Essential Tremor Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms. (Human Disease Ontology, DOID_4990)
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Genes

33 genes associated with the Essential Tremor phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALAD aminolevulinate dehydratase
APOB apolipoprotein B
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DRD3 dopamine receptor D3
ETM2 essential tremor 2
FMR1 fragile X mental retardation 1
FRAXA fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)
FUS FUS RNA binding protein
GABARAP GABA(A) receptor-associated protein
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GBA glucosidase, beta, acid
GSTP1 glutathione S-transferase pi 1
HNMT histamine N-methyltransferase
LINGO1 leucine rich repeat and Ig domain containing 1
LINGO2 leucine rich repeat and Ig domain containing 2
LINGO4 leucine rich repeat and Ig domain containing 4
LRRK2 leucine-rich repeat kinase 2
MAPT microtubule-associated protein tau
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
PARK2 parkin RBR E3 ubiquitin protein ligase
PON1 paraoxonase 1
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
USP9Y ubiquitin specific peptidase 9, Y-linked