Death, Sudden, Cardiac Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

119 genes associated with the Death, Sudden, Cardiac phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTC1 actin, alpha, cardiac muscle 1
ACYP2 acylphosphatase 2, muscle type
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AGXT2 alanine--glyoxylate aminotransferase 2
ANK2 ankyrin 2, neuronal
ANXA5 annexin A5
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APOB apolipoprotein B
APOE apolipoprotein E
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BDKRB2 bradykinin receptor B2
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CASQ2 calsequestrin 2 (cardiac muscle)
CPB2 carboxypeptidase B2 (plasma)
CSMD2 CUB and Sushi multiple domains 2
CTNNA3 catenin (cadherin-associated protein), alpha 3
CXADR coxsackie virus and adenovirus receptor
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEGS2 delta(4)-desaturase, sphingolipid 2
DSC2 desmocollin 2
DSG2 desmoglein 2
DSP desmoplakin
ESR1 estrogen receptor 1
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FBN1 fibrillin 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
GINS3 GINS complex subunit 3 (Psf3 homolog)
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP6 glycoprotein VI (platelet)
GPC5 glypican 5
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPR37L1 G protein-coupled receptor 37 like 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HRC histidine rich calcium binding protein
IL18 interleukin 18
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUP junction plakoglobin
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCNQ1OT1 KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)
KCTD1 potassium channel tetramerization domain containing 1
KNG1 kininogen 1
LDLR low density lipoprotein receptor
LIG3 ligase III, DNA, ATP-dependent
LIN9 lin-9 DREAM MuvB core complex component
LIPC lipase, hepatic
LITAF lipopolysaccharide-induced TNF factor
LPCAT1 lysophosphatidylcholine acyltransferase 1
MBL2 mannose-binding lectin (protein C) 2, soluble
MLYCD malonyl-CoA decarboxylase
MMP3 matrix metallopeptidase 3
MYBPC3 myosin binding protein C, cardiac
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
NDRG4 NDRG family member 4
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NRG1 neuregulin 1
PKP2 plakophilin 2
PLN phospholamban
PON1 paraoxonase 1
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
REN renin
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RNF207 ring finger protein 207
RYR2 ryanodine receptor 2 (cardiac)
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC25A45 solute carrier family 25, member 45
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLN sarcolipin
SREBF2 sterol regulatory element binding transcription factor 2
TH tyrosine hydroxylase
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TPM1 tropomyosin 1 (alpha)
TTN titin
USF1 upstream transcription factor 1
VWF von Willebrand factor
ZNF365 zinc finger protein 365
ZNF385B zinc finger protein 385B
ZNF592 zinc finger protein 592