EGFR Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description epidermal growth factor receptor|The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 1956)
External Link http://www.ncbi.nlm.nih.gov/gene/1956
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Genes

35 substrates of the kinase EGFR from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AGO2 argonaute RISC catalytic component 2
ANXA1 annexin A1
ARHGAP35 Rho GTPase activating protein 35
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATM ATM serine/threonine kinase
BECN1 beclin 1, autophagy related
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC50 coiled-coil domain containing 50
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
EGFR epidermal growth factor receptor
EPB41 erythrocyte membrane protein band 4.1
EPS15 epidermal growth factor receptor pathway substrate 15
EZR ezrin
GAB1 GRB2-associated binding protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTP1 glutathione S-transferase pi 1
HDAC6 histone deacetylase 6
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
LRRK1 leucine-rich repeat kinase 1
LYN LYN proto-oncogene, Src family tyrosine kinase
PCNA proliferating cell nuclear antigen
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLCG1 phospholipase C, gamma 1
PLD2 phospholipase D2
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PTK2 protein tyrosine kinase 2
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RGS16 regulator of G-protein signaling 16
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
TLR3 toll-like receptor 3
VAV2 vav 2 guanine nucleotide exchange factor