EPO signaling pathway Gene Set

Dataset PID Pathways
Category structural or functional annotations
Type pathway
Description Erythropoietin (EPO) signaling is crucial for the production of blood cell or erythropoiesis and also plays important roles in wound healing and responses to neural injury. EPO is a glycoprotein hormone and also a cytokine whose receptor belongs to type I cytokine receptor. The pathway engages the Jak-Stat intracellular cascade. (Pathway Ontology, PW_0000987)
External Link http://public.ndexbio.org/#/network/20fe3c0e-6192-11e5-8ac5-06603eb7f303
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Genes

33 proteins participating in the EPO signaling pathway pathway from the PID Pathways dataset.

Symbol Name
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BTK Bruton agammaglobulinemia tyrosine kinase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
EPO erythropoietin
EPOR erythropoietin receptor
GAB1 GRB2-associated binding protein 1
GRB2 growth factor receptor-bound protein 2
HRAS Harvey rat sarcoma viral oncogene homolog
IRS2 insulin receptor substrate 2
JAK2 Janus kinase 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAP1A RAP1A, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
SH2B3 SH2B adaptor protein 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TEC tec protein tyrosine kinase
TRPC6 transient receptor potential cation channel, subfamily C, member 6
VAV2 vav 2 guanine nucleotide exchange factor