Drug Hypersensitivity Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

99 genes associated with the Drug Hypersensitivity phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABI3BP ABI family, member 3 (NESH) binding protein
ACE angiotensin I converting enzyme
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX12 arachidonate 12-lipoxygenase
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BICC1 BicC family RNA binding protein 1
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CEP68 centrosomal protein 68kDa
COL24A1 collagen, type XXIV, alpha 1
COL26A1 collagen, type XXVI, alpha 1
CYB5A cytochrome b5 type A (microsomal)
CYB5R3 cytochrome b5 reductase 3
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYSLTR1 cysteinyl leukotriene receptor 1
DAO D-amino-acid oxidase
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXL7 F-box and leucine-rich repeat protein 7
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GRIA1 glutamate receptor, ionotropic, AMPA 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HCP5 HLA complex P5 (non-protein coding)
HDC histidine decarboxylase
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HLF hepatic leukemia factor
HNMT histamine N-methyltransferase
HRH1 histamine receptor H1
HRH2 histamine receptor H2
HRH4 histamine receptor H4
HSPA1A heat shock 70kDa protein 1A
HSPA1L heat shock 70kDa protein 1-like
IFIH1 interferon induced with helicase C domain 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IL10 interleukin 10
IL13 interleukin 13
IL21R interleukin 21 receptor
IL4 interleukin 4
IL4R interleukin 4 receptor
KIF3A kinesin family member 3A
LACTB lactamase, beta
LTA lymphotoxin alpha
LTC4S leukotriene C4 synthase
MICA MHC class I polypeptide-related sequence A
MPO myeloperoxidase
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NLRP3 NLR family, pyrin domain containing 3
NQO1 NAD(P)H dehydrogenase, quinone 1
PTGDR prostaglandin D2 receptor (DP)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD51B RAD51 paralog B
RGS7BP regulator of G-protein signaling 7 binding protein
RIMS1 regulating synaptic membrane exocytosis 1
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TBX21 T-box 21
TBXA2R thromboxane A2 receptor
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TPMT thiopurine S-methyltransferase
ZNF300 zinc finger protein 300