GPCR ligand binding Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-500792
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Genes

440 proteins participating in the GPCR ligand binding pathway from the Reactome Pathways dataset.

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR2 atypical chemokine receptor 2
ACKR3 atypical chemokine receptor 3
ACKR4 atypical chemokine receptor 4
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADGRE1 adhesion G protein-coupled receptor E1
ADGRE2 adhesion G protein-coupled receptor E2
ADGRE3 adhesion G protein-coupled receptor E3
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
ADM2 adrenomedullin 2
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
ANXA1 annexin A1
APLN apelin
APLNR apelin receptor
APP amyloid beta (A4) precursor protein
AVP arginine vasopressin
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
AVPR2 arginine vasopressin receptor 2
BDKRB1 bradykinin receptor B1
BDKRB2 bradykinin receptor B2
BRS3 bombesin-like receptor 3
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5 complement component 5
C5AR1 complement component 5a receptor 1
C5AR2 complement component 5a receptor 2
CALCA calcitonin-related polypeptide alpha
CALCB calcitonin-related polypeptide beta
CALCR calcitonin receptor
CALCRL calcitonin receptor-like
CASR calcium-sensing receptor
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CCL11 chemokine (C-C motif) ligand 11
CCL16 chemokine (C-C motif) ligand 16
CCL17 chemokine (C-C motif) ligand 17
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL21 chemokine (C-C motif) ligand 21
CCL22 chemokine (C-C motif) ligand 22
CCL23 chemokine (C-C motif) ligand 23
CCL25 chemokine (C-C motif) ligand 25
CCL27 chemokine (C-C motif) ligand 27
CCL28 chemokine (C-C motif) ligand 28
CCL3 chemokine (C-C motif) ligand 3
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCL7 chemokine (C-C motif) ligand 7
CCR1 chemokine (C-C motif) receptor 1
CCR10 chemokine (C-C motif) receptor 10
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCR8 chemokine (C-C motif) receptor 8
CCR9 chemokine (C-C motif) receptor 9
CCRL2 chemokine (C-C motif) receptor-like 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CGA glycoprotein hormones, alpha polypeptide
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CXCR6 chemokine (C-X-C motif) receptor 6
CYSLTR1 cysteinyl leukotriene receptor 1
CYSLTR2 cysteinyl leukotriene receptor 2
DHH desert hedgehog
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
EDN1 endothelin 1
EDN2 endothelin 2
EDN3 endothelin 3
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F2RL2 coagulation factor II (thrombin) receptor-like 2
F2RL3 coagulation factor II (thrombin) receptor-like 3
FFAR1 free fatty acid receptor 1
FFAR2 free fatty acid receptor 2
FFAR3 free fatty acid receptor 3
FFAR4 free fatty acid receptor 4
FPR1 formyl peptide receptor 1
FPR2 formyl peptide receptor 2
FPR3 formyl peptide receptor 3
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
FZD1 frizzled class receptor 1
FZD10 frizzled class receptor 10
FZD2 frizzled class receptor 2
FZD3 frizzled class receptor 3
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
FZD9 frizzled class receptor 9
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAL galanin/GMAP prepropeptide
GALR1 galanin receptor 1
GALR2 galanin receptor 2
GALR3 galanin receptor 3
GCG glucagon
GCGR glucagon receptor
GHRH growth hormone releasing hormone
GHRHR growth hormone releasing hormone receptor
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GIP gastric inhibitory polypeptide
GIPR gastric inhibitory polypeptide receptor
GLP1R glucagon-like peptide 1 receptor
GLP2R glucagon-like peptide 2 receptor
GNAS GNAS complex locus
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNG8 guanine nucleotide binding protein (G protein), gamma 8
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRH2 gonadotropin-releasing hormone 2
GNRHR gonadotropin-releasing hormone receptor
GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2, pseudogene
GPBAR1 G protein-coupled bile acid receptor 1
GPER1 G protein-coupled estrogen receptor 1
GPR132 G protein-coupled receptor 132
GPR17 G protein-coupled receptor 17
GPR18 G protein-coupled receptor 18
GPR31 G protein-coupled receptor 31
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPR37L1 G protein-coupled receptor 37 like 1
GPR39 G protein-coupled receptor 39
GPR4 G protein-coupled receptor 4
GPR55 G protein-coupled receptor 55
GPR65 G protein-coupled receptor 65
GPR68 G protein-coupled receptor 68
GPRC6A G protein-coupled receptor, class C, group 6, member A
GRM1 glutamate receptor, metabotropic 1
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
GRM4 glutamate receptor, metabotropic 4
GRM5 glutamate receptor, metabotropic 5
GRM6 glutamate receptor, metabotropic 6
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
GRP gastrin-releasing peptide
GRPR gastrin-releasing peptide receptor
HCAR1 hydroxycarboxylic acid receptor 1
HCAR2 hydroxycarboxylic acid receptor 2
HCAR3 hydroxycarboxylic acid receptor 3
HCRT hypocretin (orexin) neuropeptide precursor
HCRTR1 hypocretin (orexin) receptor 1
HCRTR2 hypocretin (orexin) receptor 2
HEBP1 heme binding protein 1
HRH1 histamine receptor H1
HRH2 histamine receptor H2
HRH3 histamine receptor H3
HRH4 histamine receptor H4
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IAPP islet amyloid polypeptide
IHH indian hedgehog
INSL3 insulin-like 3 (Leydig cell)
INSL5 insulin-like 5
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
KNG1 kininogen 1
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
LPAR1 lysophosphatidic acid receptor 1
LPAR2 lysophosphatidic acid receptor 2
LPAR3 lysophosphatidic acid receptor 3
LPAR4 lysophosphatidic acid receptor 4
LPAR5 lysophosphatidic acid receptor 5
LPAR6 lysophosphatidic acid receptor 6
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MC5R melanocortin 5 receptor
MCHR1 melanin-concentrating hormone receptor 1
MCHR2 melanin-concentrating hormone receptor 2
MLN motilin
MLNR motilin receptor
MTNR1A melatonin receptor 1A
MTNR1B melatonin receptor 1B
NMB neuromedin B
NMBR neuromedin B receptor
NMS neuromedin S
NMU neuromedin U
NMUR1 neuromedin U receptor 1
NMUR2 neuromedin U receptor 2
NPB neuropeptide B
NPBWR1 neuropeptides B/W receptor 1
NPBWR2 neuropeptides B/W receptor 2
NPFF neuropeptide FF-amide peptide precursor
NPFFR1 neuropeptide FF receptor 1
NPFFR2 neuropeptide FF receptor 2
NPS neuropeptide S
NPSR1 neuropeptide S receptor 1
NPW neuropeptide W
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY4R neuropeptide Y receptor Y4
NPY5R neuropeptide Y receptor Y5
NTS neurotensin
NTSR1 neurotensin receptor 1 (high affinity)
NTSR2 neurotensin receptor 2
OPN1LW opsin 1 (cone pigments), long-wave-sensitive
OPN1MW opsin 1 (cone pigments), medium-wave-sensitive
OPN1SW opsin 1 (cone pigments), short-wave-sensitive
OPN3 opsin 3
OPN4 opsin 4
OPN5 opsin 5
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
OXER1 oxoeicosanoid (OXE) receptor 1
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY10 purinergic receptor P2Y, G-protein coupled, 10
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDYN prodynorphin
PENK proenkephalin
PF4 platelet factor 4
PMCH pro-melanin-concentrating hormone
PNOC prepronociceptin
POMC proopiomelanocortin
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPY pancreatic polypeptide
PRLH prolactin releasing hormone
PRLHR prolactin releasing hormone receptor
PROK1 prokineticin 1
PROK2 prokineticin 2
PROKR1 prokineticin receptor 1
PROKR2 prokineticin receptor 2
PSAP prosaposin
PTAFR platelet-activating factor receptor
PTCH1 patched 1
PTCH2 patched 2
PTGDR prostaglandin D2 receptor (DP)
PTGDR2 prostaglandin D2 receptor 2
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGFR prostaglandin F receptor (FP)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTH parathyroid hormone
PTH1R parathyroid hormone 1 receptor
PTH2 parathyroid hormone 2
PTH2R parathyroid hormone 2 receptor
PTHLH parathyroid hormone-like hormone
PYY peptide YY
QRFP pyroglutamylated RFamide peptide
QRFPR pyroglutamylated RFamide peptide receptor
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RGR retinal G protein coupled receptor
RHO rhodopsin
RLN2 relaxin 2
RLN3 relaxin 3
RRH retinal pigment epithelium-derived rhodopsin homolog
RXFP1 relaxin/insulin-like family peptide receptor 1
RXFP2 relaxin/insulin-like family peptide receptor 2
RXFP3 relaxin/insulin-like family peptide receptor 3
RXFP4 relaxin/insulin-like family peptide receptor 4
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
S1PR3 sphingosine-1-phosphate receptor 3
S1PR4 sphingosine-1-phosphate receptor 4
S1PR5 sphingosine-1-phosphate receptor 5
SAA1 serum amyloid A1
SCT secretin
SCTR secretin receptor
SHH sonic hedgehog
SMO smoothened, frizzled class receptor
SST somatostatin
SSTR1 somatostatin receptor 1
SSTR2 somatostatin receptor 2
SSTR3 somatostatin receptor 3
SSTR4 somatostatin receptor 4
SSTR5 somatostatin receptor 5
SUCNR1 succinate receptor 1
TAAR1 trace amine associated receptor 1
TAAR2 trace amine associated receptor 2
TAAR3 trace amine associated receptor 3 (gene/pseudogene)
TAAR5 trace amine associated receptor 5
TAAR6 trace amine associated receptor 6
TAAR8 trace amine associated receptor 8
TAAR9 trace amine associated receptor 9 (gene/pseudogene)
TAC1 tachykinin, precursor 1
TAC3 tachykinin 3
TACR1 tachykinin receptor 1
TACR2 tachykinin receptor 2
TACR3 tachykinin receptor 3
TAS1R1 taste receptor, type 1, member 1
TAS1R2 taste receptor, type 1, member 2
TAS1R3 taste receptor, type 1, member 3
TAS2R1 taste receptor, type 2, member 1
TAS2R10 taste receptor, type 2, member 10
TAS2R13 taste receptor, type 2, member 13
TAS2R14 taste receptor, type 2, member 14
TAS2R16 taste receptor, type 2, member 16
TAS2R19 taste receptor, type 2, member 19
TAS2R20 taste receptor, type 2, member 20
TAS2R3 taste receptor, type 2, member 3
TAS2R30 taste receptor, type 2, member 30
TAS2R31 taste receptor, type 2, member 31
TAS2R38 taste receptor, type 2, member 38
TAS2R39 taste receptor, type 2, member 39
TAS2R4 taste receptor, type 2, member 4
TAS2R40 taste receptor, type 2, member 40
TAS2R41 taste receptor, type 2, member 41
TAS2R42 taste receptor, type 2, member 42
TAS2R43 taste receptor, type 2, member 43
TAS2R45 taste receptor, type 2, member 45
TAS2R46 taste receptor, type 2, member 46
TAS2R5 taste receptor, type 2, member 5
TAS2R50 taste receptor, type 2, member 50
TAS2R60 taste receptor, type 2, member 60
TAS2R7 taste receptor, type 2, member 7
TAS2R8 taste receptor, type 2, member 8
TAS2R9 taste receptor, type 2, member 9
TBXA2R thromboxane A2 receptor
TRH thyrotropin-releasing hormone
TRHR thyrotropin-releasing hormone receptor
TSHB thyroid stimulating hormone, beta
TSHR thyroid stimulating hormone receptor
UTS2 urotensin 2
UTS2B urotensin 2B
UTS2R urotensin 2 receptor
WNT1 wingless-type MMTV integration site family, member 1
WNT10A wingless-type MMTV integration site family, member 10A
WNT10B wingless-type MMTV integration site family, member 10B
WNT11 wingless-type MMTV integration site family, member 11
WNT16 wingless-type MMTV integration site family, member 16
WNT2 wingless-type MMTV integration site family member 2
WNT2B wingless-type MMTV integration site family, member 2B
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WNT6 wingless-type MMTV integration site family, member 6
WNT7A wingless-type MMTV integration site family, member 7A
WNT7B wingless-type MMTV integration site family, member 7B
WNT8A wingless-type MMTV integration site family, member 8A
WNT8B wingless-type MMTV integration site family, member 8B
WNT9A wingless-type MMTV integration site family, member 9A
WNT9B wingless-type MMTV integration site family, member 9B
XCL1 chemokine (C motif) ligand 1
XCL2 chemokine (C motif) ligand 2
XCR1 chemokine (C motif) receptor 1