Disorders of Excessive Somnolence Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D006970
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Genes

234 genes/proteins associated with the disease Disorders of Excessive Somnolence from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.50095
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.47823
PRL prolactin 2.43741
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.4344
DRD2 dopamine receptor D2 2.4202
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.37855
FOS FBJ murine osteosarcoma viral oncogene homolog 2.29521
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.28826
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.23663
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.21294
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 2.17029
TNF tumor necrosis factor 2.14429
BDNF brain-derived neurotrophic factor 2.12738
CAT catalase 2.08356
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.0789
DRD1 dopamine receptor D1 2.0557
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 2.00968
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.00842
EGR1 early growth response 1 1.98741
CRH corticotropin releasing hormone 1.95315
BAX BCL2-associated X protein 1.95087
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.91267
IL6 interleukin 6 1.91067
HRH1 histamine receptor H1 1.89747
BCL2 B-cell CLL/lymphoma 2 1.88964
INHBE inhibin, beta E 1.87194
MAPK1 mitogen-activated protein kinase 1 1.87042
MAPK3 mitogen-activated protein kinase 3 1.83485
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.83254
DRD3 dopamine receptor D3 1.82726
JUN jun proto-oncogene 1.82341
NPY neuropeptide Y 1.79846
CDK5 cyclin-dependent kinase 5 1.77121
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.74842
C10ORF10 chromosome 10 open reading frame 10 1.72488
TAGLN transgelin 1.71789
IL1B interleukin 1, beta 1.70988
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.70636
NUPR1 nuclear protein, transcriptional regulator, 1 1.7043
GSK3B glycogen synthase kinase 3 beta 1.69993
NOS2 nitric oxide synthase 2, inducible 1.69701
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.69017
GSTP1 glutathione S-transferase pi 1 1.69017
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.67159
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.66921
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.64416
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.64056
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.64056
TH tyrosine hydroxylase 1.63608
COMT catechol-O-methyltransferase 1.63227
SOD1 superoxide dismutase 1, soluble 1.63227
OPRM1 opioid receptor, mu 1 1.63138
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.62379
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.62357
NGF nerve growth factor (beta polypeptide) 1.61295
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.60105
IFNG interferon, gamma 1.58983
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.58983
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.58795
PENK proenkephalin 1.58303
VEGFA vascular endothelial growth factor A 1.57735
CCND1 cyclin D1 1.56994
CREB1 cAMP responsive element binding protein 1 1.56804
FABP1 fatty acid binding protein 1, liver 1.56435
POMC proopiomelanocortin 1.56117
CXCL8 chemokine (C-X-C motif) ligand 8 1.54159
FAS Fas cell surface death receptor 1.53308
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.52865
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.52086
AVP arginine vasopressin 1.5181
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.51305
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.50903
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.50877
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.50146
PDYN prodynorphin 1.49432
INS insulin 1.48428
RELN reelin 1.48351
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.46436
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.46436
FNDC4 fibronectin type III domain containing 4 1.43266
CYP3A cytochrome P450, family 3, subfamily A 1.4164
NGFR nerve growth factor receptor 1.4164
ARC activity-regulated cytoskeleton-associated protein 1.4164
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.41285
CCL2 chemokine (C-C motif) ligand 2 1.41119
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.4076
S100A9 S100 calcium binding protein A9 1.40705
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.40486
HMOX1 heme oxygenase 1 1.39897
SREBF1 sterol regulatory element binding transcription factor 1 1.39646
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.38974
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.381
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.37303
TAC1 tachykinin, precursor 1 1.37132
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.36533
HOMER1 homer scaffolding protein 1 1.36447
IL1A interleukin 1, alpha 1.36361
IL2 interleukin 2 1.35906
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.35877
GH1 growth hormone 1 1.35877
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 1.35502
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.35069
TRH thyrotropin-releasing hormone 1.34459
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.34401
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.33909
MAOA monoamine oxidase A 1.33434
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.33081
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.33081
BCL2L1 BCL2-like 1 1.33052
CNR1 cannabinoid receptor 1 (brain) 1.32816
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.31985
IL10 interleukin 10 1.31867
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.31867
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.31686
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.31416
IL4 interleukin 4 1.31059
GAL galanin/GMAP prepropeptide 1.30451
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 1.29256
CES2 carboxylesterase 2 1.29103
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.28765
ADRA2A adrenoceptor alpha 2A 1.28734
DUSP1 dual specificity phosphatase 1 1.28549
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.28058
GDNF glial cell derived neurotrophic factor 1.28058
DRD4 dopamine receptor D4 1.27845
GRIK2 glutamate receptor, ionotropic, kainate 2 1.27626
SIGMAR1 sigma non-opioid intracellular receptor 1 1.27409
CXCL10 chemokine (C-X-C motif) ligand 10 1.26514
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.26483
TP53 tumor protein p53 1.25525
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.25494
TSPO translocator protein (18kDa) 1.24655
OPRK1 opioid receptor, kappa 1 1.24056
PDE4B phosphodiesterase 4B, cAMP-specific 1.23488
NEFH neurofilament, heavy polypeptide 1.23488
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.23169
SREBF2 sterol regulatory element binding transcription factor 2 1.2279
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.22727
MAPK14 mitogen-activated protein kinase 14 1.22599
JUNB jun B proto-oncogene 1.22145
NRP1 neuropilin 1 1.21791
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.21435
EGR3 early growth response 3 1.21239
GSTM1 glutathione S-transferase mu 1 1.20881
PLXNB1 plexin B1 1.20719
RORA RAR-related orphan receptor A 1.20493
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.20229
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.2013
MAPK8 mitogen-activated protein kinase 8 1.20064
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 1.1977
SELL selectin L 1.19047
ADIPOQ adiponectin, C1Q and collagen domain containing 1.18521
SOD2 superoxide dismutase 2, mitochondrial 1.18521
EGR2 early growth response 2 1.18326
ADCY8 adenylate cyclase 8 (brain) 1.18093
ALB albumin 1.1786
PARP1 poly (ADP-ribose) polymerase 1 1.1786
LEP leptin 1.1786
HPN hepsin 1.17728
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.17728
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.17662
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.17333
MAP2 microtubule-associated protein 2 1.17333
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 1.17
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.16335
IGF1 insulin-like growth factor 1 (somatomedin C) 1.16001
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.16001
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.15865
GLUL glutamate-ammonia ligase 1.15627
MAOB monoamine oxidase B 1.15391
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.15324
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.14098
S100B S100 calcium binding protein B 1.14098
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.13862
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.13109
FSHB follicle stimulating hormone, beta polypeptide 1.12426
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.12219
ACHE acetylcholinesterase (Yt blood group) 1.12014
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.10734
NCAN neurocan 1.10459
APP amyloid beta (A4) precursor protein 1.10388
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.09822
MMP13 matrix metallopeptidase 13 1.09681
FASLG Fas ligand (TNF superfamily, member 6) 1.09262
BCHE butyrylcholinesterase 1.09083
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.09047
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 1.0894
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.08655
SC5D sterol-C5-desaturase 1.08655
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 1.08513
EFNA2 ephrin-A2 1.08301
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.07875
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.0784
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.0766
PRLR prolactin receptor 1.07625
GNAS GNAS complex locus 1.07093
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.07093
TGFB1 transforming growth factor, beta 1 1.06952
MPO myeloperoxidase 1.06552
CDK4 cyclin-dependent kinase 4 1.06442
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 1.06333
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.06152
PER1 period circadian clock 1 1.0608
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.05936
PNPLA3 patatin-like phospholipase domain containing 3 1.05685
EFNB1 ephrin-B1 1.05685
LMO7 LIM domain 7 1.05685
POR P450 (cytochrome) oxidoreductase 1.05535
SYPL1 synaptophysin-like 1 1.05423
LHB luteinizing hormone beta polypeptide 1.05386
DDIT3 DNA-damage-inducible transcript 3 1.05386
GFAP glial fibrillary acidic protein 1.04794
TKT transketolase 1.04721
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 1.04647
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 1.04647
REN renin 1.04051
ICAM1 intercellular adhesion molecule 1 1.04051
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.03678
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 1.0353
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.03382
S100A8 S100 calcium binding protein A8 1.02896
GCLM glutamate-cysteine ligase, modifier subunit 1.02746
CCK cholecystokinin 1.02746
OSBPL8 oxysterol binding protein-like 8 1.02634
VCAM1 vascular cell adhesion molecule 1 1.02485
GPX2 glutathione peroxidase 2 1.02447
LDLR low density lipoprotein receptor 1.02225
HIGD1A HIG1 hypoxia inducible domain family, member 1A 1.02151
CCNL1 cyclin L1 1.02114
FOSL2 FOS-like antigen 2 1.02077
SUMF1 sulfatase modifying factor 1 1.01814
ATF3 activating transcription factor 3 1.01625
NR1D1 nuclear receptor subfamily 1, group D, member 1 1.01437
TRHR thyrotropin-releasing hormone receptor 1.01174