila)
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRR15L proline rich 15-like
RANBP6 RAN binding protein 6
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RNMTL1 RNA methyltransferase like 1
RPP38 ribonuclease P/MRP 38kDa subunit
SLC38A2 solute carrier family 38, member 2
SMG8 SMG8 nonsense mediated mRNA decay factor
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBCC tubulin folding cofactor C
TGIF1 TGFB-induced factor homeobox 1
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRIB1 tribbles pseudokinase 1
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
VANGL1 VANGL planar cell polarity protein 1
WDR5B WD repeat domain 5B
XBP1 X-box binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZBTB10 zinc finger and BTB domain containing 10
ZBTB3 zinc finger and BTB domain containing 3
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC10 zinc finger, CCHC domain containing 10
ZCCHC8 zinc finger, CCHC domain containing 8
ZIC1 Zic family member 1
ZNF107 zinc finger protein 107
ZNF146 zinc finger protein 146
ZNF217 zinc finger protein 217
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF443 zinc finger protein 443