Diabetes Mellitus Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

389 genes associated with the Diabetes Mellitus phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACACB acetyl-CoA carboxylase beta
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACE angiotensin I converting enzyme
ACSM2B acyl-CoA synthetase medium-chain family member 2B
ACTA1 actin, alpha 1, skeletal muscle
ACY3 aminoacylase 3
ADAM17 ADAM metallopeptidase domain 17
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADD1 adducin 1 (alpha)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA2A adrenoceptor alpha 2A
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AGMAT agmatine ureohydrolase (agmatinase)
AGRP agouti related neuropeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
ALPK1 alpha-kinase 1
ALPL alkaline phosphatase, liver/bone/kidney
ALX4 ALX homeobox 4
AMPD1 adenosine monophosphate deaminase 1
ANK1 ankyrin 1, erythrocytic
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
APLN apelin
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
AS3MT arsenite methyltransferase
ATF6 activating transcription factor 6
ATM ATM serine/threonine kinase
ATP11A ATPase, class VI, type 11A
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BCDIN3D BCDIN3 domain containing
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAPN10 calpain 10
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CAT catalase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC123 cell division cycle 123
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CELA2B chymotrypsin-like elastase family, member 2B
CETP cholesteryl ester transfer protein, plasma
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CISD2 CDGSH iron sulfur domain 2
CLEC16A C-type lectin domain family 16, member A
CLPS colipase, pancreatic
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPT1B carnitine palmitoyltransferase 1B (muscle)
CPT2 carnitine palmitoyltransferase 2
CREB1 cAMP responsive element binding protein 1
CRP C-reactive protein, pentraxin-related
CSNK1D casein kinase 1, delta
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNBL1 catenin, beta like 1
CTRB1 chymotrypsinogen B1
CTRB2 chymotrypsinogen B2
CYBA cytochrome b-245, alpha polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCTN5 dynactin 5 (p25)
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
EDN1 endothelin 1
EDNRA endothelin receptor type A
ELOVL2 ELOVL fatty acid elongase 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
ETFDH electron-transferring-flavoprotein dehydrogenase
ETV5 ets variant 5
EXT2 exostosin glycosyltransferase 2
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FABP1 fatty acid binding protein 1, liver
FADS1 fatty acid desaturase 1
FAIM2 Fas apoptotic inhibitory molecule 2
FAM78B family with sequence similarity 78, member B
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGB fibrinogen beta chain
FGFR2 fibroblast growth factor receptor 2
FN3K fructosamine 3 kinase
FOXC2 forkhead box C2
FOXO1 forkhead box O1
FRA1H fragile site, 5-azacytidine type, common, fra(1)(q42)
FTO fat mass and obesity associated
FUT2 fucosyltransferase 2 (secretor status included)
G6PC2 glucose-6-phosphatase, catalytic, 2
GALT galactose-1-phosphate uridylyltransferase
GCG glucagon
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GLS2 glutaminase 2 (liver, mitochondrial)
GNAS GNAS complex locus
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
GNPDA2 glucosamine-6-phosphate deaminase 2
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP6 glycoprotein VI (platelet)
GPX1 glutathione peroxidase 1
GRK4 G protein-coupled receptor kinase 4
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GYS1 glycogen synthase 1 (muscle)
HFE hemochromatosis
HHEX hematopoietically expressed homeobox
HK1 hexokinase 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HP haptoglobin
HPS5 Hermansky-Pudlak syndrome 5
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IAPP islet amyloid polypeptide
IDE insulin-degrading enzyme
IFI30 interferon, gamma-inducible protein 30
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2R insulin-like growth factor 2 receptor
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL15 interleukin 15
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL23R interleukin 23 receptor
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL6 interleukin 6
IL6R interleukin 6 receptor
INS insulin
INSIG2 insulin induced gene 2
IRF5 interferon regulatory factor 5
IRGM immunity-related GTPase family, M
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITLN1 intelectin 1 (galactofuranose binding)
ITLN2 intelectin 2
IVD isovaleryl-CoA dehydrogenase
JAK1 Janus kinase 1
JAZF1 JAZF zinc finger 1
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCTD15 potassium channel tetramerization domain containing 15
KLF11 Kruppel-like factor 11
KLKB1 kallikrein B, plasma (Fletcher factor) 1
LACTB lactamase, beta
LCT lactase
LEP leptin
LEPR leptin receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIPC lipase, hepatic
LIPG lipase, endothelial
LOX lysyl oxidase
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LTA lymphotoxin alpha
LYPLAL1 lysophospholipase-like 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MC4R melanocortin 4 receptor
MEF2A myocyte enhancer factor 2A
MEF2D myocyte enhancer factor 2D
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MRAS muscle RAS oncogene homolog
MSRA methionine sulfoxide reductase A
MT-CYB cytochrome b
MT-ND4 NADH dehydrogenase, subunit 4 (complex I)
MT-TL1 tRNA
MT-TL2 tRNA
MTAP methylthioadenosine phosphorylase
MTCH2 mitochondrial carrier 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTMR9 myotubularin related protein 9
MTNR1B melatonin receptor 1B
MTTP microsomal triglyceride transfer protein
MYH9 myosin, heavy chain 9, non-muscle
NAMPT nicotinamide phosphoribosyltransferase
NAP1L5 nucleosome assembly protein 1-like 5
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCOA6 nuclear receptor coactivator 6
NCR3 natural cytotoxicity triggering receptor 3
ND1
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
NEGR1 neuronal growth regulator 1
NEUROD1 neuronal differentiation 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NLRP1 NLR family, pyrin domain containing 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NOX4 NADPH oxidase 4
NPC1 Niemann-Pick disease, type C1
NPPA natriuretic peptide A
NPY neuropeptide Y
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT5E 5'-nucleotidase, ecto (CD73)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OR10R3P olfactory receptor, family 10, subfamily R, member 3 pseudogene
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PALB2 partner and localizer of BRCA2
PAX4 paired box 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFD platelet derived growth factor D
PDX1 pancreatic and duodenal homeobox 1
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PFKP phosphofructokinase, platelet
PHGDH phosphoglycerate dehydrogenase
PKD2L1 polycystic kidney disease 2-like 1
PKLR pyruvate kinase, liver and RBC
PLA2G10 phospholipase A2, group X
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAGL1 pleiomorphic adenoma gene-like 1
PNPLA3 patatin-like phospholipase domain containing 3
POMC proopiomelanocortin
PON1 paraoxonase 1
POR P450 (cytochrome) oxidoreductase
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PROCR protein C receptor, endothelial
PRODH proline dehydrogenase (oxidase) 1
PRSS1 protease, serine, 1 (trypsin 1)
PTER phosphotriesterase related
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RETN resistin
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG3 secretogranin III
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC16B SEC16 homolog B (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2B1 SH2B adaptor protein 1
SIAE sialic acid acetylesterase
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC16A9 solute carrier family 16, member 9
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SORBS1 sorbin and SH3 domain containing 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTA1 spectrin, alpha, erythrocytic 1
SREBF1 sterol regulatory element binding transcription factor 1
STEAP4 STEAP family member 4
STK11 serine/threonine kinase 11
TBXA2R thromboxane A2 receptor
TCF20 transcription factor 20 (AR1)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERC telomerase RNA component
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB1 transforming growth factor, beta 1
TH tyrosine hydroxylase
THADA thyroid adenoma associated
THBD thrombomodulin
THBS1 thrombospondin 1
THEM4 thioesterase superfamily member 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR4 toll-like receptor 4
TMEM114 transmembrane protein 114
TMEM18 transmembrane protein 18
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53 tumor protein p53
TPH2 tryptophan hydroxylase 2
TREH trehalase (brush-border membrane glycoprotein)
TRL-TAG1-1 transfer RNA-Leu (TAG) 1-1
TSPAN1 tetraspanin 1
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
TYMP thymidine phosphorylase
UBL5 ubiquitin-like 5
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UMODL1 uromodulin-like 1
USF1 upstream transcription factor 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIMP VCP-interacting membrane selenoprotein
VWF von Willebrand factor
WFS1 Wolfram syndrome 1 (wolframin)
WNK4 WNK lysine deficient protein kinase 4