Diarrhea Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea. (Human Disease Ontology, DOID_13250)
Similar Terms
Downloads & Tools

Genes

76 genes associated with the Diarrhea phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
APOE apolipoprotein E
BRAF B-Raf proto-oncogene, serine/threonine kinase
C8ORF34 chromosome 8 open reading frame 34
CCND1 cyclin D1
CD14 CD14 molecule
CDC42 cell division cycle 42
CEACAM22P carcinoembryonic antigen-related cell adhesion molecule 22, pseudogene
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DPYD dihydropyrimidine dehydrogenase
EGFR epidermal growth factor receptor
ERCC2 excision repair cross-complementation group 2
FAAH fatty acid amide hydrolase
FABP6 fatty acid binding protein 6, ileal
FGF19 fibroblast growth factor 19
FGFR4 fibroblast growth factor receptor 4
GPBAR1 G protein-coupled bile acid receptor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HRAS Harvey rat sarcoma viral oncogene homolog
IL10 interleukin 10
IL13 interleukin 13
IL2RA interleukin 2 receptor, alpha
KLB klotho beta
KRAS Kirsten rat sarcoma viral oncogene homolog
LEP leptin
LPP LIM domain containing preferred translocation partner in lipoma
LTF lactotransferrin
MEFV Mediterranean fever
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MVK mevalonate kinase
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NXPH1 neurexophilin 1
PDZRN3 PDZ domain containing ring finger 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
RETN resistin
RPL9 ribosomal protein L9
SCN5A sodium channel, voltage gated, type V alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC51A solute carrier family 51, alpha subunit
SLC51B solute carrier family 51, beta subunit
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO1B1 solute carrier organic anion transporter family, member 1B1
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TPH1 tryptophan hydroxylase 1
TYMS thymidylate synthetase
UGT1A UDP glucuronosyltransferase 1 family, polypeptide A complex locus
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3