Dengue Hemorrhagic Fever Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever. (Human Disease Ontology, DOID_12206)
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Genes

103 genes associated with the Dengue Hemorrhagic Fever phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADAR adenosine deaminase, RNA-specific
AQR aquarius intron-binding spliceosomal factor
AR androgen receptor
CD209 CD209 molecule
CD81 CD81 molecule
CFH complement factor H
CKM creatine kinase, muscle
CLEC4C C-type lectin domain family 4, member C
CREBBP CREB binding protein
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DRD2 dopamine receptor D2
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
F13B coagulation factor XIII, B polypeptide
FADD Fas (TNFRSF6)-associated via death domain
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
GC group-specific component (vitamin D binding protein)
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
ICAM1 intercellular adhesion molecule 1
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA13 interferon, alpha 13
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA8 interferon, alpha 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNE interferon, epsilon
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFNK interferon, kappa
IFNW1 interferon, omega 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL6 interleukin 6
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
LPL lipoprotein lipase
MAPK14 mitogen-activated protein kinase 14
MBL2 mannose-binding lectin (protein C) 2, soluble
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MICB MHC class I polypeptide-related sequence B
MX1 MX dynamin-like GTPase 1
MYD88 myeloid differentiation primary response 88
NFASC neurofascin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NRP1 neuropilin 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF31 ring finger protein 31
SAP30L SAP30-like
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SPTBN1 spectrin, beta, non-erythrocytic 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBK1 TANK-binding kinase 1
TGFB1 transforming growth factor, beta 1
TICAM1 toll-like receptor adaptor molecule 1
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR3 toll-like receptor 3
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAM1 translocation associated membrane protein 1
TYK2 tyrosine kinase 2
TYR tyrosinase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor