Disease Models, Animal Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

245 genes associated with the Disease Models, Animal phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
ADA adenosine deaminase
ADCY7 adenylate cyclase 7
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADH6 alcohol dehydrogenase 6 (class V)
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB2 adrenoceptor beta 2, surface
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
ARRB2 arrestin, beta 2
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
BCL3 B-cell CLL/lymphoma 3
BDNF brain-derived neurotrophic factor
C9 complement component 9
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CARTPT CART prepropeptide
CAT catalase
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHD7 chromodomain helicase DNA binding protein 7
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CLOCK clock circadian regulator
CMYA5 cardiomyopathy associated 5
CNR1 cannabinoid receptor 1 (brain)
CNTF ciliary neurotrophic factor
CNTFR ciliary neurotrophic factor receptor
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CSNK1E casein kinase 1, epsilon
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAOA D-amino acid oxidase activator
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DIO2 deiodinase, iodothyronine, type II
DLK1 delta-like 1 homolog (Drosophila)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAAH fatty acid amide hydrolase
FBXO11 F-box protein 11
FEV FEV (ETS oncogene family)
FGF10 fibroblast growth factor 10
FGF2 fibroblast growth factor 2 (basic)
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FRAS1 Fraser extracellular matrix complex subunit 1
FREM1 FRAS1 related extracellular matrix 1
FREM2 FRAS1 related extracellular matrix protein 2
FUT2 fucosyltransferase 2 (secretor status included)
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAL galanin/GMAP prepropeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GLRA1 glycine receptor, alpha 1
GLRA2 glycine receptor, alpha 2
GLRB glycine receptor, beta
GPC1 glypican 1
GPHN gephyrin
GREM1 gremlin 1, DAN family BMP antagonist
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIP1 glutamate receptor interacting protein 1
GRM1 glutamate receptor, metabotropic 1
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HCRT hypocretin (orexin) neuropeptide precursor
HFE hemochromatosis
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HP haptoglobin
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
IBSP integrin-binding sialoprotein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IL10 interleukin 10
IL22 interleukin 22
IL4R interleukin 4 receptor
IL6 interleukin 6
INHA inhibin, alpha
INHBA inhibin, beta A
INHBB inhibin, beta B
INHBC inhibin, beta C
INHBE inhibin, beta E
ITGA8 integrin, alpha 8
JUN jun proto-oncogene
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM1A lysine (K)-specific demethylase 1A
KDR kinase insert domain receptor
KLF6 Kruppel-like factor 6
KRAS Kirsten rat sarcoma viral oncogene homolog
LASP1 LIM and SH3 protein 1
LEP leptin
LTA4H leukotriene A4 hydrolase
LTBP3 latent transforming growth factor beta binding protein 3
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MPDZ multiple PDZ domain protein
MSX1 msh homeobox 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYH9 myosin, heavy chain 9, non-muscle
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NOD2 nucleotide-binding oligomerization domain containing 2
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY5R neuropeptide Y receptor Y5
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTF3 neurotrophin 3
NTF4 neurotrophin 4
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NTSR1 neurotensin receptor 1 (high affinity)
NTSR2 neurotensin receptor 2
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
OXT oxytocin/neurophysin I prepropeptide
PARL presenilin associated, rhomboid-like
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDYN prodynorphin
PEMT phosphatidylethanolamine N-methyltransferase
PENK proenkephalin
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PNOC prepronociceptin
POMC proopiomelanocortin
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRICKLE1 prickle homolog 1 (Drosophila)
PRKCE protein kinase C, epsilon
PTEN phosphatase and tensin homolog
PTPRA protein tyrosine phosphatase, receptor type, A
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RARA retinoic acid receptor, alpha
RORA RAR-related orphan receptor A
RORB RAR-related orphan receptor B
RSPO3 R-spondin 3
SCN1A sodium channel, voltage gated, type I alpha subunit
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7
SMAD4 SMAD family member 4
SNTA1 syntrophin, alpha 1
SOX4 SRY (sex determining region Y)-box 4
STRN striatin, calmodulin binding protein
T T, brachyury homolog (mouse)
TAC1 tachykinin, precursor 1
TGFA transforming growth factor, alpha
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGM1 transglutaminase 1
TH tyrosine hydroxylase
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TP73 tumor protein p73
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TREM2 triggering receptor expressed on myeloid cells 2
TSHZ2 teashirt zinc finger homeobox 2
TSHZ3 teashirt zinc finger homeobox 3
VASH1 vasohibin 1
VEGFA vascular endothelial growth factor A
ZC3H11B zinc finger CCCH-type containing 11B pseudogene