EGFR Gene Set

Dataset KEA Substrates of Kinases
Category physical interactions
Type kinase
Description epidermal growth factor receptor|The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 1956)
External Link http://www.ncbi.nlm.nih.gov/gene/1956
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Genes

108 substrates of the kinase EGFR from the curated KEA Substrates of Kinases dataset.

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ADRBK1 adrenergic, beta, receptor kinase 1
AGO2 argonaute RISC catalytic component 2
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
ARHGAP35 Rho GTPase activating protein 35
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCAR1 breast cancer anti-estrogen resistance 1
BCR breakpoint cluster region
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAV2 caveolin 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC50 coiled-coil domain containing 50
CD33 CD33 molecule
CD5 CD5 molecule
CDK6 cyclin-dependent kinase 6
CLTA clathrin, light chain A
CLTCL1 clathrin, heavy chain-like 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
EGFR epidermal growth factor receptor
EHD1 EH-domain containing 1
EHD4 EH-domain containing 4
EIF1 eukaryotic translation initiation factor 1
EIF1B eukaryotic translation initiation factor 1B
ENAH enabled homolog (Drosophila)
EPB41 erythrocyte membrane protein band 4.1
EPS15 epidermal growth factor receptor pathway substrate 15
ERBB2 erb-b2 receptor tyrosine kinase 2
EZR ezrin
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGFR1 fibroblast growth factor receptor 1
FYB FYN binding protein
GAB1 GRB2-associated binding protein 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB2 growth factor receptor-bound protein 2
GSTP1 glutathione S-transferase pi 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HDAC6 histone deacetylase 6
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HOXC10 homeobox C10
ICAM1 intercellular adhesion molecule 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
JAK2 Janus kinase 2
KDR kinase insert domain receptor
LRRK1 leucine-rich repeat kinase 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MET MET proto-oncogene, receptor tyrosine kinase
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MUC1 mucin 1, cell surface associated
MYL9 myosin, light chain 9, regulatory
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PABPC1 poly(A) binding protein, cytoplasmic 1
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCNA proliferating cell nuclear antigen
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKD1 protein kinase D1
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PTK2 protein tyrosine kinase 2
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRE protein tyrosine phosphatase, receptor type, E
RAE1 ribonucleic acid export 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS16 regulator of G-protein signaling 16
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCAMP1 secretory carrier membrane protein 1
SCAMP3 secretory carrier membrane protein 3
SEC13 SEC13 homolog (S. cerevisiae)
SFN stratifin
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SH3BP2 SH3-domain binding protein 2
SH3GL2 SH3-domain GRB2-like 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOCS5 suppressor of cytokine signaling 5
SOCS7 suppressor of cytokine signaling 7
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
TEK TEK tyrosine kinase, endothelial
TRIP4 thyroid hormone receptor interactor 4
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
USP24 ubiquitin specific peptidase 24
USP9X ubiquitin specific peptidase 9, X-linked
VAV2 vav 2 guanine nucleotide exchange factor
WASF1 WAS protein family, member 1