Double-Strand Break Repair Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. (Gene Ontology, GO_0006302)
Similar Terms
Downloads & Tools

Genes

23 proteins participating in the Double-Strand Break Repair pathway from the Reactome Pathways dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATM ATM serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
H2AFX H2A histone family, member X
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
MDC1 mediator of DNA-damage checkpoint 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD52 RAD52 homolog (S. cerevisiae)
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
TDP1 tyrosyl-DNA phosphodiesterase 1
TP53BP1 tumor protein p53 binding protein 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6