Drug Toxicity Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

169 genes associated with the Drug Toxicity phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
ACAT1 acetyl-CoA acetyltransferase 1
ACAT2 acetyl-CoA acetyltransferase 2
ACE angiotensin I converting enzyme
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
APOA4 apolipoprotein A-IV
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
AVEN apoptosis, caspase activation inhibitor
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CCL2 chemokine (C-C motif) ligand 2
CDA cytidine deaminase
CETP cholesteryl ester transfer protein, plasma
CHKB choline kinase beta
CHL1 cell adhesion molecule L1-like
CHRM3 cholinergic receptor, muscarinic 3
CPT1A carnitine palmitoyltransferase 1A (liver)
CPT1B carnitine palmitoyltransferase 1B (muscle)
CPT2 carnitine palmitoyltransferase 2
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CYBA cytochrome b-245, alpha polypeptide
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DCK deoxycytidine kinase
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DPYD dihydropyrimidine dehydrogenase
DPYS dihydropyrimidinase
DRD3 dopamine receptor D3
DTWD1 DTW domain containing 1
EGFR epidermal growth factor receptor
ERCC2 excision repair cross-complementation group 2
FABP4 fatty acid binding protein 4, adipocyte
GCG glucagon
GHRH growth hormone releasing hormone
GHRL ghrelin/obestatin prepropeptide
GSK3B glycogen synthase kinase 3 beta
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GYS1 glycogen synthase 1 (muscle)
GYS2 glycogen synthase 2 (liver)
HCP5 HLA complex P5 (non-protein coding)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HRH3 histamine receptor H3
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IL13 interleukin 13
IL4R interleukin 4 receptor
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
KDR kinase insert domain receptor
KRAS Kirsten rat sarcoma viral oncogene homolog
LCAT lecithin-cholesterol acyltransferase
LEPR leptin receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPC lipase, hepatic
LIPE lipase, hormone-sensitive
LIPF lipase, gastric
LIPG lipase, endothelial
LPL lipoprotein lipase
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MDH1 malate dehydrogenase 1, NAD (soluble)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTTP microsomal triglyceride transfer protein
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFKL phosphofructokinase, liver
PFKM phosphofructokinase, muscle
PFKP phosphofructokinase, platelet
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKLR pyruvate kinase, liver and RBC
PKM pyruvate kinase, muscle
POMC proopiomelanocortin
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PSORS1C1 psoriasis susceptibility 1 candidate 1
RARA retinoic acid receptor, alpha
RARB retinoic acid receptor, beta
RARG retinoic acid receptor, gamma
RETN resistin
RFC1 replication factor C (activator 1) 1, 145kDa
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCARB2 scavenger receptor class B, member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOD2 superoxide dismutase 2, mitochondrial
SREBF1 sterol regulatory element binding transcription factor 1
TBL2 transducin (beta)-like 2
TEK TEK tyrosine kinase, endothelial
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TPMT thiopurine S-methyltransferase
TXNRD2 thioredoxin reductase 2
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WDFY4 WDFY family member 4