Drug-Induced Liver Injury Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment. (Experimental Factor Ontology, EFO_0004228)
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Genes

59 genes associated with the Drug-Induced Liver Injury phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ARHGAP24 Rho GTPase activating protein 24
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BHMT betaine--homocysteine S-methyltransferase
CD44 CD44 molecule (Indian blood group)
CES1 carboxylesterase 1
CES1P1 carboxylesterase 1 pseudogene 1
CES2 carboxylesterase 2
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
GPX1 glutathione peroxidase 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IL10 interleukin 10
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
KCNIP4 Kv channel interacting protein 4
KRT18 keratin 18, type I
KRT8 keratin 8, type II
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NOS2 nitric oxide synthase 2, inducible
NR1I2 nuclear receptor subfamily 1, group I, member 2
PARD3B par-3 family cell polarity regulator beta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SOD2 superoxide dismutase 2, mitochondrial
STAT4 signal transducer and activator of transcription 4
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TNF tumor necrosis factor
TPMT thiopurine S-methyltransferase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7