Down Syndrome_CNS - Brain - Cerebellum (MMHCC)_GSE1611 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE1611
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Genes

600 genes differentially expressed during Down Syndrome_CNS - Brain - Cerebellum (MMHCC)_GSE1611 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
MSL1 male-specific lethal 1 homolog (Drosophila) 4.12399
SBNO1 strawberry notch homolog 1 (Drosophila) 4.04794
PLAT plasminogen activator, tissue 3.60901
BCAT1 branched chain amino-acid transaminase 1, cytosolic 3.27561
PDPK1 3-phosphoinositide dependent protein kinase 1 3.17757
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 3.16369
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 3.15188
SOD1 superoxide dismutase 1, soluble 3.13477
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 3.02553
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 3.0142
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.99497
GOLGA7 golgin A7 2.96466
CDCA7L cell division cycle associated 7-like 2.9488
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 2.86393
LAPTM5 lysosomal protein transmembrane 5 2.86085
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 2.82354
USP38 ubiquitin specific peptidase 38 2.81475
ATOX1 antioxidant 1 copper chaperone 2.77865
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.71379
ELF4 E74-like factor 4 (ets domain transcription factor) 2.70617
STAT5A signal transducer and activator of transcription 5A 2.69345
SH2B1 SH2B adaptor protein 1 2.68985
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.64894
COX7B cytochrome c oxidase subunit VIIb 2.64395
AMMECR1L AMMECR1-like 2.60121
CAPRIN2 caprin family member 2 2.59474
UBE2K ubiquitin-conjugating enzyme E2K 2.55939
RAB5C RAB5C, member RAS oncogene family 2.5536
COL15A1 collagen, type XV, alpha 1 2.53004
UBC ubiquitin C 2.50724
ILK integrin-linked kinase 2.50442
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 2.49974
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 2.4916
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.48876
CDK9 cyclin-dependent kinase 9 2.47933
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 2.42402
CBR1 carbonyl reductase 1 2.4237
PTK2B protein tyrosine kinase 2 beta 2.42129
ACLY ATP citrate lyase 2.40068
CALU calumenin 2.38888
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 2.38617
HPS1 Hermansky-Pudlak syndrome 1 2.37929
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 2.34152
WNK2 WNK lysine deficient protein kinase 2 2.33897
SON SON DNA binding protein 2.33204
ZFPM1 zinc finger protein, FOG family member 1 2.32944
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.31993
SHROOM3 shroom family member 3 2.31591
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.31179
TYRP1 tyrosinase-related protein 1 2.31039
ZYG11B zyg-11 family member B, cell cycle regulator 2.3091
RAMP2 receptor (G protein-coupled) activity modifying protein 2 2.28922
DCN decorin 2.28003
KIF22 kinesin family member 22 2.27644
LAT linker for activation of T cells 2.2746
EXOC7 exocyst complex component 7 2.2328
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 2.2175
ZCCHC3 zinc finger, CCHC domain containing 3 2.21191
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2.20544
CNBP CCHC-type zinc finger, nucleic acid binding protein 2.17955
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 2.17384
PGK1 phosphoglycerate kinase 1 2.16875
ACSL1 acyl-CoA synthetase long-chain family member 1 2.1662
GSK3A glycogen synthase kinase 3 alpha 2.14794
CXCL12 chemokine (C-X-C motif) ligand 12 2.14113
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 2.14092
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 2.14091
MYEOV2 myeloma overexpressed 2 2.13859
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.13203
ARFIP2 ADP-ribosylation factor interacting protein 2 2.13002
MRPS28 mitochondrial ribosomal protein S28 2.09537
ZAN zonadhesin (gene/pseudogene) 2.08935
IFT27 intraflagellar transport 27 2.06854
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.06503
PRPF19 pre-mRNA processing factor 19 2.05971
LIAS lipoic acid synthetase 2.05965
SREBF1 sterol regulatory element binding transcription factor 1 2.04427
DSCR3 Down syndrome critical region 3 2.03594
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.03045
ANGPTL2 angiopoietin-like 2 2.02846
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 2.0271
CLTB clathrin, light chain B 2.00956
LIMK1 LIM domain kinase 1 1.99601
GIPC1 GIPC PDZ domain containing family, member 1 1.99116
RPS29 ribosomal protein S29 1.98261
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 1.97499
ACTL6A actin-like 6A 1.96769
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 1.96182
FERMT3 fermitin family member 3 1.95443
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 1.94355
VKORC1 vitamin K epoxide reductase complex, subunit 1 1.93841
CIC capicua transcriptional repressor 1.9354
PTHLH parathyroid hormone-like hormone 1.92786
WDR81 WD repeat domain 81 1.92754
SNRPB2 small nuclear ribonucleoprotein polypeptide B 1.92522
LRRC8A leucine rich repeat containing 8 family, member A 1.90997
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 1.90891
GM2A GM2 ganglioside activator 1.90175
CRYGS crystallin, gamma S 1.90097
RPE ribulose-5-phosphate-3-epimerase 1.89546
IL10RB interleukin 10 receptor, beta 1.89338
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 1.87555
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.86572
LIMD1 LIM domains containing 1 1.86255
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 1.85461
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 1.84442
DYNLL2 dynein, light chain, LC8-type 2 1.84133
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 1.8397
TGDS TDP-glucose 4,6-dehydratase 1.8373
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 1.83705
LUM lumican 1.8324
CTGF connective tissue growth factor 1.83065
KRTAP13-2 keratin associated protein 13-2 1.8232
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.82299
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 1.81972
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 1.81969
DPYSL4 dihydropyrimidinase-like 4 1.81565
BRIX1 BRX1, biogenesis of ribosomes 1.81467
C5ORF15 chromosome 5 open reading frame 15 1.80981
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.80821
CANT1 calcium activated nucleotidase 1 1.8058
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 1.8054
TSTA3 tissue specific transplantation antigen P35B 1.80189
LEFTY1 left-right determination factor 1 1.80062
PITPNA phosphatidylinositol transfer protein, alpha 1.80039
IFNAR2 interferon (alpha, beta and omega) receptor 2 1.79768
CLDND1 claudin domain containing 1 1.78462
WDR5 WD repeat domain 5 1.77639
FAM105A family with sequence similarity 105, member A 1.77185
TAOK3 TAO kinase 3 1.76921
TMED8 transmembrane emp24 protein transport domain containing 8 1.76751
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 1.75763
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 1.75707
MNT MAX network transcriptional repressor 1.75233
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 1.74842
GPI glucose-6-phosphate isomerase 1.74184
KANSL2 KAT8 regulatory NSL complex subunit 2 1.74019
PHF23 PHD finger protein 23 1.73778
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 1.73361
CAPN10 calpain 10 1.7249
PLRG1 pleiotropic regulator 1 1.7216
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 1.72157
DES desmin 1.71829
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 1.71358
RBMS1 RNA binding motif, single stranded interacting protein 1 1.70574
VWF von Willebrand factor 1.70178
WDTC1 WD and tetratricopeptide repeats 1 1.69726
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 1.69518
MARK2 MAP/microtubule affinity-regulating kinase 2 1.68809
OC90 otoconin 90 1.68068
TUBB6 tubulin, beta 6 class V 1.68043
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 1.67703
MAP3K12 mitogen-activated protein kinase kinase kinase 12 1.67277
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.66408
INPP5K inositol polyphosphate-5-phosphatase K 1.6625
LAMA4 laminin, alpha 4 1.66099
PDLIM7 PDZ and LIM domain 7 (enigma) 1.65819
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 1.65633
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 1.6555
SSTR3 somatostatin receptor 3 1.64984
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 1.64545
WNK1 WNK lysine deficient protein kinase 1 1.63845
TBCE tubulin folding cofactor E 1.63769
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 1.63621
SP1 Sp1 transcription factor 1.6339
ANKZF1 ankyrin repeat and zinc finger domain containing 1 1.63271
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1.62848
ATM ATM serine/threonine kinase 1.62469
GP5 glycoprotein V (platelet) 1.62192
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 1.62088
ZFP42 ZFP42 zinc finger protein 1.61807
RPL38 ribosomal protein L38 1.618
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.61484
CYB5R1 cytochrome b5 reductase 1 1.6106
PKP2 plakophilin 2 1.6097
ITPK1 inositol-tetrakisphosphate 1-kinase 1.60959
SGPL1 sphingosine-1-phosphate lyase 1 1.60763
PSAT1 phosphoserine aminotransferase 1 1.60536
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 1.59381
OPHN1 oligophrenin 1 1.59253
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 1.58928
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.58159
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 1.57968
MAP2K6 mitogen-activated protein kinase kinase 6 1.57394
INS insulin 1.57306
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 1.57144
MOB1B MOB kinase activator 1B 1.56385
JAGN1 jagunal homolog 1 (Drosophila) 1.563
C12ORF45 chromosome 12 open reading frame 45 1.56055
BCL6B B-cell CLL/lymphoma 6, member B 1.55761
DNPEP aspartyl aminopeptidase 1.55614
DMPK dystrophia myotonica-protein kinase 1.55395
CMA1 chymase 1, mast cell 1.53707
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 1.53423
BLK BLK proto-oncogene, Src family tyrosine kinase 1.53327
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.53188
TNNC2 troponin C type 2 (fast) 1.52387
IRF6 interferon regulatory factor 6 1.5224
YY1 YY1 transcription factor 1.52177
F2 coagulation factor II (thrombin) 1.51924
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 1.51425
PGLYRP1 peptidoglycan recognition protein 1 1.51311
MRPL40 mitochondrial ribosomal protein L40 1.51195
CCL22 chemokine (C-C motif) ligand 22 1.50821
MC5R melanocortin 5 receptor 1.50698
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1.50232
MYLK myosin light chain kinase 1.4997
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 1.49526
AAK1 AP2 associated kinase 1 1.49277
GHR growth hormone receptor 1.48748
ITSN1 intersectin 1 (SH3 domain protein) 1.48098
FBXW4 F-box and WD repeat domain containing 4 1.47886
KLRB1 killer cell lectin-like receptor subfamily B, member 1 1.47321
C15ORF39 chromosome 15 open reading frame 39 1.47199
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1.4706
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.46846
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 1.46773
MRPL28 mitochondrial ribosomal protein L28 1.46432
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 1.46131
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 1.46007
PRKD2 protein kinase D2 1.4595
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 1.45906
HADH hydroxyacyl-CoA dehydrogenase 1.45872
GIP gastric inhibitory polypeptide 1.45611
RNF166 ring finger protein 166 1.45601
EXTL3 exostosin-like glycosyltransferase 3 1.45438
ACAA1 acetyl-CoA acyltransferase 1 1.45414
SEC31A SEC31 homolog A (S. cerevisiae) 1.4528
STK24 serine/threonine kinase 24 1.45081
GJA10 gap junction protein, alpha 10, 62kDa 1.45079
SMAD6 SMAD family member 6 1.45027
WNT2B wingless-type MMTV integration site family, member 2B 1.45004
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.44841
OR2C1 olfactory receptor, family 2, subfamily C, member 1 1.44832
ESYT1 extended synaptotagmin-like protein 1 1.44765
STK11IP serine/threonine kinase 11 interacting protein 1.44685
CDK5RAP3 CDK5 regulatory subunit associated protein 3 1.44513
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 1.44498
DTNB dystrobrevin, beta 1.44467
FAM189B family with sequence similarity 189, member B 1.44199
STYX serine/threonine/tyrosine interacting protein 1.43882
COQ10A coenzyme Q10 homolog A (S. cerevisiae) 1.4376
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 1.43691
PHGDH phosphoglycerate dehydrogenase 1.43626
MAD2L1BP MAD2L1 binding protein 1.43606
EPHA2 EPH receptor A2 1.43433
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 1.43134
MRPL41 mitochondrial ribosomal protein L41 1.4305
NRSN1 neurensin 1 1.42813
MOCS2 molybdenum cofactor synthesis 2 1.42729
SYNGR4 synaptogyrin 4 1.42079
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 1.41602
SMAGP small cell adhesion glycoprotein 1.41569
PAPOLA poly(A) polymerase alpha 1.41294
PLXNB2 plexin B2 1.4112
TGS1 trimethylguanosine synthase 1 1.40596
TH tyrosine hydroxylase 1.40519
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 1.40466
RNF26 ring finger protein 26 1.40436
CSF1R colony stimulating factor 1 receptor 1.4042
MEMO1 mediator of cell motility 1 1.40167
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 1.39997
COX4I1 cytochrome c oxidase subunit IV isoform 1 1.39928
METTL20 methyltransferase like 20 1.39694
TERF2 telomeric repeat binding factor 2 1.39605
OR10J5 olfactory receptor, family 10, subfamily J, member 5 1.39532
NELL2 NEL-like 2 (chicken) 1.39422
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 1.3938
GCSH glycine cleavage system protein H (aminomethyl carrier) 1.39077
CPLX2 complexin 2 1.38768
LSR lipolysis stimulated lipoprotein receptor 1.38534
LRRC58 leucine rich repeat containing 58 1.38052
ASF1A anti-silencing function 1A histone chaperone 1.37792
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 1.37607
IPO11 importin 11 1.37491
CAPN3 calpain 3, (p94) 1.37319
HMGN1 high mobility group nucleosome binding domain 1 1.37234
BARX2 BARX homeobox 2 1.37093
FBXO8 F-box protein 8 1.37022
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 1.36955
AP3B1 adaptor-related protein complex 3, beta 1 subunit 1.36169
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 1.36144
LIG3 ligase III, DNA, ATP-dependent 1.36091
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.35546
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 1.35545
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.35089
SCAMP3 secretory carrier membrane protein 3 1.3475
ITLN1 intelectin 1 (galactofuranose binding) 1.34322
C1ORF86 chromosome 1 open reading frame 86 1.34249
FAM50B family with sequence similarity 50, member B 1.34021
NIPBL Nipped-B homolog (Drosophila) 1.33871
C14ORF2 chromosome 14 open reading frame 2 1.33843
C2ORF49 chromosome 2 open reading frame 49 1.33806
NUB1 negative regulator of ubiquitin-like proteins 1 1.33676
ADRBK1 adrenergic, beta, receptor kinase 1 1.33594
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.33324
S100A3 S100 calcium binding protein A3 1.33118
HINFP histone H4 transcription factor 1.32778
CLIP4 CAP-GLY domain containing linker protein family, member 4 1.32641
HTATSF1 HIV-1 Tat specific factor 1 1.32629

decreased expression

Symbol Name Standardized Value
RRAGA Ras-related GTP binding A -3.72428
ARL6 ADP-ribosylation factor-like 6 -3.58929
STX6 syntaxin 6 -3.56273
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -3.23065
ANAPC13 anaphase promoting complex subunit 13 -3.21688
CDC26 cell division cycle 26 -3.14488
ZNF316 zinc finger protein 316 -3.13344
RABGGTB Rab geranylgeranyltransferase, beta subunit -3.1185
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -3.08407
CUL1 cullin 1 -2.97675
SNX12 sorting nexin 12 -2.96913
KIF1B kinesin family member 1B -2.93603
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase -2.88109
RNF44 ring finger protein 44 -2.77469
RHOT1 ras homolog family member T1 -2.75805
CANX calnexin -2.758
CD63 CD63 molecule -2.74513
CAB39 calcium binding protein 39 -2.7446
NKX2-2 NK2 homeobox 2 -2.72235
JMJD6 jumonji domain containing 6 -2.68885
KIF1A kinesin family member 1A -2.64561
CUL4A cullin 4A -2.61336
GTPBP4 GTP binding protein 4 -2.60889
RFK riboflavin kinase -2.6045
MED24 mediator complex subunit 24 -2.58392
UBQLN1 ubiquilin 1 -2.56906
KIAA0020 KIAA0020 -2.56775
RALY RALY heterogeneous nuclear ribonucleoprotein -2.55599
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.53205
RSAD2 radical S-adenosyl methionine domain containing 2 -2.52972
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.52237
C9ORF114 chromosome 9 open reading frame 114 -2.49386
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa -2.4733
ARF3 ADP-ribosylation factor 3 -2.46685
BABAM1 BRISC and BRCA1 A complex member 1 -2.46473
FBXW2 F-box and WD repeat domain containing 2 -2.43073
CNOT8 CCR4-NOT transcription complex, subunit 8 -2.42437
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -2.40904
ELL elongation factor RNA polymerase II -2.36657
PTEN phosphatase and tensin homolog -2.35737
FNTA farnesyltransferase, CAAX box, alpha -2.30948
FRYL FRY-like -2.30097
HARS histidyl-tRNA synthetase -2.29652
ZIC3 Zic family member 3 -2.26604
PTCD2 pentatricopeptide repeat domain 2 -2.26202
XPO7 exportin 7 -2.25494
RNF8 ring finger protein 8, E3 ubiquitin protein ligase -2.25379
TEN1 TEN1 CST complex subunit -2.24484
TMEM11 transmembrane protein 11 -2.23832
RPP14 ribonuclease P/MRP 14kDa subunit -2.22508
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -2.22382
RAB7A RAB7A, member RAS oncogene family -2.19251
TSPYL1 TSPY-like 1 -2.18607
PDCD2L programmed cell death 2-like -2.17275
ZC3H12C zinc finger CCCH-type containing 12C -2.16279
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -2.15674
SRSF10 serine/arginine-rich splicing factor 10 -2.15102
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -2.11767
FLOT2 flotillin 2 -2.11293
ERP44 endoplasmic reticulum protein 44 -2.1092
BPGM 2,3-bisphosphoglycerate mutase -2.10622
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -2.10244
UNC50 unc-50 homolog (C. elegans) -2.09693
ARL2BP ADP-ribosylation factor-like 2 binding protein -2.08569
CTCF CCCTC-binding factor (zinc finger protein) -2.08561
ZNHIT2 zinc finger, HIT-type containing 2 -2.08243
FJX1 four jointed box 1 (Drosophila) -2.06469
TRAM1 translocation associated membrane protein 1 -2.0601
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.04106
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -2.03995
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.02423
EGLN1 egl-9 family hypoxia-inducible factor 1 -2.0237
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -2.02268
UFM1 ubiquitin-fold modifier 1 -2.00829
FAM69B family with sequence similarity 69, member B -2.00518
WDR48 WD repeat domain 48 -2.00134
COMTD1 catechol-O-methyltransferase domain containing 1 -1.98409
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -1.98224
TWSG1 twisted gastrulation BMP signaling modulator 1 -1.98168
KIF5C kinesin family member 5C -1.9751
THAP7 THAP domain containing 7 -1.97272
EYA1 EYA transcriptional coactivator and phosphatase 1 -1.95807
TARS threonyl-tRNA synthetase -1.95558
ARL8B ADP-ribosylation factor-like 8B -1.952
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma -1.93505
IARS isoleucyl-tRNA synthetase -1.93376
KDM1A lysine (K)-specific demethylase 1A -1.93357
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -1.93318
ALG3 ALG3, alpha-1,3- mannosyltransferase -1.93053
ZNF706 zinc finger protein 706 -1.92999
OAZ2 ornithine decarboxylase antizyme 2 -1.91226
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -1.90736
HSPA8 heat shock 70kDa protein 8 -1.89118
PARK7 parkinson protein 7 -1.89003
RCAN3 RCAN family member 3 -1.88906
SEC24C SEC24 family member C -1.88866
TCEA1 transcription elongation factor A (SII), 1 -1.88854
ANKRD46 ankyrin repeat domain 46 -1.88831
CUTA cutA divalent cation tolerance homolog (E. coli) -1.88308
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -1.88307
S100A10 S100 calcium binding protein A10 -1.87903
TRIM37 tripartite motif containing 37 -1.86375
TRAPPC5 trafficking protein particle complex 5 -1.8622
UNC45A unc-45 homolog A (C. elegans) -1.85863
MIA3 melanoma inhibitory activity family, member 3 -1.85846
HSPA9 heat shock 70kDa protein 9 (mortalin) -1.85061
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -1.84909
EMD emerin -1.8425
CRNKL1 crooked neck pre-mRNA splicing factor 1 -1.84076
CHD1 chromodomain helicase DNA binding protein 1 -1.84071
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -1.84008
PABPN1 poly(A) binding protein, nuclear 1 -1.8346
TPST1 tyrosylprotein sulfotransferase 1 -1.83393
VCL vinculin -1.83164
ALOXE3 arachidonate lipoxygenase 3 -1.82706
PIAS3 protein inhibitor of activated STAT, 3 -1.82388
PYCR2 pyrroline-5-carboxylate reductase family, member 2 -1.81804
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa -1.81661
ANTXR2 anthrax toxin receptor 2 -1.81342
GTPBP1 GTP binding protein 1 -1.80904
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) -1.80642
MRPL44 mitochondrial ribosomal protein L44 -1.79517
ACIN1 apoptotic chromatin condensation inducer 1 -1.79315
ANAPC16 anaphase promoting complex subunit 16 -1.7922
ZNFX1 zinc finger, NFX1-type containing 1 -1.78927
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -1.78638
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 -1.78175
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 -1.78104
ETHE1 ethylmalonic encephalopathy 1 -1.77715
TIMELESS timeless circadian clock -1.76991
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -1.76969
PICK1 protein interacting with PRKCA 1 -1.76885
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -1.76592
F11R F11 receptor -1.76581
COPE coatomer protein complex, subunit epsilon -1.76546
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -1.76362
FIBCD1 fibrinogen C domain containing 1 -1.76345
MBD3 methyl-CpG binding domain protein 3 -1.75612
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -1.74871
TM9SF3 transmembrane 9 superfamily member 3 -1.74441
AGFG1 ArfGAP with FG repeats 1 -1.74093
SHFM1 split hand/foot malformation (ectrodactyly) type 1 -1.73853
DGCR14 DiGeorge syndrome critical region gene 14 -1.73633
PCID2 PCI domain containing 2 -1.73038
MID1IP1 MID1 interacting protein 1 -1.7242
RIN2 Ras and Rab interactor 2 -1.72417
BAG2 BCL2-associated athanogene 2 -1.72397
DERL1 derlin 1 -1.72373
SLC25A39 solute carrier family 25, member 39 -1.72314
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -1.72254
ZNF574 zinc finger protein 574 -1.71844
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -1.71812
INO80E INO80 complex subunit E -1.71489
LUC7L2 LUC7-like 2 (S. cerevisiae) -1.71325
NAP1L2 nucleosome assembly protein 1-like 2 -1.7122
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -1.71007
PRPF31 pre-mRNA processing factor 31 -1.70488
SPRYD4 SPRY domain containing 4 -1.7047
FLII flightless I homolog (Drosophila) -1.70259
FAM13B family with sequence similarity 13, member B -1.6886
TMEM179B transmembrane protein 179B -1.6811
KCTD17 potassium channel tetramerization domain containing 17 -1.67866
RPP30 ribonuclease P/MRP 30kDa subunit -1.66636
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -1.66447
TARBP2 TAR (HIV-1) RNA binding protein 2 -1.66097
C8ORF37 chromosome 8 open reading frame 37 -1.65974
FAM134A family with sequence similarity 134, member A -1.65383
GAPDH glyceraldehyde-3-phosphate dehydrogenase -1.65159
ALAS2 5'-aminolevulinate synthase 2 -1.65144
TRIM27 tripartite motif containing 27 -1.65085
EFTUD2 elongation factor Tu GTP binding domain containing 2 -1.65055
PCBP4 poly(rC) binding protein 4 -1.64938
FAM96A family with sequence similarity 96, member A -1.63829
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -1.63786
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -1.63482
CCND3 cyclin D3 -1.63482
SART3 squamous cell carcinoma antigen recognized by T cells 3 -1.63192
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -1.63064
TMEM208 transmembrane protein 208 -1.63016
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -1.63002
HACD3 3-hydroxyacyl-CoA dehydratase 3 -1.62538
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -1.62462
NSG1 neuron specific gene family member 1 -1.62295
STAG2 stromal antigen 2 -1.62282
SIN3A SIN3 transcription regulator family member A -1.61748
OLFM1 olfactomedin 1 -1.61434
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -1.6074
LONP2 lon peptidase 2, peroxisomal -1.60556
ZBTB45 zinc finger and BTB domain containing 45 -1.6051
PLIN2 perilipin 2 -1.60332
FBRS fibrosin -1.6027
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit -1.59605
RNMTL1 RNA methyltransferase like 1 -1.58869
SF3A1 splicing factor 3a, subunit 1, 120kDa -1.58657
NDNL2 necdin-like 2 -1.57086
GLRA1 glycine receptor, alpha 1 -1.56082
MTMR1 myotubularin related protein 1 -1.56061
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -1.55686
RAB5B RAB5B, member RAS oncogene family -1.55551
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -1.55493
TSPAN5 tetraspanin 5 -1.55356
FAM114A2 family with sequence similarity 114, member A2 -1.55342
LIN9 lin-9 DREAM MuvB core complex component -1.55073
FZD9 frizzled class receptor 9 -1.54754
FAM46C family with sequence similarity 46, member C -1.54695
EXOC8 exocyst complex component 8 -1.5424
ARL5A ADP-ribosylation factor-like 5A -1.54006
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -1.53771
PEX11B peroxisomal biogenesis factor 11 beta -1.53664
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) -1.53396
FBXW11 F-box and WD repeat domain containing 11 -1.53379
SAFB scaffold attachment factor B -1.52926
SF3A3 splicing factor 3a, subunit 3, 60kDa -1.52914
COMMD9 COMM domain containing 9 -1.52605
AK2 adenylate kinase 2 -1.52369
TMEM30A transmembrane protein 30A -1.52306
PBX2 pre-B-cell leukemia homeobox 2 -1.52048
TRIM46 tripartite motif containing 46 -1.51572
TSC2 tuberous sclerosis 2 -1.51337
GPN2 GPN-loop GTPase 2 -1.51214
PLXNA1 plexin A1 -1.5107
ITFG1 integrin alpha FG-GAP repeat containing 1 -1.49761
BATF3 basic leucine zipper transcription factor, ATF-like 3 -1.48883
FOXJ1 forkhead box J1 -1.48495
EFTUD1 elongation factor Tu GTP binding domain containing 1 -1.48448
MRPL18 mitochondrial ribosomal protein L18 -1.48347
GOLGA3 golgin A3 -1.47456
STOML2 stomatin (EPB72)-like 2 -1.47323
RCC2 regulator of chromosome condensation 2 -1.47243
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -1.47197
SRPK1 SRSF protein kinase 1 -1.4713
TBPL1 TBP-like 1 -1.47009
PLEKHA7 pleckstrin homology domain containing, family A member 7 -1.47004
MTX1 metaxin 1 -1.46931
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -1.46798
C8ORF33 chromosome 8 open reading frame 33 -1.46248
TIGD5 tigger transposable element derived 5 -1.46156
SMAD2 SMAD family member 2 -1.46006
NUBP1 nucleotide binding protein 1 -1.45718
PPP4R2 protein phosphatase 4, regulatory subunit 2 -1.45307
MZT2A mitotic spindle organizing protein 2A -1.45123
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -1.4501
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -1.44981
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -1.44839
NLK nemo-like kinase -1.44569
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -1.44307
RRAGD Ras-related GTP binding D -1.4377
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -1.43743
PDIA4 protein disulfide isomerase family A, member 4 -1.43684
ESD esterase D -1.43605
ACP1 acid phosphatase 1, soluble -1.43417
HMBS hydroxymethylbilane synthase -1.43183
NKX3-2 NK3 homeobox 2 -1.43131
ABHD5 abhydrolase domain containing 5 -1.42825
MSN moesin -1.42717
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) -1.42503
MED20 mediator complex subunit 20 -1.42277
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -1.42244
CORO1A coronin, actin binding protein, 1A -1.42155
HIF3A hypoxia inducible factor 3, alpha subunit -1.42104
HES1 hes family bHLH transcription factor 1 -1.42024
ADPRH ADP-ribosylarginine hydrolase -1.41956
ILF2 interleukin enhancer binding factor 2 -1.41926
MRPS2 mitochondrial ribosomal protein S2 -1.41688
NR2F6 nuclear receptor subfamily 2, group F, member 6 -1.41645
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -1.41545
SQSTM1 sequestosome 1 -1.40954
TEX30 testis expressed 30 -1.406
GRB2 growth factor receptor-bound protein 2 -1.39886
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -1.39772
ARPP19 cAMP-regulated phosphoprotein, 19kDa -1.39732
ENSA endosulfine alpha -1.39428
EEA1 early endosome antigen 1 -1.39385
DIDO1 death inducer-obliterator 1 -1.39323
ATF6B activating transcription factor 6 beta -1.39094
PPP1R7 protein phosphatase 1, regulatory subunit 7 -1.3898
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -1.38564
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -1.38211
POMP proteasome maturation protein -1.37853
C18ORF8 chromosome 18 open reading frame 8 -1.3741
PES1 pescadillo ribosomal biogenesis factor 1 -1.37378
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -1.37238
FOXK2 forkhead box K2 -1.37191
RIT1 Ras-like without CAAX 1 -1.37113
DOHH deoxyhypusine hydroxylase/monooxygenase -1.37087
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -1.36968
USP21 ubiquitin specific peptidase 21 -1.36614
ICT1 immature colon carcinoma transcript 1 -1.36449
CENPC centromere protein C -1.36313
IDE insulin-degrading enzyme -1.36133
CCDC63 coiled-coil domain containing 63 -1.36038
PEX13 peroxisomal biogenesis factor 13 -1.35325
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 -1.35309
CLK3 CDC-like kinase 3 -1.35056
ARL1 ADP-ribosylation factor-like 1 -1.34874
PML promyelocytic leukemia -1.34554
SAR1A secretion associated, Ras related GTPase 1A -1.34079
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide -1.34059
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -1.33969
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -1.33926