Fetal Membranes, Premature Rupture Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

199 genes associated with the Fetal Membranes, Premature Rupture phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPT2 angiopoietin 2
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
AQP2 aquaporin 2 (collecting duct)
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CD14 CD14 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CETP cholesteryl ester transfer protein, plasma
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFB1 defensin, beta 1
DLAT dihydrolipoamide S-acetyltransferase
EDN1 endothelin 1
ELN elastin
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F12 coagulation factor XII (Hageman factor)
F13A1 coagulation factor XIII, A1 polypeptide
F13B coagulation factor XIII, B polypeptide
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FABP2 fatty acid binding protein 2, intestinal
FAS Fas cell surface death receptor
FGB fibrinogen beta chain
FGF1 fibroblast growth factor 1 (acidic)
FGF2 fibroblast growth factor 2 (basic)
FGF4 fibroblast growth factor 4
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
GJA4 gap junction protein, alpha 4, 37kDa
GJB2 gap junction protein, beta 2, 26kDa
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA4 heat shock 70kDa protein 4
HSPG2 heparan sulfate proteoglycan 2
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13RA2 interleukin 13 receptor, alpha 2
IL18 interleukin 18
IL18BP interleukin 18 binding protein
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL3 interleukin 3
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
IL9 interleukin 9
IL9R interleukin 9 receptor
IRS1 insulin receptor substrate 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
LEP leptin
LIPC lipase, hepatic
LOXL1 lysyl oxidase-like 1
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LTA lymphotoxin alpha
LTF lactotransferrin
LYZ lysozyme
MBL2 mannose-binding lectin (protein C) 2, soluble
MGP matrix Gla protein
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP11 matrix metallopeptidase 11
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP19 matrix metallopeptidase 19
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
NPY neuropeptide Y
OXTR oxytocin receptor
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PECAM1 platelet/endothelial cell adhesion molecule 1
PGF placental growth factor
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROS1 protein S (alpha)
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAN RAN, member RAS oncogene family
REN renin
RLN2 relaxin 2
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPC surfactant protein C
SOD3 superoxide dismutase 3, extracellular
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBXAS1 thromboxane A synthase 1 (platelet)
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
THBS1 thrombospondin 1
THBS4 thrombospondin 4
THPO thrombopoietin
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNR tenascin R
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VEGFC vascular endothelial growth factor C
VWF von Willebrand factor