Esophageal Squamous Cell Carcinoma Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A squamous cell carcinoma arising from the esophagus. It is associated with a long history of tobacco and alcohol abuse and is exceedingly rare before the age of 30. The median age is around 65 in both males and females. It is located mostly in the middle and lower third of the esophagus. Grossly, polypoid, ulcerated, plaque-like and occult lesions have been described. The microscopic features are the same as in other squamous cell carcinomas. Any degree of differentiation may occur, and variation within a single tumor is common. The prognosis is poor. (Experimental Factor Ontology, EFO_0005922)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:C562729
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Genes

79 genes/proteins associated with the disease Esophageal Squamous Cell Carcinoma from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 2.88009
KDM6A lysine (K)-specific demethylase 6A 2.88009
CA1 carbonic anhydrase I 2.88009
SLC39A6 solute carrier family 39 (zinc transporter), member 6 2.88009
HIST1H2BM histone cluster 1, H2bm 2.88009
CA2 carbonic anhydrase II 2.88009
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.88009
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.88009
TPM1 tropomyosin 1 (alpha) 2.88009
TPM2 tropomyosin 2 (beta) 2.88009
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 2.88009
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 2.88009
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.88009
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 2.88009
TXNDC17 thioredoxin domain containing 17 2.88009
TP53 tumor protein p53 2.88009
FAT4 FAT atypical cadherin 4 2.88009
PLCE1 phospholipase C, epsilon 1 2.88009
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.88009
EP300 E1A binding protein p300 2.88009
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.88009
CREBBP CREB binding protein 2.88009
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.88009
CCND1 cyclin D1 2.88009
GSTT1 glutathione S-transferase theta 1 2.88009
CDKN2A cyclin-dependent kinase inhibitor 2A 2.88009
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 2.88009
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.88009
CFL1 cofilin 1 (non-muscle) 2.88009
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.88009
SOX2 SRY (sex determining region Y)-box 2 2.88009
NFE2L2 nuclear factor, erythroid 2-like 2 2.88009
KMT2D lysine (K)-specific methyltransferase 2D 2.88009
AJUBA ajuba LIM protein 2.88009
EGFR epidermal growth factor receptor 2.88009
TMEM173 transmembrane protein 173 2.88009
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.88009
KMT2C lysine (K)-specific methyltransferase 2C 2.88009
CSTB cystatin B (stefin B) 2.88009
PRDX1 peroxiredoxin 1 2.88009
PFN1 profilin 1 2.88009
GLO1 glyoxalase I 2.88009
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.88009
TPI1 triosephosphate isomerase 1 2.88009
TYMP thymidine phosphorylase 2.88009
FAT1 FAT atypical cadherin 1 2.88009
FAT2 FAT atypical cadherin 2 2.88009
FAT3 FAT atypical cadherin 3 2.88009
CALR calreticulin 2.88009
NOTCH3 notch 3 2.88009
NOTCH2 notch 2 2.88009
NOTCH1 notch 1 2.88009
GDI2 GDP dissociation inhibitor 2 2.88009
CRABP1 cellular retinoic acid binding protein 1 2.88009
WWOX WW domain containing oxidoreductase 2.88009
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.88009
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 2.88009
FKBP1A FK506 binding protein 1A, 12kDa 2.88009
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.88009
SOD2 superoxide dismutase 2, mitochondrial 2.88009
MIR217 microRNA 217 2.88009
ANXA1 annexin A1 2.88009
HMGB1 high mobility group box 1 2.88009
GSTO1 glutathione S-transferase omega 1 2.88009
MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 2.88009
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.88009
BLVRB biliverdin reductase B 2.88009
SFN stratifin 2.88009
KRT19 keratin 19, type I 2.88009
KRT13 keratin 13, type I 2.88009
KRT14 keratin 14, type I 2.88009
KRT17 keratin 17, type I 2.88009
MIR423 microRNA 423 2.88009
CLIC1 chloride intracellular channel 1 2.88009
B2M beta-2-microglobulin 2.88009
RB1 retinoblastoma 1 2.88009
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.88009
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 2.88009
TAGLN transgelin 2.88009