Depressive Disorder, Major Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D003865
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Genes

177 genes/proteins associated with the disease Depressive Disorder, Major from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
RELN reelin 2.88009
XDH xanthine dehydrogenase 2.88009
CAT catalase 2.88009
SOD2 superoxide dismutase 2, mitochondrial 2.88009
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.88009
MPO myeloperoxidase 2.88009
CRHR1 corticotropin releasing hormone receptor 1 2.88009
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.88009
TAC1 tachykinin, precursor 1 2.88009
TPH2 tryptophan hydroxylase 2 2.88009
FKBP5 FK506 binding protein 5 2.88009
MDD1 Major depressive disorder 2.88009
IL2 interleukin 2 2.88009
MDD2 Major depressive disorder 2 2.88009
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.41418
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.31557
PRL prolactin 2.28712
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.28007
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.24945
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.24705
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.24124
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.22823
BDNF brain-derived neurotrophic factor 2.15659
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.10508
FOS FBJ murine osteosarcoma viral oncogene homolog 2.10352
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.01336
MAPK1 mitogen-activated protein kinase 1 1.96224
TNF tumor necrosis factor 1.93368
SOD1 superoxide dismutase 1, soluble 1.9296
MAPK3 mitogen-activated protein kinase 3 1.92626
DRD2 dopamine receptor D2 1.91001
CREB1 cAMP responsive element binding protein 1 1.88376
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.85116
BCL2 B-cell CLL/lymphoma 2 1.82656
CRH corticotropin releasing hormone 1.81375
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.79063
INS insulin 1.74421
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.73231
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.73028
TH tyrosine hydroxylase 1.72905
BAX BCL2-associated X protein 1.71728
EGR1 early growth response 1 1.71728
NPY neuropeptide Y 1.71606
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.71338
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.71235
VEGFA vascular endothelial growth factor A 1.70224
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.70119
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.64123
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.61295
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.6043
ARC activity-regulated cytoskeleton-associated protein 1.60035
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.59943
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.58279
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.57688
LHB luteinizing hormone beta polypeptide 1.55231
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.55231
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.54548
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.54111
TAGLN transgelin 1.50725
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.49787
SREBF1 sterol regulatory element binding transcription factor 1 1.49071
GSK3B glycogen synthase kinase 3 beta 1.47556
C10ORF10 chromosome 10 open reading frame 10 1.46251
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.4583
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.45643
IL6 interleukin 6 1.44982
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.44273
HOMER1 homer scaffolding protein 1 1.43428
DRD3 dopamine receptor D3 1.42266
DRD1 dopamine receptor D1 1.42156
MAOA monoamine oxidase A 1.41965
NUPR1 nuclear protein, transcriptional regulator, 1 1.41174
JUN jun proto-oncogene 1.40953
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.40176
MBP myelin basic protein 1.40176
FAS Fas cell surface death receptor 1.38835
DUSP1 dual specificity phosphatase 1 1.381
GAL galanin/GMAP prepropeptide 1.37761
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.35934
IL1B interleukin 1, beta 1.35618
PENK proenkephalin 1.35386
FNDC4 fibronectin type III domain containing 4 1.35041
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.35012
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.34343
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.33701
GRIK2 glutamate receptor, ionotropic, kainate 2 1.33672
EGFR epidermal growth factor receptor 1.33672
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.32935
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.30941
NOS2 nitric oxide synthase 2, inducible 1.30329
POMC proopiomelanocortin 1.29905
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.29317
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.29072
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.28272
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.27502
IGF1 insulin-like growth factor 1 (somatomedin C) 1.27009
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.26236
GSTP1 glutathione S-transferase pi 1 1.26236
CTSK cathepsin K 1.26205
GFAP glial fibrillary acidic protein 1.25183
GSK3A glycogen synthase kinase 3 alpha 1.24655
REN renin 1.24496
COL1A1 collagen, type I, alpha 1 1.23424
COMT catechol-O-methyltransferase 1.23137
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.23074
INHBE inhibin, beta E 1.22112
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.22016
FABP1 fatty acid binding protein 1, liver 1.21759
FSHB follicle stimulating hormone, beta polypeptide 1.21468
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.21468
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.19933
SNAP25 synaptosomal-associated protein, 25kDa 1.19737
TGFB1 transforming growth factor, beta 1 1.19279
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.18521
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.18521
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.18126
FOXO1 forkhead box O1 1.17893
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.17101
HRH1 histamine receptor H1 1.17101
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.16335
SREBF2 sterol regulatory element binding transcription factor 2 1.15865
OXT oxytocin/neurophysin I prepropeptide 1.15324
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.14885
CCND1 cyclin D1 1.14644
EGR3 early growth response 3 1.14438
MMP2 matrix metallopeptidase 2 1.14336
NFE2L2 nuclear factor, erythroid 2-like 2 1.14234
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.14098
AVP arginine vasopressin 1.13862
ADORA1 adenosine A1 receptor 1.13621
EGR2 early growth response 2 1.13621
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.13518
PARP1 poly (ADP-ribose) polymerase 1 1.13415
RND3 Rho family GTPase 3 1.13381
PER1 period circadian clock 1 1.13075
VCAM1 vascular cell adhesion molecule 1 1.12872
MAPK8 mitogen-activated protein kinase 8 1.12426
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.12391
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.12219
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.11775
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.1136
MAPK14 mitogen-activated protein kinase 14 1.11151
LDLR low density lipoprotein receptor 1.11081
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.10803
PPARG peroxisome proliferator-activated receptor gamma 1.10769
CCK cholecystokinin 1.09892
MAP2K1 mitogen-activated protein kinase kinase 1 1.09611
DUSP6 dual specificity phosphatase 6 1.09401
GH1 growth hormone 1 1.08762
INHA inhibin, alpha 1.08513
CDK5 cyclin-dependent kinase 5 1.08478
BCL2L1 BCL2-like 1 1.08407
PLAT plasminogen activator, tissue 1.08196
IGF2 insulin-like growth factor 2 1.08126
S100B S100 calcium binding protein B 1.07804
GJA1 gap junction protein, alpha 1, 43kDa 1.07447
IL10 interleukin 10 1.07305
GAP43 growth associated protein 43 1.07234
FGF2 fibroblast growth factor 2 (basic) 1.06987
LEP leptin 1.06808
SPP1 secreted phosphoprotein 1 1.06225
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.05757
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.0561
ENO1 enolase 1, (alpha) 1.05163
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.04501
HMGB2 high mobility group box 2 1.04501
POR P450 (cytochrome) oxidoreductase 1.03345
MSMO1 methylsterol monooxygenase 1 1.03235
CXCL10 chemokine (C-X-C motif) ligand 10 1.03197
IGF1R insulin-like growth factor 1 receptor 1.03122
DDIT4 DNA-damage-inducible transcript 4 1.03122
MMP9 matrix metallopeptidase 9 1.02634
GRIK5 glutamate receptor, ionotropic, kainate 5 1.02373
ALB albumin 1.02262
PRLR prolactin receptor 1.01739
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.01249
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.01137