Depressive Disorder Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A condition characterized by pervasive dysphoric mood, loss of interests, and inability to experience pleasure. (Human Phenotype Ontology, HP_0000716)
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Genes

183 genes associated with the Depressive Disorder phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABLIM1 actin binding LIM protein 1
ACE angiotensin I converting enzyme
ACSL4 acyl-CoA synthetase long-chain family member 4
ADCY9 adenylate cyclase 9
ADRA2A adrenoceptor alpha 2A
AGO1 argonaute RISC catalytic component 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALK anaplastic lymphoma receptor tyrosine kinase
ALKBH3 alkB, alkylation repair homolog 3 (E. coli)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOA4 apolipoprotein A-IV
APOE apolipoprotein E
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASMT acetylserotonin O-methyltransferase
AVPR1B arginine vasopressin receptor 1B
BDNF brain-derived neurotrophic factor
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CAT catalase
CCK cholecystokinin
CDH13 cadherin 13
CDH17 cadherin 17, LI cadherin (liver-intestine)
CHAT choline O-acetyltransferase
CHRM2 cholinergic receptor, muscarinic 2
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLOCK clock circadian regulator
CMTM8 CKLF-like MARVEL transmembrane domain containing 8
CNOT3 CCR4-NOT transcription complex, subunit 3
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CNTF ciliary neurotrophic factor
COMT catechol-O-methyltransferase
CPOX coproporphyrinogen oxidase
CREB1 cAMP responsive element binding protein 1
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CSMD2 CUB and Sushi multiple domains 2
CSNK1E casein kinase 1, epsilon
CTSD cathepsin D
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAOA D-amino acid oxidase activator
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DBP D site of albumin promoter (albumin D-box) binding protein
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DGCR8 DGCR8 microprocessor complex subunit
DGKH diacylglycerol kinase, eta
DIO1 deiodinase, iodothyronine, type I
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DTNBP1 dystrobrevin binding protein 1
EGFR epidermal growth factor receptor
EPHB1 EPH receptor B1
ESR1 estrogen receptor 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM135A family with sequence similarity 135, member A
FASN fatty acid synthase
FIGN fidgetin
FKBP5 FK506 binding protein 5
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GBA glucosidase, beta, acid
GMIP GEM interacting protein
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPR50 G protein-coupled receptor 50
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRID1 glutamate receptor, ionotropic, delta 1
GRIK4 glutamate receptor, ionotropic, kainate 4
GRM1 glutamate receptor, metabotropic 1
GRM3 glutamate receptor, metabotropic 3
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HDAC5 histone deacetylase 5
HMGB4 high mobility group box 4
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTRA1 HtrA serine peptidase 1
HTT huntingtin
IDO1 indoleamine 2,3-dioxygenase 1
IL10 interleukin 10
IL11 interleukin 11
IL1B interleukin 1, beta
IL4 interleukin 4
IL6 interleukin 6
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KCNK2 potassium channel, two pore domain subfamily K, member 2
KDR kinase insert domain receptor
KLK8 kallikrein-related peptidase 8
KPNA3 karyopherin alpha 3 (importin alpha 4)
LEP leptin
LGSN lengsin, lens protein with glutamine synthetase domain
LTA4H leukotriene A4 hydrolase
M6PR mannose-6-phosphate receptor (cation dependent)
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED12 mediator complex subunit 12
MLH1 mutL homolog 1
MOB1B MOB kinase activator 1B
MSH2 mutS homolog 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYO3A myosin IIIA
NARF nuclear prelamin A recognition factor
NFIL3 nuclear factor, interleukin 3 regulated
NGFR nerve growth factor receptor
NOS1 nitric oxide synthase 1 (neuronal)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPAS2 neuronal PAS domain protein 2
NPAS3 neuronal PAS domain protein 3
NPY neuropeptide Y
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUP214 nucleoporin 214kDa
OPRM1 opioid receptor, mu 1
OR4B1 olfactory receptor, family 4, subfamily B, member 1
OXTR oxytocin receptor
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PCLO piccolo presynaptic cytomatrix protein
PDE11A phosphodiesterase 11A
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDE4B phosphodiesterase 4B, cAMP-specific
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PDE9A phosphodiesterase 9A
PER1 period circadian clock 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLXNA2 plexin A2
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
PON1 paraoxonase 1
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAI1 retinoic acid induced 1
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RORA RAR-related orphan receptor A
S100A10 S100 calcium binding protein A10
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
TAAR6 trace amine associated receptor 6
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TH tyrosine hydroxylase
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TNF tumor necrosis factor
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TTC1 tetratricopeptide repeat domain 1
UST uronyl-2-sulfotransferase
VEGFA vascular endothelial growth factor A
WWC1 WW and C2 domain containing 1